Erythrocyte enzymes of Glyoxalase system as indicators of beneficial effects of antihyperglycemic agents in Type 2 Diabetes

Patke, Vinay; Saroj, Sarvesh R.

doi:10.18203/2320-6012.ijrms20150245

Cited by 2 publications

(4 citation statements)

References 24 publications

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“…This study showed that metformin + sulfonylureas 162 (54.00%) dual drug regime was the commonly used in most of the patients and which was similar in the study conducted by Lahiry S. 4 It is followed by Metformin + regular insulin 132 (44.00%) and Metformin+thiazolidine diones 80 (26.66%).…”

Section: Percentagesupporting

confidence: 79%

“…Dual drug regimens as a dual medication regime in 44 prescriptions with metformin because of considerable postprandial hyperglycemia with managed Fasting Plasma Glucose (FPG) in majority of these follow-up encounters, this was done in accordance with the 2016 standards of the International Diabetes Federation. 4 Only 102 prescriptions out of 300 patients contained Voglibose 54 (18.00%), Acarbose 32 (10.66%) and Miglitol 16 (05.33%) where similar results found in the study by Lahiry S et al It was against the evidence supporting the use of acarbose as a first-line adjuvant for lowering cardiovascular mortality in T2DM patients when compared to voglibose. 4 Overall, thiazolidinediones are used as monotherapy by 80 (17.66%) of patients, with pioglitazone and rosiglitazone being used as add-on therapy by 53 (17.66%) and 27(09.00%) of patients, respectively and similar result by Pankaj CK et al 5 In 80 (26.66%) of the prescriptions, metformin and thiazolidinediones were prescribed together.…”

Section: Percentagesupporting

confidence: 59%

“…4 Only 102 prescriptions out of 300 patients contained Voglibose 54 (18.00%), Acarbose 32 (10.66%) and Miglitol 16 (05.33%) where similar results found in the study by Lahiry S et al It was against the evidence supporting the use of acarbose as a first-line adjuvant for lowering cardiovascular mortality in T2DM patients when compared to voglibose. 4 Overall, thiazolidinediones are used as monotherapy by 80 (17.66%) of patients, with pioglitazone and rosiglitazone being used as add-on therapy by 53 (17.66%) and 27(09.00%) of patients, respectively and similar result by Pankaj CK et al 5 In 80 (26.66%) of the prescriptions, metformin and thiazolidinediones were prescribed together. It's possible that pioglitazone was dispensed from the hospital pharmacy.…”

Section: Percentagesupporting

confidence: 59%

“…World Health Organization (WHO) has been putting efforts globally to prevent risk and provide equitable, comprehensive and affordable care to ensure quality treatment. 4 Several standardised guidelines have been proposed by American Diabetes Association and Indian Council of Medical Research for effective care and managment Diabetes. Diabetes management either by insulin 5 or non-insulin 6 therapies have seriously associated comorbidities namely hypoglycemia, weight gain etc.…”

Section: Introductionmentioning

confidence: 99%

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Drug Utilization Evaluation of Antidiabetic Drugs in a Tertiary Care Teaching Hospital: Analysis from a Randomized Controlled Study

Nyamagoud,

Swamy,

Kangrali

2023

Int J. Pharm. Investigation

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Background: Diabetes Mellitus (DM) is a chronic metabolic condition characterized by high blood glucose levels and changes in carbohydrate, lipid and protein metabolism due to insulin secretion, action, or both. 1 Diabetes affects 537 million persons worldwide in 2021 and its management and selection of antidiabetic drugs is a major health concern. Objectives: The study was aimed to evaluate the prescription pattern of antidiabetic drugs in a tertiary care hospital in Hubballi, Karnataka. Materials and Methods: It was a Prospective randomized controlled study where the participants were randomized into two groups i.e., the interventional or study group and control group. Results: Of the 300 diabetic patients, 150 were included in the control group and another 150 in the observational group in which 218 (72.6%) were males and 82 (27.3%) were females. Males were higher than females. The maximum number of patients were in the age group of 61-70 years, followed by 51-60 years. 175 (58.33%) subjects were taking two medications followed by 82 (27.33%) were receiving three medications. 152 (50.66%) were receiving diabetic medications two times in a day followed 122 (40.66%) were taking once in a day. Out of 300 Patients, 205 (68.33%) patients were prescribed insulin, of which regular insulin was the highest. Conclusion: It was found that metformin and insulin use is greater with higher use among middle-age patients. Regular insulin was the most often used insulin.

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Section: Percentagesupporting

confidence: 79%