Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type

Loomes, L. M.; Uemura, Keiichi; Childs, Robert A.; Paulson, James C.; Rogers, Gary N.; Scudder, Peter; Michalski, Jean‐Claude; Hounsell, Elizabeth F.; Taylor‐Robinson, David; Feizi, Ten

doi:10.1038/307560a0

Cited by 187 publications

(81 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…36 In contrast, IGHV4-34 antibodies are secreted at a high level in patients with systemic lupus erythematosus and in response to acute infections with herpes viruses and M. pneumoniae. [37][38][39][40][41] It has, therefore, been proposed that IGHV4-34 B cells may normally be maintained in a state of diminished responsiveness, sparing the host from potential (auto)immune-mediated pathologies. In line with this, most CLL clonotypic IGHV4-34 rearrangements are mutated, indicating that these CLL cells do not behave in an inherently different way from non-CLL IGHV4-34 B cells.…”

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 99%

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

Marincevic¹,

Mansouri²,

Kanduri³

et al. 2010

Haematologica

View full text Add to dashboard Cite

The online version of this article has a Supplementary Appendix. BackgroundNumerous subsets of patients with chronic lymphocytic leukemia display similar immunoglobulin gene usage with almost identical complementarity determining region 3 sequences. Among IGHV4-34 cases, two such subsets with "stereotyped" B-cell receptors were recently identified, i.e. subset #4 (IGHV4-34/IGKV2-30) and subset #16 (IGHV4-34/IGKV3-20). Subset #4 patients appear to share biological and clinical features, e.g. young age at diagnosis and indolent disease, whereas little is known about subset #16 at a clinical level. Design and MethodsWe investigated the global gene expression pattern in sorted chronic lymphocytic leukemia cells from 25 subset/non-subset IGHV4-34 patients using Affymetrix gene expression arrays. ResultsAlthough generally few differences were found when comparing subset to non-subset 4/16 IGHV4-34 cases, distinct gene expression profiles were revealed for subset #4 versus subset #16. The differentially expressed genes, predominantly with lower expression in subset #4 patients, are involved in important cell regulatory pathways including cell-cycle control, proliferation and immune response, which may partly explain the low-proliferative disease observed in subset #4 patients. ConclusionsOur novel data demonstrate distinct gene expression profiles among patients with stereotyped IGHV4-34 B-cell receptors, providing further evidence for biological differences in the pathogenesis of these subsets and underscoring the functional relevance of subset assignment based on B-cell receptor sequence features.Key words: stereotyped BCR, IGHV4-34, chronic lymphocytic leukemia, gene expression. IGHV4-34 B-cell receptors. Haematologica 2010;95(12):2072-2079. doi:10.3324/haematol.2010 This is an open-access paper. © F e r r a t a S t o r t i F o u n d a t i o n Citation: Marincevic M, Mansouri M, Kanduri M, Isaksson A, Göransson H, Smedby KE, Jurlander J, Juliusson G, Davi F, Stamatopoulos K, and Rosenquist R. Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

show abstract

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 99%

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

Marincevic¹,

Mansouri²,

Kanduri³

et al. 2010

Haematologica

View full text Add to dashboard Cite

show abstract

“…In these infections, 9G4 antibodies are responsible for the presence of pathogenic CA that mediate autoimmune hemolytic anemia [72]. Interestingly, while the fetal RBC linear NAL i-antigen is the usual target of CA in EBV infections, the branched NAL I-antigen expressed by adult RBC is overwhelmingly preferred by CA antibodies induced by M. pneumoniae [73]. We are thus presented with a fascinating scenario in which different infectious agents break, at least temporarily, B cell tolerance preferentially targeting autoreactive 9G4 B cells, yet resulting in the production of either anti-i or anti-I autoantibodies in a mutually exclusive fashion.…”

Section: G4 Antibodies In Health and Diseasementioning

confidence: 99%

Human innate B cells: a link between host defense and autoimmunity?

Milner

Anolik

Cappione

et al. 2005

Springer Semin Immun

View full text Add to dashboard Cite

B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.

show abstract

“…Sulphated glycolipids, dextran sulphate, NeuAcAE2-3Galâ1-4Glc Krivan et al (1989); Loomes et al (1984) …”

Section: Speciesmentioning

confidence: 99%

Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens

Thomas

Brooks

2004

Journal of Medical Microbiology

View full text Add to dashboard Cite

Intervention in bacterial adhesion to host cells is a novel method of overcoming current problems associated with antibiotic resistance. Antibiotic-resistant strains of bacteria that cause respiratory tract infections are a problem in hospitals and could be used in bioterrorist attacks. A range of bacterial species was demonstrated to attach to an alveolar epithelial (A549) cell line. In all cases, cell surface oligosaccharides were important in attachment, demonstrated by reduced adhesion when A549 cells were pre-treated with tunicamycin. Bacillus anthracis and Yersinia pestis displayed a restricted tropism for oligosaccharides compared to the environmental, opportunistic pathogens, Pseudomonas aeruginosa, Burkholderia cenocepacia, Burkholderia pseudomallei and Legionella pneumophila. The compound with the greatest anti-adhesion activity was p-nitrophenol. Other generic attachment inhibitors included the polymeric saccharides (dextran and heparin), GalNAcâ1-4Gal, GalNAcâ1-3Gal, Galâ1-4GlcNAc and Galâ1-3GlcNAc. Burkholderia pseudomallei attachment was particularly susceptible to oligosaccharide inhibition. Combinations of such compounds may serve as a novel generic therapeutics for respiratory tract infections. INTRODUCTIONThe development of antibiotic resistance amongst pathogenic bacteria is a frequent occurrence and of great concern for public health. This problem is associated with many bacteria that cause community-and hospital-acquired pneumonia such as Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa and Burkholderia cenocepacia (Lister, 2000;Lynch, 2001;Spencer, 1995;Tan, 2003). Problems with antibiotic resistance can also extend to those bacteria that could be used in bioterrorism. It is likely that such bacterial threat agents would be delivered by the aerosol route resulting in respiratory presentation of the disease (Cieslak & Eitzen, 2000;Leggiadro, 2000). Given the ease of natural acquisition of antibiotic resistance genes and genetic manipulation, it is prudent to research therapeutic alternatives to antibiotics.Attachment to cell surfaces is one of the key steps in bacterial pathogenesis, often involving oligosaccharides located on the host cell surface and bacterial adhesins (Karlsson et al., 1992;Ofek & Sharon, 1990). The terminal di-or trisaccharide units of these oligosaccharides may be used to inhibit these interactions, preventing attachment and hence disease (Zopf & Roth, 1996). The theory has been proven in vitro with a range of bacterial species. For example, lacto-N-neotetraose and asialoganglioside-GM1 (asialo-GM1) inhibit attachment of S. pneumoniae to alveolar epithelial cells (Tong et al., 1999). Similarly 3-sialyllactose inhibits Helicobacter pylori attachment to gastric epithelial cells . Asialoganglioside-GM1 and -GM2 are used as receptors by a number of respiratory pathogens, which specifically bind their terminal GalNAcâ1-3Gal and GalNAcâ1-4Gal moieties (Krivan et al., 1988a(Krivan et al., , b, 1991. The principle has also been proven to be valid in vivo...

show abstract

Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type

Cited by 187 publications

References 42 publications

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

Human innate B cells: a link between host defense and autoimmunity?

Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens

Contact Info

Product

Resources

About