Erythroderma, Hypogammaglobulinemia, and T-Cell Lymphocytosis

Lillie, Madeline A.

doi:10.1001/archderm.1983.01650290055017

Cited by 23 publications

(3 citation statements)

References 19 publications

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“…Phenytoin is recognized to cause selective IgA deficiency [46][47][48] and less commonly panhypogammaglobulinemia. [49][50][51][52][53][54][55] A number of these cases had other clinical features compatible with DHS. [52][53][54] Hypogammaglobulinemia is also reported with the use of carbamazepine, [56][57][58] phenobarbital, 59 and sodium valproate.…”

Section: Clinical and Laboratory Features Of Reported Cases Of Drug Hmentioning

confidence: 99%

Is a Drug Alone Sufficient to Cause the Drug Hypersensitivity Syndrome?

Wong¹,

Shear²

2004

Arch Dermatol

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Section: Clinical and Laboratory Features Of Reported Cases Of Drug Hmentioning

confidence: 99%

Is a Drug Alone Sufficient to Cause the Drug Hypersensitivity Syndrome?

Wong¹,

Shear²

2004

Arch Dermatol

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“…A reduced number of circulating T-lymphocytes (Fontana et al , 1978;Gilhus et al , 1982) or an impaired response to mitogen stimulation (Shakir et al, 1978), often associated with IgA deficiency (Horowitz & Hong, 1975;Gilhus et al , 1982) has been observed during phenytoin treatment. However, other reports indicate that during phenytoin administration the number of circulating T-lymphocytes is unchanged (Seager et al , 1975) or increased (Lillie et al , 1983). Unfortunately, many of the existing reports are often poorly comparable due to the difference in experimental designs and patient populations.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Anticonvulsant Monotherapy on Lymphocyte Subpopulations in Adult Epileptic Patients

et al. 1985

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Sixty-five patients undergoing long-term monotherapy for at least 3 months with phenytoin, carbamazepine or phenobarbital were screened for lymphocyte and immunoglobulin abnormalities. In 57% of patients the duration of therapy was longer than 12 months. The control subjects were matched for sex and age and none of them was taking drugs. The average serum immunoglobulin (IgG, IgA, IgM) values did not differ in control and patient groups. A significant decrease of OKT4+ cells was seen with all drugs, while other lymphocyte subpopulations were differently affected depending on the drug used. It is concluded that long-term single-drug treatment with phenytoin, carbamazepine and phenobarbital exhibits immunosuppressant effects through a complex action which involves more than one lymphocyte subpopulation. Moreover, the possible interference of the disease state with the immune functions of epileptic patients is discussed.

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“…Our patient had carcinoma of the prostate which indicates this. In addition, phenytoin is believed to cause dysfunction of T-suppressor cells [25], Possibly, this dysfunction could lead not only to the pro liferation of T lymphocytes but also to a monoclonal pro liferation of T-helper cells which characterize the Sezary syndrome. Our patient represents the first case of Sezary syndrome associated with phenytoin therapy with histo logical, immunological, EM, flow cytometric and molecu lar genetic confirmation.…”

mentioning

confidence: 99%