Erythropoietin downregulates red blood cell clearance, increasing transfusion efficacy in severely anemic recipients
Madeleine Casimir,
Martin Colard,
Michael Dussiot
et al.
Abstract:Red blood cells (RBC) transfusion is used to alleviate symptoms and prevent complications in anemic patients by restoring oxygen delivery to tissues. RBC transfusion efficacy, that can be measured by a rise in hemoglobin (Hb) concentration, is influenced by donor‐, product‐, and recipient‐related characteristics. In some studies, severe pre‐transfusion anemia is associated with a greater than expected Hb increment following transfusion but the biological mechanism underpinning this relationship remains poorly … Show more
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