Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia

Latour, Chloé; Wlodarczyk, Myriam F.; Jung, Grace; Gineste, Aurélie; Blanchard, Nicolas; Ganz, Tomas; Roth, Marie‐Paule; Coppin, Hélène; Kautz, Léon

doi:10.3324/haematol.2016.150227

Cited by 34 publications

(44 citation statements)

References 45 publications

(62 reference statements)

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“…This study raises questions about this new erythroid hormone and its role in hepcidin suppression in different types of anemia. [10][11][12][13] As there have been no previous reports on the relation between human serum erythroferrone and iron status parameters levels in cases with iron deficiency anemia; the present study aimed to demonstrate the relation between serum erythroferrone and iron status parameters levels in this widespread type of pediatric anemia.…”

Section: Discussionmentioning

confidence: 92%

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Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

Gendy

El-Hawy

Shehata

et al. 2018

European J of Haematology

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Serum erythroferrone levels in iron deficiency anemia patients (191.55 ± 83.74 pg/mL) were significantly higher than those in control group (42.22 ± 16.55 pg/mL) (P < .001). In iron deficiency anemia patients, serum erythroferrone concentrations correlated negatively with hemoglobin concentration (r = -.39; P = .01), serum iron (r = -.63; P < .001), transferrin saturation (r = -.66; P < .001), and serum ferritin (r = -.46; P = .004) while positive correlation was observed between serum erythroferrone concentrations and TIBC (r = .62; P < .001) CONCLUSION: The newly identified erythroferrone hormone may act as physiological hepcidin suppressor in cases with iron deficiency anemia, and so it may serve as a specific promising target of therapy in such cases.

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Section: Discussionmentioning

confidence: 92%

“…Erythroferrone is lately identified by Kautz et al as key regulator of iron homeostasis during stress erythropoiesis by suppressing hepcidin expression. This study raises questions about this new erythroid hormone and its role in hepcidin suppression in different types of anemia …”

Section: Discussionmentioning

confidence: 98%

Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

Gendy

El-Hawy

Shehata

et al. 2018

European J of Haematology

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“…Ciekawy przykład wpływu ERFE na przebieg choroby zaprezentowano w pracy dotyczącej malarii [23]. Jest to choroba pasożytnicza wywoływana przez zarodźce z rodzaju Plasmodium.…”

Section: Potencjalne Możliwości Zastosowania Erfeunclassified

“…Równocześnie w badaniach Latour i wsp. [23] stwierdzono, że w późnej fazie choroby istnieje ujemna zależność między stężeniem hepcydyny a wartością ERFE w szpiku kostnym i śledzionie zarażonych malarią myszy. Ponadto odnotowano, że 13. dnia od zainfekowania zwierzęta z niedoborem ERFE wykazywały znacznie niższą parazytemię niż myszy typu dzikiego.…”

Section: Potencjalne Możliwości Zastosowania Erfeunclassified

Erytroferron — nowy hormon regulujący syntezę hepcydyny

2018

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Żelazo jest metalem niezbędnym do życia, ale zarówno jego niedobór, jak i nadmiar prowadzi do poważnych zaburzeń funkcjonowania organizmu. W utrzymaniu ustrojowej homeostazy żelaza biorą udział różne białka. Wiele z nich już dokładnie opisano, a część weszła do puli powszechnie stosowanych parametrów służących ocenie gospodarki żelazem. W 2014 roku zidentyfikowano nowe białko, erytroferron, hamujące syntezę cząsteczki hepcydyny i jednocześnie zwiększające dostępność żelaza niezbędnego do procesu erytropoezy. Celem niniejszej pracy jest przedstawienie dotychczasowej wiedzy na temat budowy, funkcji oraz potencjalnego zastosowania erytroferronu.

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“…It is likely that increased erythroblasts in the dyserythropoietic bone marrow secrete a factor that inhibits hepcidin expression. In mice, erythroferrone (FAM132b), a tumor necrosis factor superfamily molecule, was shown to be expressed by erythroblasts and suppress hepcidin expression [54][55][56][57][58].…”

Section: Regulation Of Systemic Iron Homeostasis By Hepcidinmentioning

confidence: 99%

The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis

Kawabata

2017

Int J Hematol

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Hereditary hemochromatosis (HH) is a group of genetic iron overload disorders that manifest with various symptoms, including hepatic dysfunction, diabetes, and cardiomyopathy. Classic HH type 1, which is common in Caucasians, is caused by bi-allelic mutations of HFE. Severe types of HH are caused by either bi-allelic mutations of HFE2 that encodes hemojuvelin (type 2A) or HAMP that encodes hepcidin (type 2B). HH type 3, which is of intermediate severity, is caused by bi-allelic mutations of TFR2 that encodes transferrin receptor 2. Mutations of SLC40A1 that encodes ferroportin, the only cellular iron exporter, causes either HH type 4A (loss-of-function mutations) or HH type 4B (gain-of-function mutations). Studies on these gene products uncovered a part of the mechanisms of the systemic iron regulation; HFE, hemojuvelin, and TFR2 are involved in iron sensing and stimulating hepcidin expression, and hepcidin downregulates the expression of ferroportin of the target cells. Phlebotomy is the standard treatment for HH, and early initiation of the treatment is essential for preventing irreversible organ damage. However, because of the rarity and difficulty in making the genetic diagnosis, a large proportion of patients with non-HFE HH might have been undiagnosed; therefore, awareness of this disorder is important.

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Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia

Cited by 34 publications

References 45 publications

Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

Erytroferron — nowy hormon regulujący syntezę hepcydyny

The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis

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