Erythrokinetische Untersuchungen mit59Fe und51Cr bei chronischen Lymphadenosen

Frischauf, H; Honetz, H.; Keibl, E

doi:10.1007/bf01632422

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The six patients were in different stages of disease, but they were all in need of treatment because of anaemia and generalized symptoms. The ;'lCr-data obtained before and during the first days of treatment indicated a reduced erythrocyte life span in all patients, in accordance with Frischauf et al (1968) who demonstrated a decreased Wr-half-time in all of their patients with CLL and anaemia. Others (Berlin 1951, Pengelly & Wilkinson 1962 have, however, found haemolysis only in a smaller proportion of their patients.…”

Section: Discussionsupporting

confidence: 83%

Haemolysis in Patients with Chronic Lymphocytic Leukaemia during Extracorporeal Irradiation of the Blood

Andersen

Karle

Dige‐Petersen

1970

Scandinavian Journal of Haematology

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Erythrocyte destruction was studied in six patients with chronic lymphocytic leukaemia treated with extracorporeal irradiation of the blood (ECI). Before treatment all patients were anaemic. 51Cr‐labelling showed an apparent half‐life of 14 to 19 days indicating a reduced erythrocyte life span. 59Fe‐data were suggestive of random destruction of erythrocytes in four of the six patients. During the later part of the ECI period considerable reticulocytosis developed, and increased disappearance rate of 51Cr‐label was evident after a mean cumulative erythrocyte dose between 18,500 and 34,000 rads had been reached. This indicates the occurrence of haemolysis which was most pronounced in the one patient with a slightly positive Coombs' test. The 59Fe‐curves were either unaffected by the irradiation or showed only minor effects; since labelling was performed immediately before treatment, this indicates that young erythrocytes are less radiosensitive.

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Section: Discussionsupporting

confidence: 83%

Haemolysis in Patients with Chronic Lymphocytic Leukaemia during Extracorporeal Irradiation of the Blood

Andersen

Karle

Dige‐Petersen

1970

Scandinavian Journal of Haematology

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“…Tracer studies using "Fe and Wr-labelled erythrocytes in rather small series of uncomplicated CLL have shown reduced erythrocyte-iron turnolver indicating a reduced or possible insufficient erythropoiesis (reduced recovery rate) as well as a reduced erythrocyte survival (Boye Nielsen 1966, Frischauf et al 1968).…”

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confidence: 99%

Discussion

1971

Scandinavian Journal of Haematology

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Erythrocyte sequestration was studied in 24 patients with chronic lymphocytic leukaemia (CLL) by infusion of autologous 51Cr‐labelled erythrocytes followed by surface measurements at regular intervals over the spleen, liver, and heart. To obtain a comparable expression of the accumulation of activity in spleens of different sizes, the splenic surface activities were corrected. The correction factors were determined using fluid‐filled balloons (simulating spleens) with the same amount of activity. In 19 patients with CLL the splenic erythrocyte pool increased with increasing spleen weight (500–4, 300 g). Moreover, the erythrocyte sequestration in the spleen increased with increasing pool. The maintenance of a large erythrocyte pool makes increased demands upon the erythropoiesis, which is perhaps already insufficient, and an increased splenic erythrocyte sequestration contributes to reducing the number of circulating erythrocytes. Splenectomy is invariably followed by increasing haemoglobin level and an average 30% increase of erythrocyte survival (22–48%). In cases of CLL plus splenomegaly the indications for splenectomy appear to be fairly simple, but may be supported by the demonstration of a large splenic erythrocyte pool and a large splenic erythrocyte destruction. The studies support the likelihood of lymphocytic infiltration in the liver (increased accumulation of activity), a finding which seems of prognostic significance.

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Die chronische lymphatische Leukämie

Theml¹

1978

Blut Und Blutkrankheiten

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Erythrokinetische Untersuchungen mit59Fe und51Cr bei chronischen Lymphadenosen

Cited by 4 publications

References 7 publications

Haemolysis in Patients with Chronic Lymphocytic Leukaemia during Extracorporeal Irradiation of the Blood

Haemolysis in Patients with Chronic Lymphocytic Leukaemia during Extracorporeal Irradiation of the Blood

Discussion

Die chronische lymphatische Leukämie

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