Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus

Garmabi, Behzad; Mohaddes, Reza; Rezvani, Fatemeh; Mohseni, Fahimeh; Khastar, Hossein; Khaksari, Mehdi

doi:10.1016/j.jchemneu.2022.102137

Cited by 2 publications

(1 citation statement)

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“…EPO has also improved cognitive function in mice with behavioral tasks such as the Morris water maze, sociability test, Y-maze, etc. (Sargin et al, 2011;Vittori et al, 2021;Garmabi et al, 2022). The inhibition of EPO suggests that there is a loss of neuroprotective function.…”

Section: Discussionmentioning

confidence: 99%

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

Corley,

McElroy,

Sridharan

et al. 2023

Front. Neurosci.

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IntroductionChemotherapy-induced cognitive impairment colloquially referred to as chemobrain is a poorly understood phenomenon affecting a highly variable proportion of patients with breast cancer. Here we investigate the association between anxiety and despair-like behaviors in mice treated with cyclophosphamide, methotrexate, and fluorouracil (CMF) along with host histological, proteomic, gene expression, and gut microbial responses.MethodsForced swim and sociability tests were used to evaluate depression and despair-like behaviors. The tandem mass tag (TMT) proteomics approach was used to assess changes in the neural protein network of the amygdala and hippocampus. The composition of gut microbiota was assessed through 16S rRNA gene sequencing. Finally, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate changes in intestinal gap junction markers.Results and discussionWe observed that CMF induced social and despair-like behavior in mice 96 hours following treatment. Proteomic analysis identified changes in various proteins related to progressive neurological disease, working memory deficit, primary anxiety disorder, and gene expression revealing increases in NMDA and AMPA receptors in both the hippocampus and the amygdala because of CMF treatment. These changes finally, we observed immediate changes in the microbial population after chemotherapy treatment, with a notable abundance of Muribaculaceae and Romboutsia which may contribute to changes seen in the gut.

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Section: Discussionmentioning

confidence: 99%

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

Corley,

McElroy,

Sridharan

et al. 2023

Front. Neurosci.

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Methamphetamine

Krishnan

2024

Drug Addiction Mechanisms in the Brain

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Methamphetamine (METH) is a highly addictive stimulant that affects the central nervous system. It is a widely abused psychostimulant. Monoaminergic neurotransmitter terminals are affected by METH intake. METH structure is very similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder (ADHD). METH is taken in various modes, such as smoking, swallowing, snorting, injecting powder, etc. Dopamine levels, serotonin levels, and norepinephrine levels are increased due to METH uptake, leading to extremely strong euphoric effects. This dopamine surge causes the brain to repeatedly take the drug and is responsible for addiction. As a short-term effect, METH causes increased wakefulness and physical activity, decreased appetite, faster breathing, rapid and/or irregular heartbeat, increased blood pressure, and body temperature. METH overdose causes hyperthermia and convolution, which can lead to death if not treated. METH also causes irreversible brain damage. Amphetamine psychosis, dementia-like symptoms, increased anti-social behaviour, and increased susceptibility to neurodegenerative diseases are the long-term neurological effects of METH use.

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Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus

Cited by 2 publications

References 51 publications

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

Methamphetamine

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