Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma

Hanafusa, Takaaki; Igawa, Ken; Takagawa, Shinsuke; Yahara, H.; Harada, Jun; Tani, Mizuki; Sawada, Yasuyuki; Katayama, Ichiro

doi:10.1111/j.1468-3083.2011.04150.x

Cited by 8 publications

(18 citation statements)

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“…Paraneoplastic erythroderma has been previously reported in the literature, and is most commonly associated with lymphomas 1 , 3 . It has also been reported in cases of myelodysplasia as well as in solid tumors of various organs including the lungs, colon, and cervix 3 , 4 . These skin changes can precede clinical malignancy by several years 4 .…”

Section: Discussionmentioning

confidence: 98%

Hypersensitivity Reaction as a Harbinger of Acute Myeloid Leukemia: A Case Report and Review of the Literature

et al. 2015

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Cutaneous paraneoplastic syndromes comprise a broad spectrum of cutaneous reactions to an underlying malignancy. These dermatoses are not the result of metastatic spread to the skin, but rather a reaction to the presence of malignancy. Cutaneous paraneoplastic syndromes often precede the identification of a malignancy. We describe the case of a 79-year-old man with a six-month history of recalcitrant treatment- resistant dermatitis. A complete blood count test performed at the time of initial presentation was normal. The patient ultimately presented with erythroderma and was diagnosed with acute myeloid leukemia (AML). The evolution of the dermatitis to erythroderma coincided with the clinical presentation of AML, and was therefore considered to be a paraneoplastic syndrome. The patient decided against therapy and died seven weeks after diagnosis. Physicians should consider a cutaneous paraneoplastic syndrome when faced with dynamic recalcitrant dermatoses that are difficult to treat and decide on laboratory testing accordingly. Patients should be evaluated regularly for two to three years after initial diagnosis with a physical exam and review of systems to monitor for signs and symptoms of malignancy.

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Section: Discussionmentioning

confidence: 98%

Hypersensitivity Reaction as a Harbinger of Acute Myeloid Leukemia: A Case Report and Review of the Literature

et al. 2015

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“…Therefore, familiarity with disease presentation is critical for early appropriate diagnosis and management [ 40 , 41 ]. Skin manifestations of secondary cutaneous ALCL may also arise as paraneoplastic processes, with cases of acquired ichthyosis [ 42 ] and erythroderma [ 43 ] documented in the literature.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Lymphoma Kinase in Cutaneous Malignancies

Cao

Nambudiri

2017

Cancers

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Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma. The characterization of ALK-positivity in these cutaneous malignancies presents exciting opportunities for utilizing ALK-targeted inhibitors in the treatment of these diseases.

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“…Extensive literature search identified 4 cases of ALTCL-associated paraneoplastic dermatoses [ 5 , 6 , 7 ]. The average age of patients was 42.8 ± 23 years (range 23-71).…”

Section: Discussionmentioning

confidence: 99%

“…The degree of skin involvement varied between cases, either affecting the entire body or more focal areas such as the face, hands, or feet. Two cases were mild, presenting with diffuse erythema and a dry skin rash [ 5 , 6 ]. One case presented with multiple punched-out, ulcerative lesions in his lower extremities that responded well to systemic chemotherapy [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Paraneoplastic conditions most commonly cause endocrine abnormalities; however, a large percentage present with skin findings [ 4 ]. Anaplastic large T-cell lymphoma (ALTCL) has only rarely been associated with dermatoses including diffuse erythroderma [ 5 ], skin ulceration [ 6 ], and pemphigus [ 7 ]. Skin manifestations of ALTCL are mostly the result of secondary metastasis.…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review

et al. 2016

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Background/Aims: Paraneoplastic dermatoses are skin disorders that are associated with malignancy. Anaplastic large T-cell lymphoma (ALTCL) has rarely been associated with paraneoplastic skin manifestations such as gangrenous foot ulcers and erythroderma. Methods: We describe a case of ALTCL presenting as a large annular skin rash. The clinical picture, course, and treatment will be discussed along with current hypotheses on the mechanism of paraneoplastic syndromes. Results: Skin manifestations in ALTCL most commonly arise in two distinct ways; either as primary cutaneous lymphoma manifestation or as systemic disease with secondary metastasis. Less commonly, systemic disease causes skin manifestations secondary to a paraneoplastic process without infiltration of malignant cells. This is thought to be mediated by an immunologic reaction to tumor antigen or the result of cytokines and other inflammatory markers produced by the tumor itself. Conclusion: Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.

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Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma

Abstract: s-ALCL development may be predicted by the precedence and concurrence of intractable paraneoplastic erythrodermic and ulcerative skin lesions, as reported in our two cases.

Cited by 8 publications

References 9 publications

Hypersensitivity Reaction as a Harbinger of Acute Myeloid Leukemia: A Case Report and Review of the Literature

Hypersensitivity Reaction as a Harbinger of Acute Myeloid Leukemia: A Case Report and Review of the Literature

Anaplastic Lymphoma Kinase in Cutaneous Malignancies

Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review

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