Erythrocyte Volume end Body Composition in Oxymetho Lone-Treated Hypophysectomized Rats

Abstract

Short Communicationsare reported (Herold, Hurvitz and Tadmor 1971). HGH positively influenced the chondrogenesis in 6 patients with delayed union and pseudarthroses (Mühlbach and Hirthe 1967). This investigation has been effected in co-operation with a research team concerned with HGH in the treatment of delayed union and pseudarthroses of bone (Koskinen, Lindholm, Nieminen, Puranen and Attila 1975). For reasons of species specifity optimal response was expected. Material and methoclsTwelve patients with fresh fractures of the lower leg were treated with HGH (Crescormon, Kabi Ab) 16 I.U. i.m. every second day during five weeks in addition to orthopaedic treatment Serum calcium, phosphorus, hydroxyproline, alkaline phospbatase and HGH content plus excretion rates of calcium, phosphorus and hydroxyproline were determined at 0,1,3 and 5 weeks after injury.The progress of healing was interpreted by clinical and radiological evidence. ReSlllts and conclusionsBony union ensued in eleven of twelve patients. The time required for consolidation to take place was 8-12 weeks in 7 patients, 13-16 weeks in 4 patients and more than 16 weeks in one patient.In the control group of eight patients the time required for consolidation was 8-12 weeks in one patient, 13-16 weeks in 6 patients and more than 16 weeks in one patient. In both groups one patient bad to undergo operative treatment for de-Iayed union of the fracture.