Erythrocyte Sedimentation Rate Predicts Early Relapse and Survival in Early-Stage Hodgkin Disease

Henry-Amar, Michel; Friedman, Samuel; Hayat, M.; Somers, R.; Meerwaldt, Jokobus H.; Carde, Patrice; Burgers, J. M. V.; Thomas, José; Monconduit, M.; Noordijk, Evert M.; Bron, Dominique; Regnier, R; Pauw, B.E. de; Tanguy, Alain; Cosset, Jean‐Marc; Dupouy, N.; Tubiana, M

doi:10.7326/0003-4819-114-5-361

Cited by 91 publications

(35 citation statements)

References 10 publications

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“…The inflammation score predicts both cancer and cardiovascular disease mortality (Godsland et al, 2011). In cancer, ESR has only been studied as a predictor of progression (Henry-Amar et al, 1991;Borre et al, 1997). Bear et al reported that elevated C-reactive protein (CRP) levels were related to poor prognosis in patients with metastatic prostate cancer (Beer et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak

Zengın²,

Tanık³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak

Zengın²,

Tanık³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…10 An elevated ESR is also associated with Hodgkin's disease and an elevated ESR after chemotherapy for Hodgkin's disease has been found to be a poor predictor of survival. 11 Patients with collagen vascular diseases, significant infection, or malignancy almost always have symptoms or signs that suggest a more involved or complicated disorder than what is expected in an individual with usual atopy. It is at this point that an ESR, in conjunction with other laboratory tests, may be helpful in supporting a mimicking or complicating disorder.…”

Section: Esr In Allergy/immunologymentioning

confidence: 95%

Uses of Erythrocyte Sedimentation Rate in Allergy/Immunology

Reichmuth¹,

Ledford²

2002

Pediatric Asthma, Allergy & Immunology

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The erythrocyte sedimentation rate (ESR), one of the original tests of modern medicine, is a relatively simple procedure that continues to be used in evaluating medical conditions. Its function in the allergist/clinical immunologist's practice is to assess patients with an unusual presentation of a normally encountered condition for an underlying disorder, e.g., a severe asthmatic with Churg Strauss syndrome. It is also used to identify potential etiologies of some disorders, such as vasculitis causing chronic urticaria. It is neither completely sensitive nor specific for diagnosing any disorder; thus, it is adjunctive to the history, physical exam, and other laboratory and radiological studies. The ESR does not have a role in assessing uncomplicated atopic conditions. (Pediatr Asthma Allergy Immunol 2002; 15[3]: 167-171.) METHODOLOGY T HE NATIONAL COMMITTEE FOR CLINICAL LABORATORY STANDARDS recommends the Westergren methodas the standard to determine the ESR. 1 This technique has not significantly changed over the last 70 years. 2 Four milliliters of whole blood is mixed with 1.0 mL of sodium citrate. This mixture is added to a Westergren tube, a vertical 2.5-mm diameter tube that is 30-cm long with the top 20 cm calibrated from 0 to 200 mm. The tube is filled to the zero mark at room temperature. At 60 minutes the upper level of the settled red blood cells (RBCs) is measured in millimeters from the zero mark. This value, in millimeters per hour, is the erythrocyte sedimentation rate (ESR). The modified Westergren method uses the same technique, but ethylenediaminetetraacetic acid (EDTA) is used as an anticoagulant to permit assaying other hematologic tests with the same sample. A micro-ESR method useful in newborns utilizes a similar technique but only requires 0.2 mL of blood. 1 The normal Westergren ESR is 0-2 mm/hr in a newborn, 0-10 mm/hr in a child, 0-15 mm/hr in a female adult, and 0-10 mm/hr in a male adult. 3 The ESR normally increases with age. For men, normal results are less than 30-40 mm/hr for ages older than 85 years and 30 mm/hr or less for ages 50-85 years. Similarly, for normal women, results are 42 mm/hr or less for ages older than 85 years and 30 mm/hr or less for ages 50-85 years. 1,4 A rule of thumb for the normal ESR in men is age in years divided by 2, and in women, age in years, divided by 2 plus 5-10.

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“…Elevated ESR is a prognostic factor in Hodgkin's disease [43][44][45]. In one study, it has shown significance in univariate analysis for survival in patients with primary gastrointestinal NHL [46].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Large Cell Lymphomas: Identification of Prognostic Factors and Validation of the International Non-Hodgkin’s Lymphoma Prognostic Index

Nicolaides

Fountzilas

Zoumbos³

et al. 1998

Oncology

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Several clinical prognostic factors have been identified that predict treatment outcome in patients with diffuse large cell lymphomas. An International Non-Hodgkin’s Lymphoma Prognostic Index (IPI) has been recently formulated. We tried to identify the clinical prognostic factors that predict treatment outcome in Greek patients with diffuse large cell lymphomas and validated the IPI in these patients. The possible prognostic variables for tumor response, relapse-free (RFS) and overall survival (OS) were analyzed in 239 consecutive patients treated with anthracycline-based chemotherapy regimens. In univariate analysis, factors associated with poor response were stages III–IV, performance status (PS) ≥2, spleen and bone marrow involvement, more than one extranodal site involved, increased lactate dehydrogenase (LDH) value, hemoglobin (Hb) <12 g/dl, albumin <3.5 g/dl, erythrocyte sedimentation rate (ESR) >50 mm/h. Multivariate analysis identified stage, PS, more than one extranodal site involved, increased LDH level, and ESR > 50 mm/h as the factors more predictive of poor response. For RFS, multiple Cox analysis found stages III–IV and bone marrow involvement to be statistically significant. For OS, multiple Cox analysis identified stage III–IV, PS ≥2, bone marrow involvement, more than one extranodal site involved, increased LDH level and ESR > 50 mm/h as negative prognostic factors. Patients stratified in the different risk groups of the IPI had a significantly different outcome regarding complete response (CR) rate, RFS and OS. In conclusion, although age >60 years was not recognized as an adverse factor in this analysis, our patients stratified in the different groups of the IPI had significant differences in CR rate, 2-year RFS and OS verifying the prognostic significance of the index. Bone marrow involvement and ESR > 50 mm/h, parameters that are not included in the IPI, adversely affected survival.

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Erythrocyte Sedimentation Rate Predicts Early Relapse and Survival in Early-Stage Hodgkin Disease

Cited by 91 publications

References 10 publications

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Uses of Erythrocyte Sedimentation Rate in Allergy/Immunology

Diffuse Large Cell Lymphomas: Identification of Prognostic Factors and Validation of the International Non-Hodgkin’s Lymphoma Prognostic Index

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