Erythropoietin and IL-3 Induce Tyrosine Phosphorylation of CrkL and Its Association with Shc, SHP-2, and Cbl in Hematopoietic Cells

Chin, Hiroshi; Saitô, Takako; Arai, Ayako; Yamamoto, Koh; Kamiyama, Ryuichi; Miyasaka, Nobuyuki; Miura, Osamu

doi:10.1006/bbrc.1997.7480

Cited by 59 publications

(60 citation statements)

References 34 publications

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“…Certain cytokines and di erentiation factors, for example erythropoietin (Epo) also lead to Cbl phosphorylation and the formation of Cbl ± CRKL complexes Chin et al, 1997;and others). More recently, Cbl phosphorylation and complex formation was also reported for non-haematopoietic cells in response to hepatocyte growth factor (HGF)-activation of the c-Met tyrosine kinase receptor and in cells transfected with the transforming fusion protein Tpr-Met (Garcia-Guzman et al, 2000).…”

Section: Paxillinmentioning

confidence: 99%

“…CRKL is also recruited into this complex (reviewed in Wojchowski et al, 1999). The situation is therefore reminiscent of c-Cbl, which also binds to Crk when it is tyrosine phosphorylated after Epo-stimulation of cells Chin et al, 1997). Again the functional consequences of Gab ± Crk/CRKL complexes in haematopietic cells are not well understood yet.…”

Section: Gab Proteinsmentioning

confidence: 99%

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Crk family adaptors–signalling complex formation and biological roles

2001

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Section: Paxillinmentioning

confidence: 99%

Section: Gab Proteinsmentioning

confidence: 99%

Crk family adaptors–signalling complex formation and biological roles

2001

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“…For example, lck, which is expressed predominantly in hematopoietic cells, has been shown to activate the JAK/STAT pathway in T lymphocytes and to induce STAT3 tyrosine phosphorylation and DNA binding (Lund et al, 1997(Lund et al, , 1999Yu et al, 1997). Lyn, another hematopoietic SFK, plays an essential role in activation of the STAT5 pathway by the cytokine, erythropoietin (Chin et al, 1998). A series of in vitro studies in insect cells, showed that src, hck, lyn, fyn, and (STAT) are activated by cytokine and growth factor receptors.…”

Section: Stat Activation By Other Sfksmentioning

confidence: 99%

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

2004

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“…Another protein that feeds into the PI3K-PKB/AKT pathway is the Cbl protein, which also docks onto the adaptor protein Grb2 and Shc. Tyrosine phosphorylation of Cbl has been observed in IL-3-and GM-CSF-stimulated cells which leads to activation of the PI3K pathway (Odai et al, 1995;Anderson et al, 1997;Barber et al, 1997;Chin et al, 1997;Sattler et al, 1996).…”

Section: Pi3k-pkb/akt Pathwaymentioning

confidence: 99%

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

et al. 2000

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Hematopoiesis is the cumulative result of intricately regulated signal transduction cascades that are mediated by cytokines and their cognate receptors. Proper culmination of these diverse signaling pathways forms the basis for an orderly generation of di erent cell types and aberrations in these pathways is an underlying cause for diseases such as cancer. Over the past several years, downstream events initiated upon cytokine/ growth factor stimulation have been a major focus of biomedical research. As a result, several key concepts have emerged allowing a better understanding of the complex signaling processes. A group of novel transcription factors, termed signal transducers and activators of transcription (STATs) appear to orchestrate the downstream events propagated by cytokine/growth factor interactions with their cognate receptors. Until recently, the JAK proteins were considered to be the tyrosine kinases, which dictated the levels of phosphorylation and activation of STAT proteins, forming the basis of the JAK-STAT model. However, over the past few years, increasing evidence has accumulated which indicates that at least some of the STAT protein activation may be mediated by members of the Src gene family following cytokine/growth factor stimulation. Studies have demonstrated that the Src-family of tyrosine kinases can phosphorylate and activate certain STAT proteins, in lieu of JAK kinases. In such a scenario, JAK kinases may be more crucial to phosphorylation of the cytokine/growth factor receptors and in the process create docking sites on the receptors for binding of SH2-containing proteins such as STATs, Src-kinases and other signaling intermediates. Tyrosine phosphorylation and activation of STAT proteins can be achieved either by JAKs or Src-kinases depending on the nature of STAT that is being activated. This forms the basis for the JAK-Src-STAT model proposed in this review. The concerted action of JAK kinases, members of the Src-kinase family and STAT proteins, leads to cell proliferation and cell survival, the end-point of the cytokine/growth factor stimulus.

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Erythropoietin and IL-3 Induce Tyrosine Phosphorylation of CrkL and Its Association with Shc, SHP-2, and Cbl in Hematopoietic Cells

Cited by 59 publications

References 34 publications

Crk family adaptors–signalling complex formation and biological roles

Crk family adaptors–signalling complex formation and biological roles

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

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