Erythropoietic Effect of Plasma from Mice receiving Testosterone

Fried, Walter; Gurney, Clifford W.

doi:10.1038/2061160a0

Cited by 80 publications

(21 citation statements)

References 10 publications

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“…This is in accord with reported observations that little, if any, transplacental passage of DT, L-T4, and Ep occurs in sheep (29,30). Stimulation of erythropoiesis in the adult by DT and L-T4 has been well documenited (21)(22)(23)(31)(32)(33)(34). Like the fetus, the erythropoietic response of the adult to these hormones is mediated by Ep (31,33,34).…”

Section: Discussionmentioning

confidence: 99%

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Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

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A B S T R A C T The effect of testosterone (DT) and thyroxin (L-T4) on erythropoiesis and erythropoietin (Ep) These data demonstrate that (a) DT aind L-T4 are effective promnoters of extrarenal Ep production, thereby enhancing erythropoiesis in intact and nephrectomized fetuses; (b) DT is a stronger stimulus of extrarenal Ep formation than L-T4; and (c) Ep is required for the expression of the erythropoietic effects of L-T4 and DT.

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Section: Discussionmentioning

confidence: 99%

“…It is now firmly established that the erythropoietic effect(s) of androgens is mediated, at least in part, through increased production of Ep (21)(22)(23). Studies employing nephrectomized adult animals have shown that this effect is dependent on the presence of kidneys (24).…”

Section: Introductionmentioning

confidence: 99%

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

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“…Naturally occurring androgen, as well as synthetic androstanes with predominantly anabolic properties, stimulate EP production [7,53,113,139], This apparently is accomplished by sensitizing the kidneys, and perhaps to a far lesser extent the extrarenal sites, to hypoxic stimuli [55,70]. As a consequence more EP is produced in response to any given hypoxic stimulus than is the case in comparably hypoxic animals which do not receive androgens.…”

Section: Effects O F Hormones and Ollier Substances On Erythropoietinmentioning

confidence: 99%

“…Another example of a phenomenon not completely explained by the hypo thesis that EP production and erythropoiesis are regulated by the relative oxygen supply to tissues is the 'compensated hemolytic slate' [53]. This con sists of conditions in which red cell production is increased several-fold in association with hemolysis.…”

Section: Factors Which Affect Erythropoietin Production In Renal and mentioning

confidence: 99%

Erythropoietm and the Kidney

Fried¹

1975

Nephron

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Erythropoietin is a polypeptide hormone, which is produced in response to a deficit in the delivery of oxygen to the tissues relative to their oxygen needs; although other feedback mechanisms also modulate its production. The kidneys play a major role in the elaboration of this hormone. However, the precise action of the kidney is not yet known. Diseases of the kidneys cause profound alteration in the normal regulation of erythropoiesis. Some of these are reviewed here.

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“…Studies 57,58,59 demonstrate that in rats, a decrease in erythropoietin occurred due to the reduced ingestion of protein. Data from our laboratory evidence that the anaemia found in adult mice, submitted to protein malnutrition is not due to iron deficiency, as the serum concentration of iron in these animals was found to be high, as were the levels of transferrin saturation and ferritin concentration in the bone marrow, liver and spleen.…”

Section: Malnutrition and Erythropoiesis: Anaemiamentioning

confidence: 99%