Erythrocyte Glucose 6‐phosphate Dehydrogenase Deficiency (G6pd Type A‐) and Neonatal Jaundice

Abstract

Bienzle, U., Effong, C. E. and Luzzatto, L. (Departments of Haematology and Paediatrics, University College Hospital, Ibadan, Nigeria). Erythrocyte glucose 6phosphate dehydrogenase deficiency (G6PD type A-) and neonatal jaundice. Acta Paediatr Scand, 65: 701, 1976.-The association of erythrocyte G6PD deficiency (type A-) and hyperbilirubinaemia in two groups of Nigerian male newborns has been examined. The results provide evidence that the enzyme deficiency is the single most important factor in the pathogenesis of severe neonatal jaundice in this West African population. KEY WORDS: Erythrocyte G6PD deficiency, neonatal jaundice

Glucose‐6‐Phosphate Dehydrogenase Deficiency and Neonatal Jaundice in Jamaica

“…If only a small number of infants was exposed randomly to this agent larger numbers than the 21 Group I1 neonates investigated here, the 30 reported by O'Flynn & Hsia (1963) or the 10 studied by Zinkham (1963) may have been required to demonstrate its effect. O n the other hand, the incidence of G6PD deficiency would be high in infants with unexplained hyperbilirubinaemia (Tables I and 11; Tchernia et al, 1971;Nkrumah, 1973;Effiong et al, 1975;Bienzle et al, 1976). We have been unable to identify this agent, but possibilities include metabolic disorders, toxins and foodstuffs.…”

“…However, there have been anecdotal accounts of jaundice severe enough to require exchange transfusions, and occurring in thc absence of any apparent precipitating agents, in American Negro neonates (Lopez & Cooperman, 1971). O n the other hand, a high incidence of G6PD deficiency has been found in moderately or severelyjaundiced African neonates in the Senegal (Tchernia et al, 1971), and in Ghana (Nkrumah, 1973) and Nigeria (Effiong et al, 1975;Bienzle et al, 1976).…”

Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Chinese

“…the 1376 and 1388 variants. Both severe and mild G6PD deficiencies have been reported to be associated with neonatal hyperbilirubinemia (Bienzle et al 1976;Tan KL 1981;Yaish H.M. et al 1991 andMeloni T et al 1983). The number of studies on the relationship between severity of G6PD deficiency based on levels of enzyme activity and the risk of developing severe neonatal hyperbilirubinemia appear to be limited.…”

Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh

“…[ 11 – 13 ] The above complications have been reported in patients with normal G6PD activity. However, in high-prevalence areas of G6PD deficiency, more than 40%[ 14 ] of neonates with jaundice that might require exchange transfusion are G6PD-deficient, hence the incidence and severity of these complications are expected to be higher.…”