Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation

Kretz, Alexandra; Happold, Caroline; Marticke, Julia; Isenmann, Stefan

doi:10.1016/j.mcn.2005.04.009

Cited by 161 publications

(116 citation statements)

References 54 publications

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“…1). Inhibition of Jak2/Stat3 abolished Epo-induced growth verifying the pathway is involved in conferring regeneration-enhancing Epo functions in the retina (129).…”

Section: Neuroprotection By Epo In Vitromentioning

confidence: 88%

Epo and Non-hematopoietic Cells: What Do We Know?

Ogunshola

Bogdanova

2013

Methods in Molecular Biology

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“…1). Inhibition of Jak2/Stat3 abolished Epo-induced growth verifying the pathway is involved in conferring regeneration-enhancing Epo functions in the retina (129).…”

Section: Neuroprotection By Epo In Vitromentioning

confidence: 88%

Epo and Non-hematopoietic Cells: What Do We Know?

Ogunshola

Bogdanova

2013

Methods in Molecular Biology

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“…80 The JAK2-STAT3 and PI3K-AKT pathways activated by EPO may also underlie the EPO-mediated neuronal regeneration. 81 Thus, multiple signaling pathways may regulate the EPO-induced angiogenesis and neurogenesis that promote neurorestorative effects after stroke.…”

Section: Erythropoietinmentioning

confidence: 99%

Neurorestorative treatment of stroke: Cell and pharmacological approaches

Chen

Chopp

2006

NeuroRX

153

114

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Summary:There is a compelling need to develop cell and pharmacological therapeutic approaches to be administered beyond the hyperacute phase of stroke. These therapies capitalize on the capacity of the brain for neuroregeneration and neuroplasticity and are designed to reduce neurological deficits after stroke. This review provides an update of bone marrowderived mesenchymal stem cells (MSCs) and select pharmacological agents in clinical use for other indications that promote the recovery process in the subacute and chronic phases after stroke. Among these agents are 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins), erythropoietin (EPO), and phosphodiesterase type 5 (PDE-5) inhibitors and nitric oxide (NO) donors. Both the MSCs and the pharmacologic agents potentiate brain plasticity and neurobehavioral recovery after stroke.

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“…However, the mechanism of the axonal regeneration effect of EPO on retinal neurons has not been fully clarified. A previous study has shown that EPO promotes the regeneration of adult CNS neurons via activation of the JAK2/STAT3 and PI3K/AKT pathways, and that EPO-facilitated neuritogenesis is paralleled by the upregulation of Bcl-X(L) (35). However, the induced expression of Bcl-X(L) alone cannot completely neutralize the inhibition of axonal growth (36).…”

Section: Discussionmentioning

confidence: 99%

The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate

Huang

Wang

Shen

et al. 2012

Molecular Medicine Reports

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Abstract. The aim of this study was to investigate the effects of erythropoietin (EPO) on RhoA/Rho-associated kinase (ROCK) expression in rat retinal explants cultured with glutamate. After the retinal explants were cultured in serumfree R16 nutrient medium for 24 h, the retinal explants were divided into control (R16 nutrient medium), glutamate (R16 nutrient medium containing 5 mM/l glutamate) and glutamate + EPO (R16 nutrient medium containing 5 mM/l glutamate and 6.0 U/ml EPO) groups, and culturing was continued for another 72 h. The mRNA and protein expression of total RhoA, ROCK1 and ROCK2 in the retinal explants was examined by RT-PCR and western blotting, and active RhoA in the retinal explants was detected via GST-RBD binding and immunoblotting with an antibody specific to active RhoA. The total RhoA mRNA and protein expression did not differ substantially between the control, the glutamate and the glutamate + EPO groups. The glutamate increased the active RhoA, ROCK1 and ROCK2 expression in cultured retinal explants (P<0.05), whereas the expression of active RhoA, ROCK1 and ROCK2 in the glutamate + EPO group was significantly lower than that in the simple glutamate group (P<0.05) and similar to that in the control group. In conclusion, EPO downregulates active RhoA, ROCK1 and ROCK2 expression in retinal explants cultured with glutamate.

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Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation

Cited by 161 publications

References 54 publications

Epo and Non-hematopoietic Cells: What Do We Know?

Epo and Non-hematopoietic Cells: What Do We Know?

Neurorestorative treatment of stroke: Cell and pharmacological approaches

The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate

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