Erythromycin degradation and ERY-resistant gene inactivation in erythromycin mycelial dreg by heat-activated persulfate oxidation

Zhang, Yanxiang; Liu, Huiling; Xin, Yanjun; Shen, Yunpeng; Wang, Jing; Cai, Chen; Wang, Mengmeng

doi:10.1016/j.cej.2018.10.157

Cited by 54 publications

(7 citation statements)

References 46 publications

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“…, Fenton-like processes, carbocatalytic ozonation, and UV-based AOPs). 333,334 The latest metal-free AOPs for ARG removal are summarized in Table 8.…”

Section: Reduction Of Args By Metal-free Catalyzed Aopsmentioning

confidence: 99%

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Recent advances in metal-free catalysts for the remediation of antibiotics, antibiotic resistant bacteria (ARB), and antibiotic resistant genes (ARGs)

Wang

Ding

et al. 2022

J. Mater. Chem. A

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“…, Fenton-like processes, carbocatalytic ozonation, and UV-based AOPs). 333,334 The latest metal-free AOPs for ARG removal are summarized in Table 8.…”

Section: Reduction Of Args By Metal-free Catalyzed Aopsmentioning

confidence: 99%

“…SO 4 ˙ − -based AOPs were also deemed highly-selective oxidation processes, which might apply to ARG inactivation. 342 For example, Zhang et al 334 demonstrated that SO 4 ˙ − produced by heat-activated PS could significantly reduce ARGs ( i.e. , ereB , ermA , and ermB ).…”

Section: Reduction Of Args By Metal-free Catalyzed Aopsmentioning

confidence: 99%

Recent advances in metal-free catalysts for the remediation of antibiotics, antibiotic resistant bacteria (ARB), and antibiotic resistant genes (ARGs)

Wang

Ding

et al. 2022

J. Mater. Chem. A

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“…However, residual unextracted antibiotics limit its use due to possible ecosystem risks (Kemper, 2008). Erythromycin fermentation dregs (EFD) with 640 mg kg −1 residual erythromycin and 90% water content have raised concerns among all the AFD (Zhang et al, 2019). It could not only pose threats to living species such as Daphnia magna and Selenastrum capricornutum but also present selecting pressure of antibiotic bacteria and promote the spread of antibiotic resistant genes, if without reasonable disposal (Zhang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Erythromycin fermentation dregs (EFD) with 640 mg kg −1 residual erythromycin and 90% water content have raised concerns among all the AFD (Zhang et al, 2019). It could not only pose threats to living species such as Daphnia magna and Selenastrum capricornutum but also present selecting pressure of antibiotic bacteria and promote the spread of antibiotic resistant genes, if without reasonable disposal (Zhang et al, 2019). Moreover, the EFD is the reservoir of ARGs, for example, the relative abundance of ermB is 6.82 × 10 −4 copies/16S rRNA copies (Zhang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydrothermal Pretreatment on Anaerobic Digestion of Erythromycin Fermentation Dregs: Biogas Production, Antibiotic Resistance Gene Evolution, and Microbial Community Dynamics

Kuang

Wang

2022

Front. Environ. Sci.

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The utilization of erythromycin fermentation dregs (EFD), one kind of solid biowaste, is limited due to the high-level residue of antibiotics. Hydrothermal pretreatment (HT) has great potential to remove residual antibiotics. However, its harmless performance and influence on the EFD anerobic digestion (AD) process remains unclear. In this study, HT was conducted for erythromycin removal before EFD AD with the temperature ranging from 80 to 180°C. Moreover, changes in biogas yield, antibiotic resistance genes (ARGs), and microbial communities in the EFD AD process were compared among different treatments. The results showed that under the optimal hydrothermal temperature of 160°C, more than 85% of erythromycin was eliminated. In addition, HT significantly reduced the ARGs in the EFD AD process and ermT and mefA relative abundance decreased by one order of magnitude. Mobile genetic elements (IntI1 and Tn916/1545) also showed decreased tendency with the hydrothermal temperature elevation. The maximum methane production of 428.3 ml g−1 VS was obtained in the AD system of EFD with hydrothermal treatment at 160°C. It is attributed to the cooperation of hydrolysis and acidogenesis bacteria (e.g., Aminicenantales and Sedimentibacter) and methylotrophic methanogens (Candidatus_Methanofastidiosum and Methanosarcina), and they presented the highest relative abundance in this group. The results indicated that methylated substance reduction was the major methanogenesis route. Hydrothermal technology was of great potential to realize the harmless treatment of EFD and for recycling EFD via AD.

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“…Erythromycin mycelial dreg (EMD) is a type of antibiotic fermentation waste. EMD is mainly composed of mycelial cells, unused medium, and residual erythromycin with~90% moisture [3]. The amount of erythromycin detected in EMD demonstrates the inefficiency of the disposal processes used in pharmaceutical industries during erythromycin production [4].…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of erythromycin by Delftia lacustris RJJ‐61 and characterization of its erythromycin esterase

et al. 2020

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The residual erythromycin in fermentation waste can pollute the environment and threaten human health. However, there are no effective approaches to remedy this issue. In this study, an erythromycin‐degrading bacterium named RJJ‐61 was isolated and identified as a strain of Delftia lacustris based on morphological and phylogenetic analyses. The degradation ability of this strain was also evaluated; it could degrade 45.18% of erythromycin at 35°C in 120 h. Furthermore, the key degradation gene ereA was cloned from strain RJJ‐61 and expressed in Escherichia coli BL21; the molecular weight of the expressed protein was ~45 kDa. The enzyme activity of EreA was 108.0 mU ml−1 at 35°C and pH 7.0. Finally, the EreA protein was used to degrade erythromycin from mycelial dregs and 50% diluted solution, and the removal rates in them were 41.42% and 69.78%, respectively. In summary, D. lacustris RJJ‐61 is a novel erythromycin‐degrading strain that has great potential to remove erythromycin pollutants from the environment.

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Erythromycin degradation and ERY-resistant gene inactivation in erythromycin mycelial dreg by heat-activated persulfate oxidation

Cited by 54 publications

References 46 publications

Recent advances in metal-free catalysts for the remediation of antibiotics, antibiotic resistant bacteria (ARB), and antibiotic resistant genes (ARGs)

Recent advances in metal-free catalysts for the remediation of antibiotics, antibiotic resistant bacteria (ARB), and antibiotic resistant genes (ARGs)

Effect of Hydrothermal Pretreatment on Anaerobic Digestion of Erythromycin Fermentation Dregs: Biogas Production, Antibiotic Resistance Gene Evolution, and Microbial Community Dynamics

Biodegradation of erythromycin by Delftia lacustris RJJ‐61 and characterization of its erythromycin esterase

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