Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women

Belury, Martha A.; Cole, Rachel M.; Bailey, Brittney E.; Ke, Jia‐Yu; Andridge, Rebecca; Kiecolt‐Glaser, Janice K.

doi:10.1002/mnfr.201500744

Cited by 43 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, increasing MUFA occurs both at the expense of decreasing PUFA (specifically ALA) and decreasing SFA. One recent study showed that erythrocyte linoleic acid was associated with decreased trunk fat mass in men and women . In conjunction with our finding, this suggests that varying PUFA (LA vs. ALA) may have a different effect on android fat mass.…”

Section: Discussionsupporting

confidence: 89%

Effects of canola and high‐oleic‐acid canola oils on abdominal fat mass in individuals with central obesity

Liu

Kris-Etherton

West

et al. 2016

Obesity

View full text Add to dashboard Cite

Objective To determine the effect of diets low in saturated fatty acids (SFA), high in monounsaturated fatty acids (MUFA) or polyunsaturated fatty acids (PUFA) on body composition in participants at risk for MetS. Methods; The present study is a randomized, crossover, controlled feeding study. Participants (n = 101, ages 49.5 ± 1.2, BMI 29.4 ± 0.4 kg/m2) were randomized to five isocaloric diets contained treatment oils: Canola, CanolaOleic, CanolaDHA, Corn/Safflower and Flax/Safflower. Each diet period was 4-week followed by a 2–4 week washout period. Results Canola (3.1 kg, p=0.026) and CanolaOleic oil diets (3.1 kg, p=0.03) reduced android fat mass compared with the Flax/Saff oil diet (3.2 kg), particularly in males. The decrease in abdominal fat mass was correlated with the reduction in blood pressure after the Canola (SBP r = 0.26, p=0.062; DBP r=0.38, p=0.0049) and CanolaOleic oil diets (SBP r = 0.39 p=0.004; DBP r=0.45, p=0.0006). The decrease in abdominal fat mass also was associated with a reduction in TG levels after the CanolaOleic oil diet (r = 0.42, p=0.002). Conclusion Diets high in MUFA (compared with PUFA) reduced central obesity with an accompanying improvement in MetS risk factors. Our findings demonstrate that diets high in MUFA may be beneficial for treating and perhaps preventing MetS.

show abstract

Section: Discussionsupporting

confidence: 89%

Effects of canola and high‐oleic‐acid canola oils on abdominal fat mass in individuals with central obesity

Liu

Kris-Etherton

West

et al. 2016

Obesity

View full text Add to dashboard Cite

show abstract

“…Consistent with reports in adults, 38,39 we demonstrated that proportions of EPA + DHA in RBC are a useful biomarker to reflect dietary EPA, DHA and fish servings in children with obesity. Other fatty acids in RBC including oleic acid were explored and did not relate to any of the measures of adiposity as has been observed in other studies 40,41 . It is noteworthy that due to possible differences in fatty acids extraction methods and analytic procedures, the range of EPA + DHA in this study appeared to be lower than previously reported 42 .…”

Section: Discussionmentioning

confidence: 70%

Increased adiposity in children with obesity is associated with low red blood cell omega‐3 fatty acid status and inadequate polyunsaturated fatty acid dietary intake

et al. 2020

View full text Add to dashboard Cite

Summary The association between total dietary fat intake and measures of body fatness in children with obesity remains inconsistent. This study aimed to determine whether dietary long‐chain polyunsaturated fatty acids (LCPUFA) and LCPUFA status relate to body composition in children with obesity. Children (n = 63, 9.0 ± 0.2 year, BMI Z‐score 3.1 ± 0.2) were divided into tertiles of percentage body fat assessed by dual‐energy X‐ray absorptiometry. Diet was assessed 3‐days food diaries. Fatty acid proportions in red blood cells (RBC) were measured by gas chromatography. Data stratified by sex and Tanner stages were compared with a MIXED model ANOVA. Associations between RBC fatty acid status and dietary intakes were examined with Spearman correlation. Moderate correlations were observed between RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) proportions, dietary EPA and DHA (r = 0.39, P < .05) as well as fish servings (r = 0.33, P < .05). Dietary LCPUFA did not differ among tertiles. Children in tertile 3 had lower RBC α‐linolenic acid (−40%) and EPA + DHA (−15%) proportions adjusted for age, Tanner stages and race compared with tertile 1. The lower omega‐3 LCPUFA status in children with greater adiposity is consistent with suboptimal intakes of omega‐3 LCPUFA and fish in the diet.

show abstract

“…Indeed, although many of these studies report weight gain and increased adipose inflammation, the final outcome is highly dependent on the whole diet and other external factors such age or physical activity. Some research even showed that dietary supplements with C18:2 increase lean mass 26 . In our study with pigs none of the carcass traits analyzed were affected by the higher FADS2 activity of the A rs321384923 allele.…”

Section: Discussionmentioning

confidence: 99%

A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs

Gol

Pena

Rothschild

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Arachidonic acid (C20:4) is related to a wide range of biological effects including lipid homeostasis. The fatty acid desaturase-2 (FADS2) gene encodes for the delta-6-desaturase, which is involved in the biosynthesis of C20:4 from linoleic acid (C18:2). The purpose of this study was to characterise mutations in the promoter of the porcine FADS2, evaluating in particular the effect of one haplotype tagging polymorphism (rs321384923A > G) on the biosynthesis pathway of C20:4. A total of 1,192 Duroc barrows with records on fatty acid composition in muscle and subcutaneous fat were genotyped. Pigs carrying the A allele showed, irrespective of fat content, both enhanced FADS2 expression and higher C20:4 in muscle and exhibited increased ratios of C20:4 to C18:2 and of C20:4 to eicosadienoic acid (C20:2) in both muscle and adipose tissue. Despite the inverse relationship observed between C20:4 and fat content, the rs321384923 polymorphism had no impact on lean weight. It is concluded that the haplotype encompassing the rs321384923 polymorphism at the porcine FADS2 affects the n-6 fatty acid profile by specifically modifying the desaturation efficiency of C18:2 to C20:4 rather than by concomitant variations in C18:2 following changes in fat content.

show abstract

Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women

Cited by 43 publications

References 35 publications

Effects of canola and high‐oleic‐acid canola oils on abdominal fat mass in individuals with central obesity

Effects of canola and high‐oleic‐acid canola oils on abdominal fat mass in individuals with central obesity

Increased adiposity in children with obesity is associated with low red blood cell omega‐3 fatty acid status and inadequate polyunsaturated fatty acid dietary intake

A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs

Contact Info

Product

Resources

About