Erythrocyte sedimentation rate measured using microhemagglutination is not elevated in monoclonal gammopathy compared with other diseases

Kim, M.; Ju, Young‐Su; Lee, E. J.; Lee, E.; Jeon, Kibum; Lee, J.; Kang, Hee Jung; Kim, H.-S.; Lee, J.-S.; Kim, H. J.; Lee, Y. K.

doi:10.1111/ijlh.12859

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…[5] Measurement method for ESR in Celltac α+ (MEK 1305) [5] In the ESR measuring unit, light from an LED is emitted onto the agitated blood, and the light that passes through is continuously measured by a light-receiving element The above method comparison obtained in the present study is comparable with selected 16 similar published studies evaluating performance of various alternate/modified Westergren methods for ESR determination against reference Westergren method [Table 3]. [10][11][12][13][14][15][16][17][18][19][20][21][22][23] Intrarun precision results obtained by analyzing nine patient samples in 11 replicates yielded coefficient of variation (CV) % ranging to 0-14% which is comparable with similar studies [Table 4].…”

Section: Discussionsupporting

confidence: 58%

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Comparison of alternate erythrocyte sedimentation rate measurement by automated Celltac α+ (MEK 1305) and reference Westergren method

Kahar¹

2022

JHAS

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Objectives: Manual Westergren method is routinely used for ESR measurement; however, it has many limiting factors which include inherent and technical factors. Alternate/modified Westergren methods have been devised to overcome the limitations of the manual Westergren method. These new methods must be properly evaluated before introducing in clinical laboratories. Material and Methods: A total of 350 randomly collected Ethylene Diamine Tetraacetic Acid (EDTA) samples from hospitalized and ambulatory patients were assayed parallelly in the recently launched Hematology Analyzer Celltac α+ (MEK 1305) and manual Westergren method. Results of these assays were subjected to statistical analysis using a coefficient of correlation, Passing-Bablok regression, and the Bland-Altman statistical methods and the results of the present study were also compared with 16 selected similar studies published in the past 22 years. Intrarun precision using patient samples and inter-run precision using manufacturer’s controls (MEK-3DN and MEK-3DL) were also determined. Results: The present study revealed a Pearson correlation of 0.9058, mean bias of −6.43, and limits of agreements 17.5–−30.4, between Celltac α+ (MEK 1305) and the reference Westergren method. Intrarun precision using patient samples yielded a coefficient of variation ranging from 0% to 14% and inter-run precision using commercial controls yielded a CV of 9.32% for abnormal (MEK-3DL) control and 13.6% for normal level control (MEK-3DN). Conclusion: With good correlation between Celltac α+ (MEK 1305) and the reference Westergren method, acceptable bias, and limits of agreements, automated Celltac α+ (MEK 1305) with its additional advantages is a valid substitute for the reference ESR method in clinical laboratories.

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Section: Discussionsupporting

confidence: 58%

“…14. Kim et al [21] 2018 published by Mahlangu and Davids, [14] Horsti et al, [17] and Schapkaitz et al [20] Celltac α+ (MEK 1305) being an automated closed system offers many advantages such as ease of performance, safety, savings on consumables, use of EDTA…”

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confidence: 99%

Comparison of alternate erythrocyte sedimentation rate measurement by automated Celltac α+ (MEK 1305) and reference Westergren method

Kahar¹

2022

JHAS

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“…In chronic inflammatory diseases, ESR may be elevated despite a low or normal CRP owing to its immune mechanism 26‐28 . A primary screening test to predict chronic inflammatory disease would be useful as there is little opportunity to get other information for inflammation in patients with a negative CRP 29 .…”

Section: Discussionmentioning

confidence: 99%

Accuracy study of a novel alternate method measuring erythrocyte sedimentation rate for prototype hematology analyzer Celltac α+

Maki

Tabe

Yamamoto

et al. 2021

Int J Lab Hematology

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Introduction The erythrocyte sedimentation rate (ESR) is a nonspecific inflammation indicator. In laboratory testing, automated ESR analyzers may use the reference Westergren method (Reference WG), modified Westergren (Modified WG), or Alternate ESR method (Alternate ESR) based on photometric rheology. A prototype hematology analyzer Celltac α+ (Nihon Kohden Corporation) with built‐in Novel ESR analysis technology (Novel ESR) was developed to improve the accuracy of Alternate ESR. Alternate ESR uses only the aggregation phase information of Reference WG. The Novel ESR adds sedimentation and packing phase information obtained by hematology analyzer measurands. High correlation with WG was ensured by predicting the ESR value using Hematocrit (Hct) and MCV values as correcting parameters. Methods Novel ESR was compared with Modified WG (MONITOR‐40, Joko Corporation) and Reference WG, according to internationally recognized guidelines: Precision, carryover, limit of quantification, comparability, linearity, accuracy, and fibrinogen sensitivity. Samples from healthy volunteers and clinical patients were used. The correction performance of Novel ESR and Modified WG was compared with Reference WG by regression analysis in three range categories for ESR and measurands affecting ESR correction (Hct, MCV, and MCH). Results Novel ESR showed sufficient basic performance and comparability with Modified WG. In the accuracy study comparing with Reference WG, the regression equation was y = 1.026x + 0.5(r = .945,P < .001;n = 271). When evaluating the correction performance, the slopes were within 0.8‐1.2, except for the high part of Hct. All intercepts were within 10 mm. Conclusion This study validated the correction performance to the initial estimated ESR value by aggregation phase information using information reflecting sedimentation and packing phase obtained from automated hematology analyzer. The Celltac α+ Novel ESR provided results equivalent to Reference WG.

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Human serum paraben levels and their associations with rheumatoid arthritis: a case-control study from Hangzhou, China

Zhao

et al. 2022

Environ Sci Pollut Res

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Erythrocyte sedimentation rate measured using microhemagglutination is not elevated in monoclonal gammopathy compared with other diseases

Cited by 4 publications

References 24 publications

Comparison of alternate erythrocyte sedimentation rate measurement by automated Celltac α+ (MEK 1305) and reference Westergren method

Comparison of alternate erythrocyte sedimentation rate measurement by automated Celltac α+ (MEK 1305) and reference Westergren method

Accuracy study of a novel alternate method measuring erythrocyte sedimentation rate for prototype hematology analyzer Celltac α+

Human serum paraben levels and their associations with rheumatoid arthritis: a case-control study from Hangzhou, China

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