Erythromycin- and copper-resistant Enterococcus hirae from marine sediment and co-transfer of erm(B) and tcrB to human Enterococcus faecalis

Pasquaroli, Sonia; Cesare, Andrea Di; Vignaroli, Carla; Conti, Giulia De; Citterio, Barbara; Biavasco, Francesca

doi:10.1016/j.diagmicrobio.2014.06.002

Cited by 26 publications

(22 citation statements)

References 26 publications

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“…Co-transmission of the copper efflux-associated tcrB and erythromycin resistance erm (B) genes has been reported between a sediment-derived livestock species ( Enterococcus hirae) and E. faecalis in conjugation experiments [ 172 ]. From 569 Danish livestock-derived bacterial isolates tested for susceptibilities to antibiotics, biocides and heavy metals, the only distinct “less susceptible” group of organisms seen were Enterococcus spp.…”

Section: Observations On Specific Livestock-associated Bacterial Gmentioning

confidence: 99%

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

2015

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Concerns have been raised in recent years regarding co-selection for antibiotic resistance among bacteria exposed to biocides used as disinfectants, antiseptics and preservatives, and to heavy metals (particularly copper and zinc) used as growth promoters and therapeutic agents for some livestock species. There is indeed experimental and observational evidence that exposure to these non-antibiotic antimicrobial agents can induce or select for bacterial adaptations that result in decreased susceptibility to one or more antibiotics. This may occur via cellular mechanisms that are protective across multiple classes of antimicrobial agents or by selection of genetic determinants for resistance to non-antibiotic agents that are linked to genes for antibiotic resistance. There may also be relevant effects of these antimicrobial agents on bacterial community structure and via non-specific mechanisms such as mobilization of genetic elements or mutagenesis. Notably, some co-selective adaptations have adverse effects on fitness in the absence of a continued selective pressure. The present review examines the evidence for the significance of these phenomena, particularly in respect of bacterial zoonotic agents that commonly occur in livestock and that may be transmitted, directly or via the food chain, to human populations.

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Section: Observations On Specific Livestock-associated Bacterial Gmentioning

confidence: 99%

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

2015

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“…; Pasquaroli et al . ). These findings suggest the possibility of a bidirectional exchange of ARB and ARGs between environment and clinic.…”

Section: Introductionmentioning

confidence: 97%

“…On the other hand, it seems that from early on, antibiotic-resistant bacteria (ARB) in clinics arose as a consequence of the acquisition of ARGs from the environmental microbiota (Wright 2010;Walsh et al 2011b;Martinez 2012). In fact, some bacteria isolated from aquatic environments harbour ARGs as well as mobile elements, and the transfer of such genes from environmental to clinical isolates has been demonstrated in vitro Pasquaroli et al 2014). These findings suggest the possibility of a bidirectional exchange of ARB and ARGs between environment and clinic.…”

Section: Introductionmentioning

confidence: 99%

Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake

et al. 2015

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The fate of antibiotic resistance genes (ARGs) in environmental microbial communities is of primary concern as prodromal of a potential transfer to pathogenic bacteria. Although of diverse origin, the persistence of ARGs in aquatic environments is highly influenced by anthropic activities, allowing potential control actions in well-studied environments. However, knowledge of abundance and space-time distribution of ARGs in ecosystems is still scarce. Using quantitative real-time PCR, we investigated the presence and the abundance of twelve ARGs (against tetracyclines, β-lactams, aminoglycosides, quinolones and sulphonamides) at different sampling sites, depths and seasons, in Lake Maggiore, a large subalpine lake, and in the area of its watershed. We then evaluated the correlation between each ARG and a number of ecological parameters in the water column in the deepest part of the lake. Our results suggest the constitutive presence of at least four ARGs within the bacterial community with a high proportion of bacteria potentially resistant to tetracyclines and sulphonamides. The presence of these ARGs was independent of the total bacterial density and temperature. The dynamics of tet(A) and sulII genes were, however, positively correlated with dissolved oxygen and negatively to chlorophyll a, suggesting that the resistant microbes inhabit specific niches. These observations indicate that the lake is a reservoir of antibiotic resistances, highlighting the need of a deeper understanding of the sources of ARGs and the factors allowing their persistence in waters.

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“…Indeed if these genes are linked to MGEs the lateral transfer of the whole gene cluster to other bacteria is possible ( Fig. 1; N o n -c o m m e r c i a l u s e o n l y Pasquaroli et al, 2014;Silveira et al, 2014). Additionally, so called integrons can be present in MGEs.…”

Section: Co-selection Of Antibiotic and Heavy Metal Resistancementioning

confidence: 99%

Co-selection of antibiotic and heavy metal resistance in freshwater bacteria

2016

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Erythromycin- and copper-resistant Enterococcus hirae from marine sediment and co-transfer of erm(B) and tcrB to human Enterococcus faecalis

Cited by 26 publications

References 26 publications

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake

Co-selection of antibiotic and heavy metal resistance in freshwater bacteria

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