Erythropoietic activity of Asteracantha longifolia (Nees.) in rats

Pawar, Rajesh Singh; Jain, Alok Pal; Lodhi, Santram; Singhai, A. K.

doi:10.1016/j.jep.2010.03.015

Cited by 9 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cardiovascular Health a blood: The chloroform, ethanolic extract of the leaf able to restore a level of blood cells and bone marrow cells in rats which induced by cyclophosphamide-anemia. However, ethanolic extract not in rats are not feeble and assumed to stimulate erythropoiesis and is encountered with a small (possibly clinically irrelevant) decline relative to untreated control [27] .…”

Section: Antioxidant Activitymentioning

confidence: 99%

Ethnopharmacolological potential and medicinal uses of Hygrophila auriculata

Sarvananda¹,

Premarathna²

2018

J. Ayu. Her. Med.

View full text Add to dashboard Cite

Hygrophila auriculata is belonging to family Acanthaceae, Usually called as "Neermulli in Tamil" is a grow in wet places.It is an important herbal plant, broadly spread in Sri Lanka India, and is used to treat various diseases. Hygrophila auriculata (L.) Nees, Acanthaceae, is a source of traditional medicine; the aerial parts of the plant are used to treat blood disorders. It has various medicinal properties such as anticancer, hypoglycemic, aphrodisiac, antimicrobial, antioxidant, lipid peroxidation, hepatoprotective and hematopoietic activity. It consists of lupeol, stigmasterol, bulletin, fatty acids, and alkaloids. Commercially, it used as an ingredient in some of over the counter (OTC) formulations to treat the liver disorder and those prescribed by general tonic. In this review, talk over the pharmacological and medicinal properties of Hygrophila auriculata (Neermulli). Furthermore, need to do a clinical investigation to promote as commercial drugs.

show abstract

Section: Antioxidant Activitymentioning

confidence: 99%

Ethnopharmacolological potential and medicinal uses of Hygrophila auriculata

Sarvananda¹,

Premarathna²

2018

J. Ayu. Her. Med.

View full text Add to dashboard Cite

show abstract

“…Hygrophila spinosa, Hygrophila auriculata) is a wild herb of medicinal value, widely distributed in India and used by the local population for different medicinal purposes. It possesses potent antioxidant and erythropoietic activities Pawar et al [6] and is used in 'Ayurveda' as a 'Rasayana' drug for treatment of various disorders Vijaykumar, et al [7] Ahmed et al [8] reported the anti-tumor promoting potential of the methanol fraction of the A. longifolia seed extract against chemically-induced hepatocarcinogenesis in Wistar rats. However, there are no studies reported on the effect of A. longifolia whole plant extract against chemically induced mammary carcinogenesis in rats.…”

Section: Original Articlementioning

confidence: 99%

Evaluation of anticancer activity of Asteracantha longifolia in 7,12-Dimethylbenz(a)anthracene-induced mammary gland carcinogenesis in Sprague Dawley rats

Nair

Shridhar

Jayakumar

2015

Int J Nutr Pharmacol Neurol Dis

View full text Add to dashboard Cite

Ethnopharmacological Relevance: Asteracantha longifolia Nees. (Syn. Hygrophila spinosa, Hygrophila auriculata) is a common weed growing in marshy and water logged areas. It is an important medicinal herb, widely distributed in India, and used by the local population for different medicinal purposes. In Ayurveda, the plant parts are used for the treatment of rheumatism, urinary tract infection, malaria, inflammation, diabetes, dysentery, jaundice, hepatic obstruction, pain, and decreased libido. Aim: The objective of the study is to explore the anticancer activity of the methanolic extract of A. longifolia on 7,12-Dimethylbenz (a) anthracene (DMBA)-induced mammary carcinogenesis in rats. Materials and Methods: The anticancer activity of the methanolic whole plant extract of A. longifolia was evaluated in Sprague Dawley rats in the mammary tumor induced by DMBA. The doses administered were 100, 200, and 400 mg/kg body weight by oral route. The extracts were administered for 20 consecutive days. The tumor size was determined before and after the administration of the plant extract and compared with the antitumor effect of the standard drug cyclophosphamide (CYC). After the experiment, the rats were sacrificed and subjected to histopathology and biochemical analysis. Results: A. longifolia extracts showed a significant (P < 0.05) decrease in the tumor size of DMBA-induced mammary tumor in mice. The extracts significantly (P < 0.05) decreased the levels of lipid peroxidation and significantly (P < 0.05) increased the levels of superoxide dismutase and catalase. Phytochemical screening revealed the presence of flavanoids, which are potent antioxidants. Conclusion: The results showed that the methanolic extract of A. longifolia was more effective in inhibiting the tumor growth and safe in DMBA-induced mammary tumor in rats as compared to the standard drug, cyclophosphamide.

show abstract