Erythropoietin-Induced Optimization of Renal Function After Warm Ischemia

Phillips, Courtney K.; Hruby, Gregory W.; Mirabile, Gabriella; Motamedinia, Piruz; Lehman, Daniel S.; Okhunov, Zhamshid; Singh, Harmanmeet; Schwartz, Marissa; Benson, Mitchell C.; Landman, Jaime

doi:10.1089/end.2008.0183

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…EPO increases the risk of thrombosis, and the dosage used in this study is higher than the doses commonly used in the clinic. Although a single bolus of high‐dose EPO increases the hematocrit only to a minor extent, if at all, EPO should be used with caution, especially in critically ill patients, who are already at an increased risk of vascular thrombosis 18,30 . Recently, new EPO‐like derivatives, such as desialylated EPO (asialo‐EPO) and carbamoylated EPO (CEPO), have been developed.…”

Section: Discussionmentioning

confidence: 99%

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Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury

Sølling

Christensen

Krag³

et al. 2011

Acta Anaesthesiologica Scandinavica

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Section: Discussionmentioning

confidence: 99%

“…Three previous studies have examined the effect of EPO on renal dysfunction in large‐animal models of IRI 16–18 . However, none of these studies focused on the immediate effects of EPO or on its immunomodulatory properties.…”

mentioning

confidence: 99%

Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury

Sølling

Christensen

Krag³

et al. 2011

Acta Anaesthesiologica Scandinavica

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“…7 In recent years, additional tissue/organ protective properties of erythropoietin against ischemia and reperfusion injury have become apparent. 8 The cytoprotective, preconditioning, and antiapoptotic effects of erythropoietin on kidneys have been shown in both experimental [9][10][11][12][13][14][15] and a few human studies. [16][17][18] Available evidence suggests that these pleiotropic effects of erythropoietin are mediated by a tissue protective receptor that is distinct from the receptor responsible for erythropoiesis.…”

mentioning

confidence: 99%

Erythropoietin and Protection of Renal Function in Cardiac Surgery (the EPRICS Trial)

Dardashti

Ederoth²,

Algotsson³

et al. 2014

Anesthesiology

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“…The dog model of the kidney provides only a unipapillate collecting system, but the kidney is more sensitive to warm ischemia and hemorrhage according to other animal studies. 11 As such, the dog model would not be appropriate for our proposed entry into the collecting system.…”

Section: Discussionmentioning

confidence: 99%

Bovine Serum Albumin Glutaraldehyde for Completely Sutureless Laparoscopic Heminephrectomy in a Survival Porcine Model

Louie

Gamboa

Kaplan

et al. 2010

Journal of Endourology

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Introduction: Laparoscopic partial nephrectomy (LPN) has not received widespread clinical application because of its technical challenge. Bovine serum albumin glutaraldehyde (BSAG) is a hemostatic agent that is independent of the clotting cascade. We evaluated the use of BSAG as the sole agent for parenchymal and collecting system closure during LPN in a survival porcine model. Methods: Eighteen pigs underwent hilar clamping and LPN by longitudinal excision of the lateral one-third of the right kidney. The opened collecting system was covered with oxidized cellulose to prevent BSAG seepage into the urinary tract. BSAG was allowed to set for 10 or 5 minutes. Twelve animals underwent survival LPN BSAG only closure; six control pigs were acutely studied using saline. Urinary extravasation was evaluated by injection of furosemide and indigo carmine, and then evaluating the renal surface and bladder catheter drainage for dye. A subjective bleeding score was assigned after hilum unclamping. At 6 weeks, BSAG kidneys were harvested for burst pressure testing and histopathological analysis. Results: All 12 pigs survived for 6 weeks. No pigs had urinary extravasation. Mean percentage of kidney removed by weight was 19%. Mean warm ischemia time was 29 minutes. Five pigs required a second BSAG application to achieve a bleeding score of 0. Mean arterial and collecting system burst pressures were 301.8 and 322.4 mm Hg, respectively. Mean postoperative creatinine increase was 0.07 mg=dL. Conclusion: BSAG for completely sutureless LPN in a survival porcine model was feasible.

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Erythropoietin-Induced Optimization of Renal Function After Warm Ischemia

Abstract: The current study demonstrates that administering Epo before warm ischemia can improve the recovery of renal function after ischemia better than placebo or mannitol.

Cited by 7 publications

References 31 publications

Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury

Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury

Erythropoietin and Protection of Renal Function in Cardiac Surgery (the EPRICS Trial)

Bovine Serum Albumin Glutaraldehyde for Completely Sutureless Laparoscopic Heminephrectomy in a Survival Porcine Model

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