Erythrocyte Folate Levels in Young and Old

Webster, Stephen D.; Leeming, Jack

doi:10.1111/j.1532-5415.1979.tb01725.x

Cited by 31 publications

(12 citation statements)

References 11 publications

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“…Our data are also limited by the fact that no central laboratory was used in the CSHA. Red blood cell folate is a better measure of tissue levels than serum folate, which is more sensitive to abrupt changes in intake [60]. Our analyses were also restricted to baseline folate measures and there may have been significant changes in these levels during follow-up related to changes in dietary intake and/or use of vitamin supplements.…”

Section: Discussionmentioning

confidence: 99%

Serum Folate Levels and Subsequent Adverse Cerebrovascular Outcomes in Elderly Persons

Maxwell¹,

Hogan²,

Ebly³

2002

Dement Geriatr Cogn Disord

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Recent epidemiologic studies have shown an association between low serum folate levels and risk of vascular disease, including stroke and various types of vascular cognitive impairment. We examined data from the Canadian Study of Health and Aging (CSHA), a population-based, prospective 5-year investigation of the epidemiology of dementia among Canadians aged 65+ years. The risk of an adverse cerebrovascular event (including vascular dementia, vascular cognitive impairment, or fatal stroke) during follow-up, was assessed according to serum folate quartiles among subjects with no evidence of dementia at baseline (n = 369). After adjusting for certain covariates, including cardiovascular disease and nutritional indices, education, smoking and baseline cognitive status, the risk estimate for an adverse cerebrovascular event associated with the lowest folate quartile compared with the highest quartile was OR 2.42 (95% CI 1.04–5.61). Results from stratified analyses also showed that relatively low serum folate was associated with a significantly higher risk of an adverse cerebrovascular event among female (OR 4.02, 95% CI 1.37–11.81) but not male (OR 1.02, 95% CI 0.25–4.13) subjects. Among the total sample, there was a consistent trend toward poorer health and cognitive outcomes during follow-up (including mortality, cognitive decline and dementia) among those in the lowest folate quartile compared with the highest quartile. Low serum folate levels are independently associated with a significantly higher risk of an adverse cerebrovascular event, including vascular dementia and stroke death, among older, cognitively vulnerable persons.

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Section: Discussionmentioning

confidence: 99%

Serum Folate Levels and Subsequent Adverse Cerebrovascular Outcomes in Elderly Persons

Maxwell¹,

Hogan²,

Ebly³

2002

Dement Geriatr Cogn Disord

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“…Vitamin B 12 deficiency occurs in 10-20% (Nilsson-Ehle, 1998), folate deficiency in 3-19% (Webster & Leeming, 1979;Joosten et al, 1993;Matthews, 1995). Vitamin B 6 might be more important for normal P-tHcys than previously appreciated (McKinley et al, 2001), but sometimes causes elevated P-tHcys only after methionine loading (Ubbink et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial

et al. 2003

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Objectives: To investigate, in an elderly population: (1) the effects of oral B-vitamin therapy on P-tHcys, S-MMA and Hb/MCV, (2) the appropriate decision limit for 'high' metabolite concentrations and (3) the estimated prevalence of vitamin B 12 /folate deficiency on the basis of different decision limits. Design: Double-blind placebo-controlled intervention study. Setting: Outpatient clinic. Subjects: A total of 209 community-dwelling subjects, median age 76 y (range 70-93) y. Intervention: Four months of oral daily supplementation with 0.5 mg cyanocobalamin, 0.8 mg folic acid and 3 mg vitamin B 6 . Results: High P-tHcys was found in 64% of men and 45% of women, high S-MMA in 11% of both. Vitamin B 12 deficiency was observed in 7.2% and folate deficiency in 11% of all subjects. Health-related upper reference limits for the metabolites at the start were higher than the laboratory's upper reference limits. The latter were, however, similar to those of the vitamin replete group. There was a significant decrease in P-tHcys (Po0.001) and S-MMA (P ¼ 0.009) after 4 months of vitamin treatment. In a multivariate analysis, the P-Hcys change correlated positively with baseline P-tHcys and inversely with baseline P-folate and transferrin saturation (Fe/TIBC ratio). The S-MMA change correlated with baseline S-MMA and inversely with baseline vitamin B 12 and age. Conclusions: Suboptimal vitamin status is an important cause of elevated P-tHcys and S-MMA in apparently healthy elderly subjects. Oral B-vitamin therapy is an effective and convenient way to normalise P-tHcys and S-MMA. Sponsorship: SupportFRecip AB.

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“…Some investigators have found a decrease in the serum vitamin B 12 level in the aged 19,20 whereas others have found that the serum B 12 level remains constant throughout life 21,22 . Similarly, in some studies, measurements of serum and erythrocyte folate concentration in the aged have shown that the level is unchanged, 21,23 whereas in other studies these concentrations have been shown to decrease with age 24–25 . Assays of vitamin B 12 or folate have certain disadvantages.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Aging Changes Evaluated by the Deoxyuridine Suppression Test

Okabe

Ishizawa

Ishii

et al. 1982

J American Geriatrics Society

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Many hematologic studies have shown that the erythrocyte count decreases while the size of the individual cell increases in the aged. This study was performed in order to (1) evaluate changes in the blood erythrocyte level and mean erythrocyte size in the elderly and (2) evaluate use of the deoxyuridine (dU) supression test to determine whether deficiency of vitamin B12 or folate plays any role in age-related changes of hematopoiesis. Selected for study were 102 healthy men whose ages ranged from 20 to 79 years. The erythrocyte count and hemoglobin level decreased significantly, whereas the mean corpuscular volume and mean corpuscular hemoglobin increased after 70 years of age. Fresh bone-marrow cells were obtained from 10 young (20-38 yr) and 10 aged (70-82 yr) men. Wickramasinghe's dU suppression test was modified by application of an automatic cell harvester. The results were normal in both groups. Thus, the route of dU to dTMP in a DNA synthetic pathway appeared intact, and there was no evidence of B12 or folate deficiency in the aged to explain the observed macrocytosis. However, 3H-thymidine uptake by nucleated bone-marrow cells was significantly decreased, and the ratio of 3H-uridine to 3H-thymidine uptake was greater in the old group than in the young group. These results could be explained by altered nucleic acid metabolism (unbalanced cell growth) or by a change in the proportion of the different fractions of nucleated cells.

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Erythrocyte Folate Levels in Young and Old

Cited by 31 publications

References 11 publications

Serum Folate Levels and Subsequent Adverse Cerebrovascular Outcomes in Elderly Persons

Serum Folate Levels and Subsequent Adverse Cerebrovascular Outcomes in Elderly Persons

Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial

Erythrocyte Aging Changes Evaluated by the Deoxyuridine Suppression Test

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