Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3‐mediated regulation of actin filament assembly into the erythroblast membrane skeleton
Abstract:Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament (F‐actin) assembly and organization during terminal ED have revealed essential roles for the F‐actin pointed‐end capping proteins, tropomodulins (Tmod1 and Tmod3). Tmods bind tropomyosins (Tpms), which enhance Tmod capping and F‐actin stabilization. Tmods can also nucleate F‐actin assembly, independent of Tpms. Tmod1 is pre… Show more
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