Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

He, Zhouqing; Yu, Chuyi; Pan, Zhifang; Li, Xiaobo; Zhang, Xiangxiang; Huang, Qijing; Liao, Xingcheng; Hu, Jiaoting; Zhu, Feng; Ru, Li; Yu, Wanlin; Xu, Qin; Shen, Jianping; Liang, Jianming

doi:10.1186/s12951-022-01709-x

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…berghei ANKA ( P.b ANKA) were used in this study. The infected model was built according to our previous report . Briefly, the mice were infected via intraperitoneal (i.p.)…”

Section: Resultsmentioning

confidence: 99%

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Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

Liu

Wang

et al. 2023

J. Med. Chem.

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Recently, artemisinin and derivatives have been revealed to possess encouraging antitumor activity. Herein, we integrated the antitumor advantages of artesunate and platinum drugs to construct novel Pt IV −artesunate dual-action and tripleaction complexes. Most derivatives, especially 10f, displayed broadspectrum and potent in vitro antitumor activities against a number of cancer cell lines. Compound 10f displayed potent antimetastasis and anticlonogenic activities, efficiently induced autophagic cell death and apoptosis, and arrested the cell cycle at both S and G2/M phases. More importantly, it displayed remarkable in vivo antitumor efficacy in the A549 xenograft model (TGI = 53.4%; 6 μmol/kg) with low toxicity. In addition to the antitumor application, 10f showed potent in vivo antimalarial activity in malarial-infected mice model and obviously alleviated malarial-related multiorgan injury. This conjugation greatly improved safety, especially reducing the platinum drugs' nephrotoxicity. Taken together, this study highlighted the therapeutic potential of Pt IV −artesunate complexes as antitumor and antimalarial agents.

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“…berghei ANKA ( P.b ANKA) were used in this study. The infected model was built according to our previous report . Briefly, the mice were infected via intraperitoneal (i.p.)…”

Section: Resultsmentioning

confidence: 99%

“…The infected model was built according to our previous report. 71 Briefly, the mice were infected via intraperitoneal (i.p.) injection of blood samples from malarialinfected mice.…”

Section: 13mentioning

confidence: 99%

Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

Liu

Wang

et al. 2023

J. Med. Chem.

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“…Apart from further understanding the pathological hallmarks of placental malaria (PM), it is more realistic to discuss the biologics intended to prevent or treat malaria in this vulnerable population. We previously reported that the erythrocyte membrane biomimetic nanodecoy prepared through a simple self-assembly program could block the invading parasites, producing a remarkable therapeutic effect [37] . Unfortunately, a further research should be conducted on the anti-malarial effects in the process of PAM.…”

Section: Discussionmentioning

confidence: 99%

A new model of pregnacy-associated malaria for inducing adverse pregnancy outcomes in ICR mice

Zhang

Xing

et al. 2023

Preprint

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Backgroud：Based on understanding of placental pathological features and safe medication in pregnancy-associated malaria (PAM), establishment of a stable pregnant mice infection model with Plasmodium was urgently needed. Methods: ICR mice were randomly divided into pre-pregnancy infection, post-pregnancy infection, and uninfected pregnancy cohorts. The mice were inoculated with 1×106 Plasmodium berghei ANKA-infected RBCs by intraperitoneal injection, and the same amount of saline was given to uninfected pregnancy group. We recorded the incidence of adverse pregnancy outcomes and the amounts of offspring in each group. Results: The pre-pregnancy infection group mice were unable to conceive normally, and vaginal bleeding, abortion, or stillbirth appeared in the post-pregnancy infection group. The incidence of adverse pregnancy outcomes was extremely high and statistically significant compared with the control (Malaria-) group (P < 0.05), of which placenta exhibited pathological features associated with human gestational malaria. Conclusions: The intraperitoneal injection of 1×106 Plasmodium berghei ANKA-infected RBCs can establish a murine model of post-pregnancy malaria infection.

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A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

Wu,

Wang,

Shen

et al. 2024

Adv Funct Materials

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Bacterial infection at wound sites can easily induce robust inflammation. M1 macrophages at wound sites can cause cascade inflammatory reactions to mediate a vicious inflammation cycle. Meanwhile, the hypoxia situation further aggravates the destruction and contraction of blood vessels in the wound microenvironment, therefore, hindering the infected wound healing process. Here, a thermosensitive hydrogel is reported to solve the above challenges by eliminating bacteria based on the photothermal effect, regulating the inflammatory immune microenvironment, and providing oxygen (O2). In vitro and in vivo experiments confirmed that the hydrogel has great O2‐producing properties. Based on the excellent photothermal properties of AIEgens, the hydrogel has a good bactericidal effect against S. aureus (100%) and E. coli (98.85%). The RNA‐sequencing revealed that Cur@AIE@MnO2/gel can interfere with the metabolic process and genetic material repair process to impact bacteria proliferation and biofilm dispersal, thus achieving excellent anti‐bacterial efficacy. Moreover, Cur@AIE@MnO2/gel can also up‐regulate anti‐inflammatory genes, down‐regulate pro‐inflammatory genes in macrophages, and facilitate the promotion of macrophage polarization from M1 to M2 to relieve inflammation. The therapeutic experiments show that this hydrogel accelerated the wound‐healing process. Therefore, this work may open new avenues for the development of novel dressings for bacterial‐infected wounds.

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Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

Cited by 4 publications

References 53 publications

Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

A new model of pregnacy-associated malaria for inducing adverse pregnancy outcomes in ICR mice

A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

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Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

Cited by 4 publications

References 53 publications

Discovery of PlatinumIV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

Discovery of PlatinumIV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

A new model of pregnacy-associated malaria for inducing adverse pregnancy outcomes in ICR mice

A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

Contact Info

Product

Resources

About

Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents

Discovery of Platinum^IV–Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents