Erythropoietic Function in Uremic Rabbits

The Influence of Environment on Iron Incorporation and Mitotic Division in a Suspension of Normal Bone Marrow*

“…As in inflammatory disorders, a shortening of the red-cell life span may be contributory to this anaemia, but the major reason for the anaemia appears to be a functional failure of the erythropoietic tissue (Loge, Lange and Moore, 1958;Kaye, 1958). A number of recent studies have shown that bilateral nephrectomy is associated with a profound suppression in the production or release of erythropoietic factor Erslev, 1958) and consequently in stem-cell differentiation, but whether this suppression is due to azotaemia per se, or to the absence of normal renal tissue, has not been resolved.…”

Effect of Erythropoietin Therapy on the Red Cell Volume of Uraemic and Non‐uraemic Rats

“…The significance of these results is discussed.The anaemia of chronic renal disease remains a therapeutic problem which is unlikely to be solved until erythropoietin (Ep) becomes available in pure form on a large scale. However, the observation that uraemic plasma contains inhibitors of haem synthesis (Markson & Rennie, 1956; Moriyama et al, 1975) and of erythroid colony forming units (CFU-E) growth in vitro ; and that animals with acute uraemia produced by bilateral nephrectomy (Erslev, 1958;Reissmann et al, 1960;Bozzini et al, 1966) respond poorly to Ep raises serious doubts regarding the value of erythropoietin therapy in patients with chronic renal failure. These doubts are reinforced by the results of studies suggesting that patients with chronic renal failure respond suboptimally to crude Ep-containing preparations (Van Dyke et al, 1963 ; Essers et al, 1973).In 1932 Chanutin & Ferris showed that removal offive-sixths of the renal mass of rats in a two-stage procedure caused them to become uraemic and anaemic, and to remain so for a period of over a month.…”

Management of Acute Renal Failure

“…19 Furthermore, bleeding from the intestinal tract is a frequent complication in uremia. This is a serious contribution to the elevation of the BUN and serum potassium.…”