Erythrocyte Glyoxalase I and Superoxide Dismutase Polymorphisms in the Mbugu and Some Other Populations of the Central African Republic

Abstract

The rare allele SOD A² was found in a Negroid family of the Central African Republic. The polymorphism of this enzyme and of GLO was investigated in the Mbugu, Sango, Yakpa, and Baya-Mandjia ethnic groups. The results are compared with those of other populations and discussed.

Occurrence of a Rare Variant of Superoxide Dismutase in Brazil

“…Crosti et al [1976] suggested a new differ ent mutational event in Italy at a relatively recent time, and Papiha and Al-Agidi [1976] think that the SOD A2gene found in Iraq originated in Italy. According to Spedini et al [1982] the Central African Re public SOD A2 gene also results from a re cent mutational independent event.…”

Isoelectric Focusing of Superoxide Dismutase: Report of the Unique SODA*2 Allele in a US White Population

“…Several hypotheses have been proposed regarding the origin and distribution of the SOD A*2 allele in different popualation groups [Beckman, 1973;Kirk, 1974;Crosti et al, 1976;Papiha and Al-Agidi, 1976;Spedini et al, 1982;Weimer et al, 1987]. However, the most likely explana tion appears to be that offered by Kirk [ 1974] who suggested that the SOD A *2 al lele was spread across Europe by Vikings through their successive migrations from their homeland in Scandinavia.…”

Regular trisomy 21 not accompanied by increased copper‐zinc superoxide dismutase (SOD1) activity

“…Moreover Marklund et al (1976) showed that the activity of the purified product of the two alleles did not differ significantly. Since the enzyme activity of the two phenotypes SODI-2 and SODl was in the same range, this may suggest that the allele SOD2 is selectively neutral (Spedini et al 1982). Still, little investigation has been carried out yet on the two electrophoretic forms noticed by several authors (Carrico & Deutsch 1970, Beckman et al 1973, Beckman 1973, Tegelstrom 1975, Marklund et al 1976, Crosti 1978 of the crude erythrocyte extract as well as of the purified enzyme of the homozygote phenotype SODl.…”