Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance

Wan, Jingjing; Qin, Zhen; Hong, Lei; Wang, Pengyuan; Feng, Jiayi; Wei, Jie; Sun, Yang; Liu, Xia

doi:10.1016/j.phrs.2020.105118

Cited by 10 publications

(23 citation statements)

References 56 publications

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“…They evaluated several macrolides' effect and mechanisms in muscle endurance, in order to provide potential treatments for muscle fatigue. They demonstrated that erythromycin, dose-dependently, mitigates muscle fatigue, increases ORM levels and elevates glycogen content in muscle in a mice model [238]. Moreover, they corroborated that erythromycin enhances muscle glycogen and endurance via upregulating ORM and activating ORM-mediated CCR5-AMPK-GS pathway.…”

Section: Muscle Fatiguementioning

confidence: 75%

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Mitochondria and Antibiotics: For Good or for Evil?

et al. 2021

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The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed.

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Section: Muscle Fatiguementioning

confidence: 75%

“…Inhibit cancer proliferation [40,134] Mitigates muscle fatigue [238] AMPK activation [238] Mitochondrial membrane potential disruption [36] ROS production [260] Cytochrome c release [261] 500 250…”

Section: Azithromycin Macrolidementioning

confidence: 99%

Mitochondria and Antibiotics: For Good or for Evil?

et al. 2021

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“…Although the value seems small, the logistic analysis based on this dataset showed that after BCT, recruits with ΔORM ≥ 0.2565 mg/mL had higher odds for suffering from severe EIF, as 5.625 times as large than those with ΔORM < 0.2565 mg/mL, which also revealed its potency as a promising biomarker. Previous studies reported that ORM could interact with skeletal muscle and inhibit protein breakdown [ 53 ], and increase muscle bioenergetics and sustain physiological endurance via upregulating the ATP production through AMPK signalling pathway [ 17 , 54 ]. When recruits felt exhausted (severe EIF during BCT), the energy supply was likely to be under compensation stage, therefore may triggered the increase of ORM.…”

Section: Discussionmentioning

confidence: 99%

Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training

Ruan

Xiang

Zhang

et al. 2022

BMC Sports Sci Med Rehabil

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Background Orosomucoid (ORM) is a positive acute phase protein verified to be upregulated in various forms of exercise-induced fatigued (EIF) rodents. However, its association with EIF among human beings remained unknown. This study aimed to explore the association between serum ORM and EIF triggered by military basic combat training (BCT). Methods The degree of EIF were measured by Borg’s Rating of Perceived Exertion Scale (Borg-RPE-Scale®) as RPE score after BCT. Fifty-three male recruits were classified into three groups according to the RPE score: (1) group 1 (slight fatigue group): RPE score after BCT < 13; (2) group 2 (moderate fatigue group): RPE score after BCT = 13 or 14; (3) group 3 (severe fatigue group): RPE score after BCT > 14. The levels of blood ORM, lactate (LAC), cortisol and C-reactive protein (CRP) were determined before and after BCT. The diagnostic value of ORM was evaluated by receiver operating characteristic (ROC) curve analysis and logistic regression. Results After BCT, the level of LAC, CRP, and cortisol increased among all groups, but the changes had no significant between-group difference (all p > 0.05). The level of ORM had a specific significant increase in group 3 (p = 0.039), and the changes of ORM (ΔORM) had significant difference among groups (p = 0.033). ROC curve analysis showed that the estimated area under ROC curve for ΔORM was 0.724 (p = 0.009) with the recommended optimal cut-off value as 0.2565 mg/mL. Logistic analysis showed that recruits with ΔORM ≥ 0.2565 mg/mL had higher odds for suffering from severe EIF, 5.625 times (95% CI 1.542–20.523, p = 0.009) as large as those with ΔORM < 0.2565 mg/mL. Conclusion ORM might be a promising biomarker of severe EIF triggered by BCT among male recruits. Its potential optimal cut-off value regarding ΔORM was recommended to be 0.2565 mg/mL.

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“…Later, the same group showed that AGP1-CCR5 increased the activity of glycogen synthase (the ratelimiting enzyme in the glycogen synthesis pathway) via AMPKα2 (Qin et al, 2016). Further, they identified estrogens (as a negative) and erythromycin (as a positive) regulators of the AGP1-CCR5 pathway (Sun et al, 2018;Wan et al, 2020). Interestingly, Orm1-KO mice show altered metabolic parameters, such as increased levels of insulin and leptin together with impaired glucose tolerance (Sun et al, 2016) and AGP1 deficiency increases the expression of genes related to fibrosis in adipose tissue (Wang et al, 2021).…”

Section: In Vivo Approaches Transgenesis and Knockoutsmentioning

confidence: 99%

“…Later, the same group showed that AGP1-CCR5 increased the activity of glycogen synthase (the rate-limiting enzyme in the glycogen synthesis pathway) via AMPKα2 ( Qin et al, 2016 ). Further, they identified estrogens (as a negative) and erythromycin (as a positive) regulators of the AGP1-CCR5 pathway ( Sun et al, 2018 ; Wan et al, 2020 ).…”

Section: In Vivo Approaches Transgenesis and Knockoutsmentioning

confidence: 99%

Into the Labyrinth of the Lipocalin α1-Acid Glycoprotein

Ruiz

2021

Front. Physiol.

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α1-acid glycoprotein (AGP), also known as Orosomucoid (ORM), belongs to the Lipocalin protein family and it is well-known for being a positive acute-phase protein. AGP is mostly found in plasma, with the liver as main contributor, but it is also expressed in other tissues such as the brain or the adipose tissue. Despite the vast literature on AGP, the physiological functions of the protein remain to be elucidated. A large number of activities mostly related to protection and immune system modulation have been described. Recently created AGP-knockout models have suggested novel physiological roles of AGP, including regulation of metabolism. AGP has an outstanding ability to efficiently bind endogenous and exogenous small molecules that together with the complex and variable glycosylation patterns, determine AGP functions. This review summarizes and discusses the recent findings on AGP structure (including glycans), ligand-binding ability, regulation, and physiological functions of AGP. Moreover, this review explores possible molecular and functional connections between AGP and other members of the Lipocalin protein family.

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Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance

Cited by 10 publications

References 56 publications

Mitochondria and Antibiotics: For Good or for Evil?

Mitochondria and Antibiotics: For Good or for Evil?

Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training

Into the Labyrinth of the Lipocalin α1-Acid Glycoprotein

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