Abstract:Background Recently, erythropoietin (EPO) was identified as an important regulator of production and cleavage of fibroblast growth factor 23 (FGF23). Since erythroid progenitor cells express high levels of FGF23 and carry the FGF receptor, they are involved in the FGF23 metabolic pathway.
FGF23 is a bone-derived hormone, a key player in phosphate and vitamin D metabolism and regulator of bone mineralization. FGF23 is formed as intact, biologically active protein (iFGF23). Proteolytic cleavage re… Show more
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