Erythropoiesis and Conversion of RBCs and Hemoglobins from Larval to Adult Type during Amphibian Development

Wakahara, Masami; Yamaguchi, Masahiro

doi:10.2108/zsj.18.891

Cited by 8 publications

(3 citation statements)

References 87 publications

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“…This switching enables a more efficient gas exchange in juvenile rainbow trout in comparison to larval animals, with greater Bohr effect in adult haemoglobins (82). During amphibian metamorphosis, there is a similar regulation of haemoglobins, and the evidence seems to suggest that this event occur so that the metamorphosed animal can adapt to the new post-metamorphic environment (85, 86).…”

Section: Bloodmentioning

confidence: 99%

Teleost Metamorphosis: The Role of Thyroid Hormone

Campinho¹

2019

Front. Endocrinol.

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In most teleosts, metamorphosis encompasses a dramatic post-natal developmental process where the free-swimming larvae undergo a series of morphological, cellular and physiological changes that enable the larvae to become a fully formed, albeit sexually immature, juvenile fish. In all teleosts studied to date thyroid hormones (TH) drive metamorphosis, being the necessary and sufficient factors behind this developmental transition. During metamorphosis, negative regulation of thyrotropin by thyroxine (T4) is relaxed allowing higher whole-body levels of T4 that enable specific responses at the tissue/cellular level. Higher local thyroid cellular signaling leads to cell-specific responses that bring about localized developmental events. TH orchestrate in a spatial-temporal manner all local developmental changes so that in the end a fully functional organism arises. In bilateral teleost species, the most evident metamorphic morphological change underlies a transition to a more streamlined body. In the pleuronectiform lineage (flatfishes), these metamorphic morphological changes are more dramatic. The most evident is the migration of one eye to the opposite side of the head and the symmetric pelagic larva development into an asymmetric benthic juvenile. This transition encompasses a dramatic loss of the embryonic derived dorsal-ventral and left-right axis. The embryonic dorsal-ventral axis becomes the left-right axis, whereas the embryonic left-right axis becomes, irrespectively, the dorsal-ventral axis of the juvenile animal. This event is an unparalleled morphological change in vertebrate development and a remarkable display of the capacity of TH-signaling in shaping adaptation and evolution in teleosts. Notwithstanding all this knowledge, there are still fundamental questions in teleost metamorphosis left unanswered: how the central regulation of metamorphosis is achieved and the neuroendocrine network involved is unclear; the detailed cellular and molecular events that give rise to the developmental processes occurring during teleost metamorphosis are still mostly unknown. Also in flatfish, comparatively little is still known about the developmental processes behind asymmetric development. This review summarizes the current knowledge on teleost metamorphosis and explores the gaps that still need to be challenged.

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Section: Bloodmentioning

confidence: 99%

Teleost Metamorphosis: The Role of Thyroid Hormone

Campinho¹

2019

Front. Endocrinol.

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“…These morphological changes are scarcely less profound than those of amphibian metamorphosis but are clearly distinct from them. On the other hand, some of the biochemical and physiological changes that accompany metamorphosis, such as switching of globin (Wakahara and Yamaguchi, 2001;Miwa and Inui, 1991) and keratin (Campinho et al, 2007a) types and the production of new isoforms of muscle proteins (Yamano et al, 1991a;Campinho et al, 2007b) are similar in flatfish and amphibia. Still more significantly, there is strong evidence that thyroid hormones regulate metamorphosis in flatfish in much the same manner as in amphibia.…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)

Galay-Burgos

Power

Llewellyn

et al. 2008

Molecular and Cellular Endocrinology

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Flatfish such as the Atlantic halibut (Hippoglossus hippoglossus) undergo a dramatic metamorphosis that transforms the pelagic, symmetric larva into a benthic, cranially asymmetric juvenile. In common with amphibian metamorphosis, flatfish metamorphosis is under endocrine control with thyroid hormones being particularly important. In this report we confirm that tri-iodothyronine (T 3 ) levels peak at metamorphic climax during halibut metamorphosis. Moreover we have isolated cDNA clones of TR and TR genes and confirmed the presence in halibut of two TR isoforms (representing the products of distinct genes) and two TR isoforms (generated from a single gene by alternative splicing). Real time PCR was used to assess expression of these genes during metamorphosis. TR shows the most dramatic expression profile, with a peak occurring during metamorphic climax.

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“…It is well known that embryonic hemoglobin is present in vertebrates such as mammals (Proudfoot et al, 1982), birds (Chapman andHood, 1982) and amphibians (Wakahara and Yamaguchi, 2001), and the hemoglobin has been extensively investigated (Collins and Weissman, 1984). We first identified and characterized embryonic hemoglobin in rainbow trout Oncorhynchus mykiss (Iuchi and Yamagami, 1969;Iuchi, 1973Iuchi, , 1985 it was originally called larval hemoglobin, HbL), and recently we cloned two a and two b globin cDNAs from the trout embryos (Maruyama et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Evolution of globin genes of the medaka Oryzias latipes (Euteleostei; Beloniformes; Oryziinae)

Maruyama

Yasumasu

Iuchi

2004

Mechanisms of Development

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Recently we cloned two globin gene clusters from the genome of medaka (Oryzias latipes): one designated the embryonic globin gene cluster (E1; (5')alpha0(3')-(3')beta1(5')-(5')alpha1(3')-(5')beta2(3')-(5')alpha2(3')-(3')alpha3(5')-(5')beta3(3')-(3')beta4(5')-(5')alpha4(3')-(3')psialpha(5')-(5')psibeta(3')) and the other the adult globin gene cluster (A1; (3')ad.alpha1(5')-(5')ad.beta1(3')-(3')ad.alpha2(5')). The E1 and A1 clusters map to linkage groups 8 and 19, respectively. The genes beta1/alpha1, alpha3/beta3, beta4/alpha4, psialpha/psibeta and ad.alpha1/ad.beta1 are organized in head-to-head orientation with respect to transcriptional polarity. The genes alpha0, alpha1 and alpha2 are arranged in tandem with the same orientation. The results suggest that a variety of events occurred in globin gene evolution such as chromosomal translocation, duplication of alpha/beta-paired genes, tandem duplication of single alpha genes and the transformation of one pair of alpha/beta-paired genes into pseudogenes (psialpha/psibeta). Amino acid sequences predicted from the genes were compared with those of 42 alpha and 55 beta teleostean globins using the neighbor-joining or maximum likelihood methods. The phylogenetic trees that were generated classified the teleostean globins into at least four groups, tentatively named 'Embryonic Hb Group (I)', 'Notothenioid Major Adult Hb Group (II)', 'Anodic Adult Hb Group (III)' and 'Cathodic Adult Hb Group (IV)'. The medaka genes alpha0, beta1, alpha1, alpha2, alpha3, beta3, beta4 and alpha4 belong to group I, and ad.alpha1 and ad.beta1 to group II. Further analysis suggests that psialpha/psibeta and beta2/ad.alpha2 belong to groups III and IV, respectively. Thus, globin genes in the medaka probably were diversified from four ancestral genes, one for each group. On the basis of the gene comparisons, we present a hypothetical pathway for globin gene evolution in the medaka.

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Erythropoiesis and Conversion of RBCs and Hemoglobins from Larval to Adult Type during Amphibian Development

Cited by 8 publications

References 87 publications

Teleost Metamorphosis: The Role of Thyroid Hormone

Teleost Metamorphosis: The Role of Thyroid Hormone

Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)

Evolution of globin genes of the medaka Oryzias latipes (Euteleostei; Beloniformes; Oryziinae)

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