Erythrocyte δ -aminolevulinic Acid Dehydratase in New Lead Exposure

Hernberg, Sven; Tola, S; Nikkanen, J.; Valkonen, Sinikka

doi:10.1080/00039896.1972.10666145

Cited by 44 publications

(15 citation statements)

References 4 publications

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“…There was an excellent intraindividual correlation between ALAD activity and PbB in our study, far better than has been 182 reported for groups of individuals (11,12,13,16,25,34) for whom interindividual variations influenced the results. There has been some discussion on whether a threshold PbB exists with regard to impact on ALAD activity.…”

Section: Ala In Urine Coproporphyrin In Urinecontrasting

confidence: 46%

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Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Schütz¹,

Skerfving²

1976

Scand J Work Environ Health

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Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects. by Schütz A, Skerfving S Key terms: blood; blood lead; blood lead level; coproporphyrin; dehydratase activity; delta-aminolevulinic acid; delta-aminolevulinic acid coproporphyrin; delta-aminolevulinic acid dehydratase activity; erythrocyte; excretion; experimental exposure; exposure; follow up; half-time; heavy exposure; lead; lead dust; male subject; man; short exposure; urinary excretion; urine This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/788149 Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte c5 -'aminolevulinic acid dehydratase activity and urinary excretion of lead, c5 -aminolevulinic acid and coproporphyrin Results of a 6-month follow-up of two male subjects! by ANDREJS SCHUTZ, B.Sc., and STAFFAN SKERFVING, M.D.2 SCHaTZ, A. and SKE'RFVING, S. Effect of a short heavy exposure to lead dust upon blood lead level, erythrocyte o-aminolevulinic acid dehydratase activity and urinary excretion of lead, o-aminolevulink acid and coproporphyrin: Results of a 6-month follow-up of two marre subjects. Scand. j. work environ. & heaLth 3 (1976) 176-184. During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/l and minimum blood cell o-aminolevulinic acid dehydratase activities (ALAD) (6 Ofo of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/l. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/l.

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Section: Ala In Urine Coproporphyrin In Urinecontrasting

confidence: 46%

“…We found a dramatic decrease in ALAD activity in the RBC already within 14 h after the short heavy exposure, Le., earlier by days than the decrease reported in workers at the onset of lead exposure (16,35). It is reasonable to assume that ALAD activity decreased already during the exposure as PbB rose.…”

Section: Ala In Urine Coproporphyrin In Urinementioning

confidence: 39%

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Schütz¹,

Skerfving²

1976

Scand J Work Environ Health

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“…Many investigators (Hernberg and Nikkanen 1970;Hernberg et al 1972;Tola et al 1973;Tomokuni and Ogata 1976) have reported that the degree of inhibition of erythrocyte ALA-D activity has a close correlation with the concentration of lead in blood and that its partial inhibition occurs long before any other biological effect are measurable, in the persons exposed to lead. On the other hand, more recently, Buc and Kaplan (1978) have demonstrated that the erythrocyte Py5N activity is decreased, even when most of the other biological tests of lead intoxication remains negative and that, therefore, the erythrocyte Py5N is a convenient, reliable and sensitive index of lead exposure.…”

Section: Discussionmentioning

confidence: 98%

Comparative study of effects of lead on the activity of erythrocyte pyrimidine 5′-nucleotidase and delta-aminolevulinate dehydratase in vivo and in vitro

Tomokuni

Ogata

1980

Arch Toxicol

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The effect of lead on the activities of erythrocyte pyrimidine 5'-nucleotidase (Py5N) and delta-aminolevulinate dehydratase (ALA-D) was studied in the mice which were given ad libitum a drinking water containing lead of 10, 50 and 250 ppm, for 27 days. The erythrocyte Py5N activity was not decreased in all groups of lead-exposed mice. However, the erythrocyte ALA-D activity was markedly decreased in the groups exposed to 50 and 250 ppm lead. These data indicate that erythrocyte ALA-D is more sensitive than Py5N to lead in vivo. On the other hand, from the in vitro study, it was demonstrated that the human erythrocyte Py5N is moderately inhibited by zinc and tin, and markedly by mercury, cadmium, silver, copper, and lead, at 10(-4) molar concentrations. In addition, it was observed that the erythrocyte Py5N is most remarkably inhibited by mercury while the ALA-D by lead, among metals tested.

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“…This effect was further supported hy the multiple regression analysis, The latter calculation also displayed an effect of lead, which on a molar basis was of about the same strength as that of mercury, Wada et al (36) reported a negative correIation between mercury levels in urine and hlood cell ALA-D activity in workers exposed to elemental mercury vapor, They did, however, not report the blood lead levels, and the result is thus difficult to interpret. Hernherg et al (17) and Lauwerys and Buchet (21) …”

Section: Discussionmentioning

confidence: 99%

“…4,2.1.24) (5,15,16,17,18), an enzyme engaged in the heme synthesis. The sulfhydryl groups in ALA-D are necessary for enzymatic activity (14).…”

Section: Methodsmentioning

confidence: 99%

Blood cell delta-aminolevulinic acid dehydratase activity in humans exposed to methylmercury.

Schütz¹,

Skerfving²

1975

Scand J Work Environ Health

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Erythrocyte δ -aminolevulinic Acid Dehydratase in New Lead Exposure

Cited by 44 publications

References 4 publications

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Comparative study of effects of lead on the activity of erythrocyte pyrimidine 5′-nucleotidase and delta-aminolevulinate dehydratase in vivo and in vitro

Blood cell delta-aminolevulinic acid dehydratase activity in humans exposed to methylmercury.

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