Erythropoietin exerts direct immunomodulatory effects on the cytokine production by activated human T-lymphocytes

Тодосенко, Н. М.; Shmarov, V.A.; Малащенко, В. В.; Meniailo, M. E.; Melashchenko, Olga Borisovna; Газатова, Н. Д.; Гончаров, А. Г.; Селедцов, В. И.

doi:10.1016/j.intimp.2016.05.006

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…These findings are consistent with a previous study indicating that hemodialysis procedures are, at least in part, responsible for the development of T cell lymphopenia due to the induction of apoptosis (Table 1) [58]. Data from our group and other authors highlighted the immunological effect of erythropoietin (EPO) in counteracting T cell effects: EPO ligation of its receptor on CD4+ T cells has been proven to directly prevent Th17 generation and to induce trans-differentiation of Th17 into IL-17-Foxp3+ CD4+ T cells, downregulating the pro-inflammatory T cell response [59][60][61][62][63][64][65]. Recombinant human erythropoietin (rhEPO) is usually administered at the end of hemodialysis treatment, therefore it represents a further variant to consider in the modulation of the immune system of the single hemodialysis.…”

Section: T Cellsmentioning

confidence: 91%

Immunological Effects of a Single Hemodialysis Treatment

et al. 2020

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Immune disorders, involving both innate and adaptive response, are common in patients with end-stage renal disease under chronic hemodialysis. Endogenous and exogenous factors, such as uremic toxins and the extracorporeal treatment itself, alter the immune balance, leading to chronic inflammation and higher risk of cardiovascular events. Several studies have previously described the immune effects of chronic hemodialysis and the possibility to modulate inflammation through more biocompatible dialyzers and innovative techniques. On the other hand, very limited data are available on the possible immunological effects of a single hemodialysis treatment. In spite of the lacking information about the immunological reactivity related to a single session, there is evidence to indicate that mediators of innate and adaptive response, above all complement cascade and T cells, are implicated in immune system modulation during hemodialysis treatment. Expanding our understanding of these modulations represents a necessary basis to develop pro-tolerogenic strategies in specific conditions, like hemodialysis in septic patients or the last session prior to kidney transplant in candidates for receiving a graft.

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Section: T Cellsmentioning

confidence: 91%

Immunological Effects of a Single Hemodialysis Treatment

et al. 2020

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“…E.g., antioxidant in vivo eff ects of EPO (reduced lipid peroxidation in blood lymphocytes) are shown by Osikov et al [3]. Immunotropic eff ects of EPO are recently studied, due to its immunomodulatory eff ects under clinical and experimental conditions [4][5][6]. Response of lymphocytes and macrophages to EPO seems to be mediated by the EPO receptors on their surface [7].…”

Section: Resultsmentioning

confidence: 99%

In vitro modifying effect of erythropoietin upon thymic lymphocytes: an inhibitor analysis

Parkhomenko¹,

Tomson²,

Galibin³

2018

CTT

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“…In this part of the study, we applied a multi-color flow cytometry protocol established in our laboratory and described in detail in our previous reports. [21][22][23][24] Briefly, our algorithm allowed for identification of human CD4-positive and CD4-negative T cells, with their further subclassification into naïve СD45RA + /СD197 + , central memory СD45RA − /СD197 + , effector memory СD45RA − /СD197 − , and terminally differentiated effector СD45RA + /СD197 − T cells. We showed previously that the overwhelming majority of CD4-negative T cells belonged to a CD8-positive cell population.…”

Section: Effects Of Gm-csf On Phenotype and Cytokine Production Patterns Of Various T Cell Subpopulationsmentioning

confidence: 99%

Directs effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on adaptive immunogenesis

Селедцов

Малащенко

Газатова

et al. 2019

Human Vaccines & Immunotherapeutics

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Background: We studied direct effects of human granulocyte-macrophage colony stimulating factor (GM-CSF) on phenotypical characteristics and cytokine-production of non-activated and activated human monocytes/macrophages (Mc/Mphs) and T cells. Methods: Purified Mc/Mphs were activated by bacterial lipopolysaccharide (LPS, 1 μg/ml) for 24 h, while T cells were activated by particles conjugated and antibodies (Abs) against human CD2, CD3, and CD28 for 48 h. Results: GM-CSF treatment (0.01-10 ng/ml) was shown to reduce percentages of CD197 (CCR7)-positive cells in non-activated Mph cultures, without affecting significantly CD14 + (LPS co-receptor), CD16 + (FcγRIII, low-affinity Fc-receptor), CD119 + (interferon-gamma receptor 1), and CD124 + (IL4 receptor α-subunit) cells. In addition, GM-CSF reduced relative numbers of CD197 + cells, as well as CD14 + , CD16 + , and CD119 + cells in activated Mph cultures without affecting CD124 + cell distribution. GM-CSF at the highest dose of 10 ng/ml enhanced TNF-α and IL-6 (but not IL-1β and IL-10) production in activated Mc/Mphs. In activated T cell cultures, GM-CSF at 0.1-1.0 ng/ml augmented CD38 + cell numbers in naïve СD45RA + /СD197 + and central memory СD45RA − /СD197 + cell subsets, with no effect on effector СD45RA − /СD197 − and terminally differentiated effector СD45RA + /СD197 − cells. GM-CSF at a low dose (0.01 ng/ml) down-regulated INF-γ production, while at a high dosage (10.0 ng/ml) up-regulated IL-2 and IL-4 production. Conclusion:In general, the results suggest that GM-CSF is able to facilitate the implication of both Mph and T cells in the adaptive immunogenesis.

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Erythropoietin exerts direct immunomodulatory effects on the cytokine production by activated human T-lymphocytes

Cited by 13 publications

References 24 publications

Immunological Effects of a Single Hemodialysis Treatment

Immunological Effects of a Single Hemodialysis Treatment

In vitro modifying effect of erythropoietin upon thymic lymphocytes: an inhibitor analysis

Directs effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on adaptive immunogenesis

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