Erythrocyte membrane protein damage by phenoxyacetic herbicides and their metabolites

Duchnowicz, Piotr; Szczepaniak, Piotr S.; Koter, Maria

doi:10.1016/j.pestbp.2004.12.004

Cited by 37 publications

(14 citation statements)

References 20 publications

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“…There are great number of different drugs and environmental toxicants which modulate the sodium pump activity in the concentration dependent manner [42-54]. The most frequently investigated sodium pump inhibitors are natural and synthesized cardiotonic steroids and their derivatives [55], endogenous ouabain like inhibitors, isolates from natural plants, pharmaceutically important organic and inorganic compounds, antitumor drugs, biologically relevant metal ions, pesticides, herbicides and organic solvents.…”

Section: Inhibition Of Na+k+-atpase Activitymentioning

confidence: 99%

“…The Na + ,K + -ATPase used in the inhibition studies could be isolated from different sources (rat brain, dog kidney, porcine cerebral cortex, human blood) [48, 52, 54, 67]. Each choice of the Na + ,K + -ATPase source, i.e.…”

Section: Inhibition Of Na+k+-atpase Activitymentioning

confidence: 99%

“…However, the activity of Na + ,K + -ATPase may be affected by various endogenous and exogenous factors [42-54]. The regulation of Na + ,K + -ATPase activity in various tissues is under the control of a number of circulating hormones that impart both short- and long-term control over its activity [44, 45].…”

Section: Introductionmentioning

confidence: 99%

“…Also, the activity of the enzyme is dependent on the lipid status of the membrane [46]. Although the mechanism of the toxic effect of various Na + ,K + -ATPase activity modulators has not been completely understood yet, this enzyme can be taken as meaningful index of cellular activity and represents a useful toxicological tool [54]. …”

Section: Introductionmentioning

confidence: 99%

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Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds

Vasić

Momić

Petković

et al. 2008

Sensors

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This paper gives an overview of the literature data concerning specific and non specific inhibitors of Na+,K+-ATPase receptor. The immobilization approaches developed to improve the rather low time and temperature stability of Na+,K+-ATPase, as well to preserve the enzyme properties were overviewed. The functional immobilization of Na+,K+-ATPase receptor as the target, with preservation of the full functional protein activity and access of various substances to an optimum number of binding sites under controlled conditions in the combination with high sensitive technology for the detection of enzyme activity is the basis for application of this enzyme in medical, pharmaceutical and environmental research.

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Section: Inhibition Of Na+k+-atpase Activitymentioning

confidence: 99%

Section: Inhibition Of Na+k+-atpase Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds

Vasić

Momić

Petković

et al. 2008

Sensors

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“…Furthermore, exposure to Agent Orange and other herbicides has been shown to lead to adverse health effects and cause genetic damage in humans (Hardell and Sandstrom, 1979;Eriksson et al, 1981;Schecter et al, 1995;Akhtar et al, 2004;Bukowska, 2004;Palmer, 2005;Duchnowicz et al, 2005).…”

mentioning

confidence: 99%

Elevated sister chromatid exchange frequencies in New Zealand Vietnam War veterans

Rowland¹,

Edwards²,

Podd

2007

Cytogenet Genome Res

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From July 1965 until November 1971, New Zealand Defence Force Personnel fought in the Vietnam War. During this time more than 76,500,000 litres of phenoxylic herbicides were sprayed over parts of Southern Vietnam and Laos, the most common being known as ‘Agent Orange’. The current study aimed to ascertain whether or not New Zealand Vietnam War veterans show evidence of genetic disturbance arising as a consequence of their now confirmed exposure to these defoliants. A sample group of 24 New Zealand Vietnam War veterans and 23 control volunteers were compared using an SCE (sister chromatid exchange) analysis. The results from the SCE study show a highly significant difference (P < 0.001) between the mean of the experimental group (11.05) and the mean of a matched control group (8.18). The experimental group also has an exceptionally high proportion of HFCs (cells with high SCE frequencies) above the 95th percentile compared to the controls (11.0 and 0.07%, respectively). We conclude that the New Zealand Vietnam War veterans studied here were exposed to a clastogenic substance(s) which continues to exert an observable genetic effect today, and suggest that this is attributable to their service in Vietnam.

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Exposure of African Catfish (Clarias gariepinus) to Lead and Zinc Modulates Membrane-Bound Transport Protein: A Plausible Effect on Na+/K+-ATPase Activity

Apiamu

Osawaru

Asagba

et al. 2021

Biol Trace Elem Res

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The contamination of the aquatic ecosystem beyond tolerable limits may pose serious health challenges to its components. This study evaluated the toxic effects of a binary mixture of lead (Pb) and zinc (Zn) compounds on the activity of Na + /K + -ATPase in tissues of Clarias gariepinus in a controlled aquatic system. The study employed Box-Behnken Design (BBD) with 17 runs in which Pb and Zn concentrations were considered process variables in a time-dependent fashion. Metal exposure levels consisted of 0, 10 and 20% of 96 h-LC 50 of Pb (55.12 mg/L) and Zn (32.15 mg/L) for three weeks. Thereafter, membrane-bound Na + /K + -ATPase activity was assessed in gill, hepatic and renal tissues, and data generated from the BBD were used for the development of models. Three regression models were obtained, for gill, hepatic and renal Na + /K + -ATPase activities with exposure to metals differ significantly (p < 0.05) at R 2 > 90%, and no significant lack of fit (p > 0.05) was observed in each case. Congruent to the synergistic interactions observed between Pb and Zn in the study, the gill and hepatic Na + /K + -ATPase activities were significantly inhibited, whereas renal Na + /K + -ATPase activity was significantly stimulated (p < 0.05). The optimized models were considered reliable, as they were confirmed in the laboratory through accurate prediction of hepatic, renal and gill Na + /K + -ATPase activities with equivalences of 1.22 ± 0.17, 1.66 ± 0.07 and 3.50 ± 0.33 µmol p i /min/mg protein (p < 0.05) respectively. It is hereby concluded that the synergistic interaction between Pb and Zn truncated the physiological function of Na +/ K + -ATPase activity in the respective tissues except for renal tissue of exposed C. gariepinus. Keywords C. gariepinus • Lead • Na + /K + -ATPase activity • Toxic effects • Zinc * Augustine Apiamu

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Erythrocyte membrane protein damage by phenoxyacetic herbicides and their metabolites

Cited by 37 publications

References 20 publications

Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds

Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds

Elevated sister chromatid exchange frequencies in New Zealand Vietnam War veterans

Exposure of African Catfish (Clarias gariepinus) to Lead and Zinc Modulates Membrane-Bound Transport Protein: A Plausible Effect on Na+/K+-ATPase Activity

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