Erythrocyte Deformability and Oxidative Stress in Inflammatory Bowel Disease

Akman, Tülay; Akarsu, Mesut; Akpınar, Hale; Resmi, Halil; Sezer, Ebru

doi:10.1007/s10620-011-1882-9

Cited by 19 publications

(17 citation statements)

References 47 publications

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“…In the present study, alterations in colonic SOD and GPx (Figures 4(f) and 4(j)) in the mild colitis group were not observed, which is similar to data reported by Akman et al [38], who studied patients with active intestinal inflammation. On the other hand, the lower SOD activity observed in the NAC versus LA group, without evidence of increased H 2 O 2 levels, confirms the major antioxidant power of NAC in our model.…”

Section: Discussionsupporting

confidence: 92%

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Moura

Andrade

Araújo³

et al. 2016

Oxidative Medicine and Cellular Longevity

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Lipoic acid (LA) and N-acetylcysteine (NAC) are antioxidant and anti-inflammatory agents that have not yet been tested on mild ulcerative colitis (UC). This study aims to evaluate the action of LA and/or NAC, on oxidative stress and inflammation markers in colonic and hepatic rat tissues with mild UC, induced by dextran sodium sulfate (DSS) (2% w/v). LA and/or NAC (100 mg·kg·day−1, each) were given, once a day, in the diet, in a pretreatment phase (7 days) and during UC induction (5 days). Colitis induction was confirmed by histological and biochemical analyses (high performance liquid chromatography, spectrophotometry, and Multiplex®). A redox imbalance occurred before an immunological disruption in the colon. NAC led to a decrease in hydrogen peroxide (H2O2), malondialdehyde (MDA) levels, and myeloperoxidase activity. In the liver, DSS did not cause damage but treatments with both antioxidants were potentially harmful, with LA increasing MDA and LA + NAC increasing H2O2, tumor necrosis factor alpha, interferon gamma, and transaminases. In summary, NAC exhibited the highest colonic antioxidant and anti-inflammatory activity, while LA + NAC caused hepatic damage.

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Section: Discussionsupporting

confidence: 92%

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Moura

Andrade

Araújo³

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…For instance, some authors observed no difference [57] , decreased [58] or increased levels [14] , in plasma/erythrocyte, of antioxidant enzymes in patients with active intestinal inflammation. In a study [16] , the authors showed significant modifications regards levels of OS markers in the serum of patients with active IBD, such as decreased SOD and GPx activity, and a low antioxidant profile and increased lipid peroxidation in patients in the remission phase.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

et al. 2015

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Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Some of the challenges identified in this review can shed light on this fact: lack of standardization of OS biomarkers, absence of safety data and clinical trials for the chemicals and biological molecules, as well as the fact that most of the compounds were not repeatedly tested in several situations, including acute and chronic colitis. This review hopes to stimulate researchers to become more involved in this fruitful area, to warrant investigation of novel, alternative and efficacious antioxidant-based therapies.

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“…For example, serum G-Px enzyme activity is higher in CD patients than in healthy controls, differences that disappeared when patients were in the inactive phase (with bowel rest and no signs of symptoms of the disease) [ 48 ]. Nevertheless, in a more recent study no differences of plasma G-Px were found between CD patients with active (clinical activity, sign, and symptoms of the disease) or inactive phase and healthy controls [ 49 ]. Meanwhile, another study found decreased G-Px activities in patients with CD [ 44 ].…”

Section: Oxidative Stress Biomarkers In Blood Of Crohn's Disease Pmentioning

confidence: 99%

Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel

Moret

Iborra²,

Cerrillo³

et al. 2016

Oxidative Medicine and Cellular Longevity

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Crohn's disease (CD) is an inflammatory disorder characterised by a transmural inflammation of the intestinal wall. Although the physiopathology of the disease is not yet fully understood, it is clear that the immune response plays an important role in it. This hyperreactive immune system is accompanied by the presence of unregulated reactive oxygen species (ROS). These elements are modulated in normal conditions by different elements, including enzymes that function as antioxidant defences preventing the harmful effects of ROS. However, in CD there is an imbalance between ROS production and these antioxidant elements, resulting in oxidative stress (OxS) phenomena. In fact, now OxS is being considered more a potential etiological factor for Crohn's disease rather than a concomitant effect in the disease. The persistence of the OxS can also be influencing the evolution of the disease. Furthermore, the epigenetic mechanisms, above all microRNAs, are being considered key elements in the pathogenesis of CD. These elements and the presence of OxS have also been linked to several diseases. We, therefore, describe in this review the most significant findings related to oxidative stress and microRNAs profiles in the peripheral blood of CD patients.

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Erythrocyte Deformability and Oxidative Stress in Inflammatory Bowel Disease

Cited by 19 publications

References 47 publications

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel

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