Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation

Dara, Tahereh; Vatanara, Alireza; Meybodi, Mohsen Nabi; Vakilinezhad, Molood Alsadat; Malvajerd, Soroor Sadegh; Vakhshiteh, Faezeh; Shamsian, Azam; Sharifzadeh, Mohammad; Kaghazian, Hooman; Mosaddegh, Mohammad Hossein

doi:10.1016/j.colsurfb.2019.01.027

Cited by 31 publications

(12 citation statements)

References 47 publications

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“…As said before, decreasing the amount of lipid incorporated into the formulation frequently helps to reduce particle size, but has a negative effect on the entrapment efficiency (Kurakula et al, 2016;Talluri et al, 2017;Ahmad et al, 2019). Simultaneous optimization of both responses as a function of the formulation components and/or process operational variables allows to find the optimum compromise solution as well as other possible approaches, such as increasing the energy (frequency, speed) during the synthesis to decrease the particle size without sacrificing entrapment efficiency (Nooli et al, 2017;Dara et al, 2019;Khatri et al, 2019;Patel et al, 2019a), or decreasing the surfactant/lipid ratio (Bhalekar et al, 2017;Pandya et al, 2018;Ahmad et al, 2019).…”

Section: The Tiny Big Universe Of Lipid Nanoparticlesmentioning

confidence: 97%

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Montoto

Muraca

Ruiz

2020

Front. Mol. Biosci.

342

148

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Section: The Tiny Big Universe Of Lipid Nanoparticlesmentioning

confidence: 97%

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Montoto

Muraca

Ruiz

2020

Front. Mol. Biosci.

342

148

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“…It is also a top priority to address these problems, and novel methods have been developed to investigate the flavonoids' utility in animal models through involving new methods and through optimizing its biological applications, like hepatoprotective effectiveness, via the development of formulations [8,9]. One exciting strategy for addressing these issues is the development of NPs as regulated drug delivery systems for increasing the oral bioavailability of hydrophobic and lipophilic drugs such as KFP [10,11]. This may be done in many ways such as specialized uptake mechanisms, long-term release, longer half-lives (t 1/2 ), reduced toxicity, and improved NPs' capacity to traverse physiological boundaries inside the body of an animal.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Kaempferol Loaded Nanoparticles against Experimentally Induced Hepatocellular Carcinoma: In Vitro and In Vivo Studies

et al. 2021

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The present study was designed to prepare Kaempferol loaded nanoparticles (KFP-Np) and evaluate hepatoprotective and antioxidant effects in hepatocellular carcinoma models. KFP was encapsulated with hydroxypropyl methylcellulose acetate succinate (HPMC-AS) and Kollicoat MAE 30 DP polymers to prepare nanoparticles (Nps) by quasi-emulsion solvent diffusion technique (QESD). The prepared Nps were evaluated for different pharmaceutical characterization to select the optimum composition for the in vivo assessment. An animal model of cadmium chloride (CdCl2)-induced hepatocellular carcinoma in Male Sprague Dawley rats was used in vivo to test the antioxidant and hepatoprotective capacity of free and encapsulated KFP. The prepared Npsshowed nanometric size, low PDI, high drug load as well as encapsulation with a better drug release profile. There was a significant decrease in the increased serum levels of alanine transaminase (ALT), total bilirubin (TBiL), and aspartate transaminase (AST), and the lipid peroxidation’s (MDA) level was attenuated, and levels of markers of the cell antioxidant defence system were restored including Glutathione S-transferase (GST), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) via oral pre-treatment with KFP-Np (50 mg/kg b.w. (body weight), 6 weeks). KFP-Np significantly declines an mRNA expression of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) as well as decreased nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein expression. It also upregulated the mRNA expression and protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). While comparing the protective effects of KFP encapsulated in Kollicoat MAE 30 DP and HPMC-AS, Nps was found to be betterthan free KFP. Insummary, result indicate that encapsulation of KFP in NPs provides a potential platform for oxidative stress induce liver injury.

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“…This way, Dara et al created EPO-loaded SLN to alleviate the restrictions mentioned above. 151 In vivo studies showed that EPO-SLN could protect the animals’ brains from damage caused by an intra-hippocampal injection, with spatial recognition memory considerably recovered compared to rats treated with free EPO. Another synthetic drug, nicotinamide, a histone deacetylase blocker demonstrated in preclinical trials to be beneficial in stopping AD, has poor absorption.…”

Section: Nanoformulations In Combating Neurodegeneration: Pre-clinical Evidencementioning

confidence: 99%

“…This hydrophilic medication was encapsulated in SLN, who functionalized the nanocarriers using polysorbate 80, phosphatidylserine, or phosphatidic acid. 151 When compared to traditional oral nicotinamide, the phosphatidylserine-SLN was efficient in conveying and distributing nicotinamide to the brain in a sustained manner, supposed to lead to cognition enhancement, protection of more neuronal cells (higher neuronal counts in hippocampus subregions) and decrease of tau hyperphosphorylation in an AD rat model.…”

Section: Nanoformulations In Combating Neurodegeneration: Pre-clinical Evidencementioning

confidence: 99%

Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases

Fakhri¹,

Abdian²,

Zarneshan³

et al. 2022

IJN

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As the worldwide average life expectancy has grown, the prevalence of age-related neurodegenerative diseases (NDDs) has risen dramatically. A progressive loss of neuronal function characterizes NDDs, usually followed by neuronal death. Inflammation, apoptosis, oxidative stress, and protein misfolding are critical dysregulated signaling pathways that mainly orchestrate neuronal damage from a mechanistic point. Furthermore, in afflicted families with genetic anomalies, mutations and multiplications of α-synuclein and amyloid-related genes produce some kinds of NDDs. Overproduction of such proteins, and their excessive aggregation, have been proven in various models of neuronal malfunction and death. In this line, providing multi-target therapies carried by novel delivery systems would pave the road to control NDDs through simultaneous modulation of such dysregulated pathways. Phytochemicals are multi-target therapeutic agents, which employ several mechanisms towards neuroprotection. Besides, the blood–brain barrier (BBB) is a critical issue in managing NDDs since it inhibits the accessibility of drugs to the brain in sufficient concentration. Besides, discovering novel delivery systems is vital to improving the efficacy, bioavailability, and pharmacokinetic of therapeutic agents. Such novel formulations are also employed to improve the drug’s biodistribution, allow for the co-delivery of several medicines, and offer targeted intracellular delivery against NDDs. The present review proposes nanoformulations of phytochemicals and synthetic agents to combat NDDs by modulating neuroinflammation, neuroapoptosis, neuronal oxidative stress pathways and protein misfolding.

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Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation

Cited by 31 publications

References 47 publications

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Formulation and Evaluation of Kaempferol Loaded Nanoparticles against Experimentally Induced Hepatocellular Carcinoma: In Vitro and In Vivo Studies

Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases

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