Erythroplasia of Queyrat treated with topical 5-fluorouracil

Antônio, Joäo Roberto; Antônio, Carlos Roberto; Trídico, Lívia Arroyo; Alves, Fernanda; Rollemberg, Ivan

doi:10.1590/abd1806-4841.20164595

Cited by 8 publications

(3 citation statements)

References 7 publications

(13 reference statements)

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“…3 Biopsy is essential to confirm diagnose and to exclude invasive growth. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, 6 imiquimod cream, 7 isotretinoin, 8 cryotherapy, 9 laser therapy, 10 radiotherapy, 11 ingenol mebutate gel (but recently suspended by EMA). 12 Most of these treatments are limited by low clearance rates and frequent relapses.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

et al. 2020

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Erythroplasia of Queyrat (EQ) is an intraepidermal carcinoma in situ presenting clinically as a sharply demarcated, slightly raised erythematosus plaque on the glans penis or the inner side of the foreskin. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, imiquimod cream, isotretinoin, cryotherapy, laser therapy, radiotherapy, ingenol mebutate gel and photodynamic therapy (PDT). Most of these treatments are limited by low clearance rates and frequent relapses. Surgical treatment including local excision, Mohs micrographic surgery and partial or total penectomy, ensures adequate healing rates. However, discomfort consequent to surgical treatment might be unacceptable. Topical PDT using the methyl ester of 5-aminolaevulinic acid (MAL) is an established non-surgical treatment of cutaneous precancerous lesions and skin cancers. We present the case of a 60-year-old uncircumcised man affected by EQ of the penis successfully treated with MAL-PDT, performed five times, two weeks apart, with no recurrences after 6 years.

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Section: Discussionmentioning

confidence: 99%

Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

et al. 2020

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“…Treatment options include a combination of photodynamic and topical therapy with 5% imiquimod cream versus 5-FU, phototherapy, laser therapy, or local resection. 87,88,90 A pathological assessment for surgical margins is critical to decrease risk of recurrence. Total glansectomy with resurfacing has been shown to have the lowest rate of recurrence at 2% for treatment of small lesions.…”

Section: Bowenoid Papulosismentioning

confidence: 99%

“…Management of penile EoQ often depends on the patient’s clinical status and comorbidities. Treatment options include a combination of photodynamic and topical therapy with 5% imiquimod cream versus 5‐FU, phototherapy, laser therapy, or local resection 87,88,90 . A pathological assessment for surgical margins is critical to decrease risk of recurrence.…”

Section: Premalignant Balanitismentioning

confidence: 99%

Urologic dermatology: a comprehensive foray into the noninfectious etiologies of balanitis

et al. 2021

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Balanitis is classically defined as inflammation of the glans penis, often also encompassing the prepuce (balanoposthitis). Several investigations have found that a sizable proportion of urology clinic visits are due to balanitis or related complaints. Balanitis can have numerous complications, including severe pain, urethral stenosis, phimosis, sexual dysfunction, and if untreated, malignancy. Unfortunately, there is no recent or comprehensive review that describes the various etiologies, clinical workup, and treatments for balanitis. Herein this review, we attempt to provide the reader with a complete and updated guide to balanitis in an attempt to improve clinical outcomes. Dogra et al, 69 Calcineurin Inhibitors -Tacrolimus ointment 0.3 mg/g Malignancy risk Ly et al., 71 Blauvelt et al. 70 Monoclonal Antibodies -Ustekinumab -45mg/90mg depending on weight; Secukinumab -300 mg Infection, malignancy, GI upset

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Principles of Topical Therapy

Buckley

2024

Rook's Textbook of Dermatology

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As well as quantifying the burden of skin disease, epidemiology provides a direct method for assessing the causes of skin diseases. Identification of causes is a necessary step in pursuing the ultimate goal of disease prevention. This chapter covers the importance of thinking in terms of population rather than individuals, and provides a summary of the substantial global morbidity caused by skin disease. Risk factors from genetics to environment are outlined, along with describing the natural history and associations of common skin diseases. Finally, there is a description of how the principles and data from epidemiological studies provide the cornerstone to planning appropriate dermatology services. The chapter closes by providing the reader with a glossary of terms and a checklist to help with reading epidemiological studies.

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Erythroplasia of Queyrat treated with topical 5-fluorouracil

Cited by 8 publications

References 7 publications

Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

Urologic dermatology: a comprehensive foray into the noninfectious etiologies of balanitis

Principles of Topical Therapy

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