Erythromycin therapy in bullous pemphigoid: Possible anti-inflammatory effects

Fox, Barbara J.; Odom, Richard B.; Findlay, Robert F.

doi:10.1016/s0190-9622(82)70133-1

Cited by 66 publications

(15 citation statements)

References 18 publications

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“…In this regard, there is one report of erythromycin being used as an adjunctive agent for its antichemotactic effect on neu¬ trophils, with perceived benefit. 16 In two severe cases, in which management was complicated by concomitant ulcerative colitis and membranous glomerulonephropathy, respectively, the addition of azathioprine to corticosteroid therapy was found useful.5,8 Control of pruri¬ tus, the prompt treatment of secondary bacterial infection, and attention to glucose and electrolyte lev¬ els, and protein metabolism should also be of para¬ mount concern.…”

Section: Report Of a Casementioning

confidence: 99%

Childhood Bullous Pemphigoid

et al. 1991

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A 2 1/2-month-old female infant presented with multiple tense bullae on the hands and feet. Analysis of biopsy specimens confirmed our clinical impression of childhood bullous pemphigoid. Confirmatory data included type IV collagen mapping of the basement membrane zone, a readily available technique that helps distinguish childhood bullous pemphigoid from childhood epidermolysis bullosa acquisita. To our knowledge, our patient is the youngest described with childhood bullous pemphigoid, and we use this opportunity to review the literature and examine the clinical and immunologic features, treatment, and prognosis of this rare childhood immunobullous disorder.

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Section: Report Of a Casementioning

confidence: 99%

Childhood Bullous Pemphigoid

et al. 1991

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“…Altomare et al [53] reported that the macrolide antibiotic erythromycin has been effective in bullous pemphigoid in their studied patients. Fox et al [54] reported two patients with bullous pemphigoid treated with erythromycin demonstrated improvement.…”

Section: Introductionmentioning

confidence: 99%

Macrolides in Chronic Inflammatory Skin Disorders

Alzolibani

Zedan

2012

Mediators of Inflammation

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Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.

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“…Fox et al. 3 reported coincidental improvement with oral erythromycin when used alone in a 4.5‐year‐old girl with BP. Adjunctive or single treatment with erythromycin has been rarely reported in childhood 4 .…”

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confidence: 98%