Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Htoo, Mark S. H.; Kofkoff, Richard L.; Freedman, Michael L.

doi:10.1111/j.1532-5415.1979.tb01250.x

Cited by 40 publications

(15 citation statements)

References 9 publications

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“…The BM cytology, includ ing EM/ratio and differential count, were within the normal range for adults (table II), showing similar figures to those previously reported in aged persons (12,21,23]. Low hemoglobin values in old age have been pre viously reported [9,11]. Iron deficiency is common in healthy elderly people [10,14], and since the BM hemosiderin content in the BM was found to be low, it clearly points to iron deficiency as the main cause of the mild anemia observed in our group.…”

Section: Discussionsupporting

confidence: 77%

Granulopoiesis in Aged People: Inverse Correlation between Bone Marrow Cellularity and Myeloid Progenitor Cell Numbers

et al. 1987

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Results of a study on bone marrow (BM) cytology and cellularity, BM granulo-cytic-macrophage colony formation (GM-CFU-C), peripheral blood (PB) colony stimulating factor (CSF) and serum lysozyme activity in 20 elderly people aged from 64 to 89 are presented. Besides slight iron deficiency anemia, no hematological abnormality was detected. No change in PB and BM differential counts was found as compared to those obtained for normal adults. The BM cellularity and colony incidence were assessed using aliquots of the same specimen. GM-CFU-C frequency ranged from 15 to 156 (average 67.5) per 2 × 10⁵ BM cells seeded. The largest number of colonies was observed in hypocellular BM samples (p < 0.002). The level of serum lysozyme activity for the entire group was significantly higher than that obtained in healthy persons up to the age of 60 (p < 0.001). The overall results support the notion that in old age, increased proliferation of committed granulopoietic stem cells in hypoplastic areas of the BM, assure normal numbers of mature blood cells in the periphery.

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Section: Discussionsupporting

confidence: 77%

Granulopoiesis in Aged People: Inverse Correlation between Bone Marrow Cellularity and Myeloid Progenitor Cell Numbers

et al. 1987

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“…This suggests that falling haemoglobin levels may be a normal physiological response to aging, the so called 'anaemia of senescence'. In contrast, other studies have demonstrated a high incidence of anaemia in elderly indi viduals, associated with treatable causes (Htoo et al 1979;Milne & Williamson 1972).…”

Section: Normal Haemoglobin Levels In Elderly Patientsmentioning

confidence: 84%

Identification and Treatment of Anaemia in Older Patients

Murphy

Hutchinson

1994

Drugs & Aging

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Anaemia in elderly patients should never be regarded as a normal physiological response to aging. Underlying causes must be investigated and treated in a similar manner to that used in younger adults. In addition to a thorough history and physical examination, basic investigations such as red cell indices and morphology, reticulocyte count, haematinic assays and occasionally bone marrow examination, will detect the underlying pathology in most cases. Anaemia may be classified, according to red blood cell mean corpuscular volume, into microcytic, macrocytic and normocytic types. Anaemia with an absolute reticulocytosis is due either to acute blood loss or haemolysis. Other anaemias, more frequently encountered in elderly patients, are hypoproliferative, and reflect depressed marrow production or impaired erythroid maturation. Examples include anaemia of chronic disease and iron deficiency and, less commonly, megaloblastic anaemia and anaemia due to primary bone marrow failure. The treatment of anaemia should aim to correct the underlying cause of the disorder and/or to improve the quality of the blood, e.g. by haematinic replacement therapy. Recombinant human erythropoietin has revolutionised the treatment of anaemia associated with chronic renal failure, while its role in other anaemias is currently under investigation. Regular blood transfusion may be required for some elderly patients with chronic anaemia. However, the attendant risks of this procedure, such as iron overload and viral hepatitis transmission, must be considered.

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“…Many hematologic studies have indicated that there is a normal decline in the RBC count and Hb level with age. Nevertheless, a few investigators have concluded that there is no change in these measurements in the absence of some pathologic process 16,17 . This difference seems to be mainly due to a bias in selection of the subjects studied.…”

Section: Discussionmentioning

confidence: 97%

“…Although several modifications of the original Metz method have been developed, 16,17 they are still too complicated for clinical use. We modified Wickramasinghe's method by applying a multiple automatic cell harvester.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Aging Changes Evaluated by the Deoxyuridine Suppression Test

Okabe

Ishizawa

Ishii

et al. 1982

J American Geriatrics Society

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Many hematologic studies have shown that the erythrocyte count decreases while the size of the individual cell increases in the aged. This study was performed in order to (1) evaluate changes in the blood erythrocyte level and mean erythrocyte size in the elderly and (2) evaluate use of the deoxyuridine (dU) supression test to determine whether deficiency of vitamin B12 or folate plays any role in age-related changes of hematopoiesis. Selected for study were 102 healthy men whose ages ranged from 20 to 79 years. The erythrocyte count and hemoglobin level decreased significantly, whereas the mean corpuscular volume and mean corpuscular hemoglobin increased after 70 years of age. Fresh bone-marrow cells were obtained from 10 young (20-38 yr) and 10 aged (70-82 yr) men. Wickramasinghe's dU suppression test was modified by application of an automatic cell harvester. The results were normal in both groups. Thus, the route of dU to dTMP in a DNA synthetic pathway appeared intact, and there was no evidence of B12 or folate deficiency in the aged to explain the observed macrocytosis. However, 3H-thymidine uptake by nucleated bone-marrow cells was significantly decreased, and the ratio of 3H-uridine to 3H-thymidine uptake was greater in the old group than in the young group. These results could be explained by altered nucleic acid metabolism (unbalanced cell growth) or by a change in the proportion of the different fractions of nucleated cells.

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Erythrocyte Parameters in the Elderly: An Argument Against New Geriatric Normal Values*

Cited by 40 publications

References 9 publications

Granulopoiesis in Aged People: Inverse Correlation between Bone Marrow Cellularity and Myeloid Progenitor Cell Numbers

Granulopoiesis in Aged People: Inverse Correlation between Bone Marrow Cellularity and Myeloid Progenitor Cell Numbers

Identification and Treatment of Anaemia in Older Patients

Erythrocyte Aging Changes Evaluated by the Deoxyuridine Suppression Test

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