Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: a preliminary study

Pandey, Manoj; Khatri, Ajay K.; Dubey, Som Shankar; Gautam, Anju; Shukla, Vijay K.

doi:10.1016/s0748-7983(98)80124-8

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…Already in the 1980s it was reported that several cancers, including breast cancer, are having lower desaturation index (C18:0/C18:1) in their erythrocyte membranes when compared to controls, and that this trend is seen in patients with recurrent tumors when compared to nonrecurrent patients . The results have been replicated in several studies including patients with gallbladder carcinoma, colorectal carcinoma, bronchogenic carcinoma and in leukaemias, although also some controversial studies exist . An Italian prospective study comprising 4,052 postmenopausal women, of whom 71 developed invasive breast cancer during the follow‐up, revealed that the levels of oleic acid were significantly positively correlated to breast cancer risk .…”

Section: Discussionmentioning

confidence: 98%

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

Hilvo

Gade

Hyötyläinen

et al. 2013

Intl Journal of Cancer

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Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy.Breast cancer is the most common cancer in women worldwide. In the western world, approximately one in eight women will develop an invasive breast carcinoma. The major treatment options for breast cancer are surgery, radiotherapy, chemotherapy as well as hormonal and antibody therapies. Neoadjuvant chemotherapy provides an equally effective alternative to adjuvant chemotherapy.

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Section: Discussionmentioning

confidence: 98%

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

Hilvo

Gade

Hyötyläinen

et al. 2013

Intl Journal of Cancer

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“…low-erythrocyte-membrane SI is associated with increased risk of breast and other cancers has been tested in several case-control studies (10)(11)(12)(13)28) with conflicting results, although all of the studies were small and had cross-sectional designs. Our finding of an inverse association between red blood cell membrane SI and postmenopausal breast cancer risk is consistent with the results of a Swedish cohort study (14) in which high plasma SI was found to be inversely associated with breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study

Pala¹,

Krogh²,

Muti³

et al. 2001

JNCI Journal of the National Cancer Institute

189

164

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Background:The relationship between erythrocyte membrane fatty acids and postmenopausal breast cancer risk was analyzed previously only by retrospective studies, which suggested a protective effect of increased saturation index (SI), i.e., the ratio of membrane stearic to oleic acid. We investigated the relationships in a prospective study of hormones, diet, and prediagnostic breast cancer (the ORDET study) conducted in northern Italy. Methods: A total of 4052 postmenopausal women were followed for an average of 5.5 years; 71 cases of invasive breast cancer were identified. For each case subject, two matched control subjects were chosen randomly from among cohort members. The various fatty acids in erythrocyte membranes were measured as a percentage of total fatty acids. Conditional logistic regression analysis evaluated the association between membrane fatty acid composition and breast cancer risk. The SI, which is influenced by the activity of the enzyme delta 9 desaturase (⌬9-d), was also investigated. All statistical tests were twosided. Results: Oleic (highest versus lowest tertile of percentage of total fatty acids, odds ratio [OR] = 2.79; 95% confidence interval [CI] = 1.24 to 6.28) and monounsaturated fatty acids (highest to lowest tertile, OR = 5.21; 95% CI = 1.95 to 13.91) were positively associated with breast cancer risk. The SI (highest to lowest tertile, OR = 0.29; 95% CI = 0.13 to 0.64) was inversely associated with breast cancer risk. The analysis suggested an inverse association between total polyunsaturated fatty acids and breast cancer risk, but individual polyunsaturated fatty acids behaved differently. There was no association between saturated fatty acids and breast cancer risk. Conclusions: We have found that monounsaturated fats and SI in erythrocyte membranes

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“…However, in preliminary study [9], this fall in SI was primarily due to fall in the content of stearic acid and increase in oleic acid in patients with carcinoma of the gallbladder. We did not observe a significant rise in the level of oleic acid in carcinoma patients, however, fall in the levels of stearic acid were significant in this study.…”

Section: Discussionmentioning

confidence: 99%

“…An increase in delta 9 desaturation and lowering of saturation index has been observed in colorectal cancer [4], bronchogenic carcinoma [5], lymphoma [6], leukemia [7], malignant liver neoplasms [8,9] as well as in gallbladder cancer [10]. Hence on one hand the saturation index might prove to be a diagnostic marker of malignancy, the fatty acid profile changes might provide a clue to carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Untitled

et al. 2003

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BackgroundGallbladder cancer is a common neoplasm of biliary tract, with an unknown etiology.Patients and methodsThis study was carried out to evaluate the changes in the membrane fatty acid profile and saturation index in patients with gallbladder cancer. The study sample consisted of 50 newly diagnosed cases of gallbladder cancer and 50 patients undergoing cholecystectomy for cholelithiasis were recruited as controls. The fatty acid estimation was carried out by high performance liquid chromatography (HPLC). Statistical analysis was carried out by student 't' test and one-way ANOVA. Pearson's correlation coefficient was also obtained.ResultsA significant lowering of erythrocyte membrane stearic acid (p = 0.000), arachidonic acid (p = 0.001), and saturation index (p = 0.001) was observed in patients with gallbladder cancer compared to controls. A significant inverse relation was observed between stearic and oleic acid (r = -0.269 p = 0.007).ConclusionResults of the present study suggest an increase in the delta 9 desaturation in cancer patients compared to controls however, a possible role of biliary stasis due to altered gallbladder motility or derangements of signal transduction secondary to altered membrane lipid bilayer cannot be ruled out.

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Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: a preliminary study

Cited by 16 publications

References 16 publications

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study

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