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Erythroderma with complicated etiology is one of the severe skin diseases and has high mortality, of which the incidence was 0.5‰-1.5‰ in skin diseases. Erythrodermic psoriasis (EP) is the commonest type of erythroderma. In addition, there are drug-induced erythroderma, erythroderma secondary to preexisting dermatoses, malignancy-related erythroderma, and idiopathic erythroderma of unknown etiology. Erythroderma of different etiologies has various clinical manifestations, resulting in relevant curative effects and outcomes. In this article, we retrospectively investigated 205 erythroderma patients about clinical symptoms, auxiliary examination and treatments, and evaluated the efficacy and prognosis. There were 84 cases of EP among 205 patients, 10 cases of erythroderma caused by specific drugs, 77 cases of erythroderma secondary to preexisting dermatoses (excluding psoriasis), 7 cases of erythroderma patients suffering from malignancy and 27 cases with unknown causes. We concluded that the etiology of male patients in different age groups had significant difference. The incidence of EP was the highest among all types. The EP was commonly accompanied with hypoproteinemia, and changed into psoriasis vulgaris after treatment. Drug-induced erythroderma was commonly accompanied with fever, and mostly cured by systematic steroid therapy. For erythroderma secondary to preexisting dermatoses, the original dermatoses must be actively treated to achieve a satisfying prognosis. Erythroderma with malignancy or unknown causes had long-term duration, poor response to the treatment, and high potential to relapse. Therefore, clarifying the etiology, providing an appropiate and individual regimen, and regular follow-up are crucial for the successful treatment of erythroderma with unknown causes.
Erythroderma with complicated etiology is one of the severe skin diseases and has high mortality, of which the incidence was 0.5‰-1.5‰ in skin diseases. Erythrodermic psoriasis (EP) is the commonest type of erythroderma. In addition, there are drug-induced erythroderma, erythroderma secondary to preexisting dermatoses, malignancy-related erythroderma, and idiopathic erythroderma of unknown etiology. Erythroderma of different etiologies has various clinical manifestations, resulting in relevant curative effects and outcomes. In this article, we retrospectively investigated 205 erythroderma patients about clinical symptoms, auxiliary examination and treatments, and evaluated the efficacy and prognosis. There were 84 cases of EP among 205 patients, 10 cases of erythroderma caused by specific drugs, 77 cases of erythroderma secondary to preexisting dermatoses (excluding psoriasis), 7 cases of erythroderma patients suffering from malignancy and 27 cases with unknown causes. We concluded that the etiology of male patients in different age groups had significant difference. The incidence of EP was the highest among all types. The EP was commonly accompanied with hypoproteinemia, and changed into psoriasis vulgaris after treatment. Drug-induced erythroderma was commonly accompanied with fever, and mostly cured by systematic steroid therapy. For erythroderma secondary to preexisting dermatoses, the original dermatoses must be actively treated to achieve a satisfying prognosis. Erythroderma with malignancy or unknown causes had long-term duration, poor response to the treatment, and high potential to relapse. Therefore, clarifying the etiology, providing an appropiate and individual regimen, and regular follow-up are crucial for the successful treatment of erythroderma with unknown causes.
Background: Erythroderma or exfoliative dermatitis is an inflammatory disorder characterized by erythema and scaling in the body involving more than 90% of the body surface. Underlying etiologies which lead to erythroderma are commonly psoriasis (23%), spongiotic dermatitis (16%), drug hypersensitivity reactions (15%) and cutaneous T cell lymphoma (16%). Aims: The aim of our study was to find out the histopathologically erythroderma cases and to evaluate the clinicopathological correlation of such cases. Methods: Skin biopsies of 60 erythroderma cases were received in the department of Pathology. The samples were processed, stained and examined under light microscope. Results: Erythroderma was more common in males (60%) with male to female ratio 1.5:1. Mean age of incidence was 43.3 years. Majority of the cases were acute in onset (51.67%) with shortest duration of 5 days. Pre-existing dermatoses was responsible in 68.33% cases with maximum cases being psoriasis in 33.33% and eczema in 31.67%. Drug induced erythroderma was seen in 16.67% cases. Winter was the aggravating season in 48.14% patients especially in psoriasis. Systemic features such as fever, tachycardia, etc were reported in 76.67% cases. Scales were seen in 83.33% cases and nail changes in 68.33%. Out of 60 cases, 49 cases (81.67%) had positive clinicopathological correlation with best correlation seen in psoriatic erythroderma. P value is<0.001 with strong clinical significance. Conclusion: Erythroderma has many overlapping features which made the identification of underlying disease quiet challenging sometimes. Therefore thorough clinical examination and patients' detailed history along with microscopic findings is essential to rule out all the differential diagnosis.
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