Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation

Abstract

SummaryBuckground and hypothesis: The mechanism of sudden cardiac death occurring in patients with chronic fatigue is controversial. This study was designed to define a hypothesis that coronary arterial spasm and thrombus formation can occur during chronic fatigue.Meth0d.Y: For evaluating the feasibility of coronary arterial spasm, erythrocyte magnesium (Mg) was measured. Blood coagulability was evaluated by the change of prostaglandin concentration. Subjects included 16 healthy male volunteers (mean age 2 I .6 2.5 years). Test conditions were as follows: Conclusion: These findings could support the hypothesis that coronary arterial spasm and thrombus formation oxcur in chronic sleep deprivation.

Effect of chronic stress and sleep deprivation on both flow‐mediated dilation in the brachial artery and the intracellular magnesium level in humans

“…19 In addition, both experimental and human studies revealed that mental and psychosocial stress decrease endothelial function. 11,20,21 According to Tanabe et al 's reports,4,6 the decreased levels of intracellular magnesium in this study were identical to those between temporary and persistent sleep deprivative conditions; they are thus considered to be a reflection of sleep deprivation in our study protocol.…”

“…Sleep deprivation has been reported to decrease the intracellular magnesium level in humans, 4,6 and mental stress has also recently been reported to cause transient endothelial dysfunction in the brachial artery in humans; 11 however, the relationship between intracellular magnesium levels and endothelial function has not yet been fully investigated. Magnesium is considered to be a physiologic calcium antagonist and has been reported to decrease vascular tone.…”

“…Blood samples were heparinized in order to measure the erythrocyte magnesium concentration and were centrifuged at 3000 ϫ G at 4˚C for 10 min. The erythrocyte magnesium concentration was determined by the atomic absorption method as previously reported, 6 and the value obtained was corrected for the number of erythrocytes; the magnesium concentration was expressed per 400 ϫ 104/mm 3 .…”

“…As a result, magnesium deficiency can cause coronary arterial spasms and lethal arrhythmia in patients with a history of myocardial infarction. 5 In some reports, 4,6 chronic sleep deprivation has been reported to cause magnesium deficiency. Endothelial-dependent and -independent arterial vasomotion is also associated with the pathophysiology of cardiovascular disease.…”

Magnesium in the Central Nervous System

“…Magnesium content in four brain areas was also highly and positively correlated with the length of sleep periods (Chollet et al, 2000). Erythrocyte magnesium concentrations are low in adult human subjects with chronic sleep deprivation (1.1 ± 0.4 mg/dl) versus a control group (1.8 ± 0.4 mg/dl) (Tanabe et al, 1997). The reduction of sleep time is frequently associated with chronic fatigue.…”