Erythrocyte associated haemato-biochemical changes in Babesia equi infection experimentally produced in donkeys

Ambawat, H. K.; Malhotra, D.V.; Kumar, Sandeep; Dhar, S.

doi:10.1016/s0304-4017(99)00110-7

Cited by 41 publications

(33 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the negative correlation between percentage of parasitemia and PCV values in the current study may be due to destruction of B. ovis-infected erythrocytes. Similar findings have been reported by previous studies (Ambawat et al 1999, Bicek et al 2005, Crnogaj et al 2010). …”

Section: Discussionsupporting

confidence: 93%

“…Determination of MDA allows detection of the degree of lipid peroxidation and the level of free oxygen radicals indirectly (Deger et al 2009). Ambawat et al (1999) showed increased oxidative stress and a significant increase in lipid peroxidation in erythrocytes of cattle infected with Theileria equi. They concluded that this might be the cause of increased erythrocyte fragility due to membrane lysis.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Esmaeilnejad

Tavassoli

Asri‐Rezaei

et al. 2012

Acta Parasitologica

View full text Add to dashboard Cite

This study aimed to assess lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis. Red blood cell count (RBC), hemoglobin (Hb) concentration, packed cell volume (PCV), malondialdehyde (MDA) concentration, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities and total antioxidant capacity (TAC) were determined in 15 goats naturally infected with B. ovis as well as same number of healthy goats. The parasitological diagnosis was confirmed using polymerase chain reaction (PCR) analysis by amplifying a partial 18S rRNA gene sequence of B. ovis. Percentage of parasitemia varied from 0.01 to 1%. The activities of erythrocyte GSH-Px, SOD, CAT and TAC were significantly lower (p<0.05) in the infected goats than in healthy ones. MDA concentration in erythrocytes of infected goats was significantly higher in infected goats than in healthy ones (p<0.05). Severity of parasitemia showed a positive correlation with the MDA and negative correlation with PCV, SOD, CAT, GSH-Px and TAC. Also, MDA was negatively correlated with PCV, SOD, CAT, GSH-Px and TAC. The results of this study suggested that oxidative damage to RBCs may contribute to the pathogenesis of anemia in caprine babesiosis.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Esmaeilnejad

Tavassoli

Asri‐Rezaei

et al. 2012

Acta Parasitologica

View full text Add to dashboard Cite

show abstract

“…The enzymatic activity of Babesia-infected red blood cells increases in parallel with other metabolic activities as the invading organism develops [10,14]. Morphological and biochemical changes suggest that the erythrocyte's structure is altered in the acute phase of piroplasmosis, leading to hemolysis and anemia [27]. Among the important enzymes, carbonic anhydrase regulates the internal homeostasis of erythrocytes [28].…”

Section: Resultsmentioning

confidence: 99%

Plasma Levels of Zinc, Copper, Copper/Zinc Ratio, and Activity of Carbonic Anhydrase in Equine Piroplasmosis

Dede

Değer

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

We have determined the plasma concentrations of copper, zinc, copper/zinc ratio, and carbonic anhydrase activity in horses infected with Babesia equi. The study was conducted in 14 horses with the disease and 10 healthy animals that served as controls. The infection was confirmed by the clinical manifestations of the disease and by Giemsa staining of thin blood smears showing the parasites inside red blood cells. The horses with piroplasmosis had lower plasma levels of zinc, elevated copper, and increased activity of carbonic anhydrase. Consequently, the copper/zinc ratio was also higher than in the healthy controls.

show abstract

“…Disease condition caused by T. equi parasite is generally more pathogenic than by B. caballi, and during acute clinical infection in natural host, a significant increase in erythrocyte membrane protein, lipid, and plasma MDA has been observed, indicating marked alteration in biochemical composition of the infected erythrocytic membrane [17]. Lipid peroxidation contributes to pathogenesis of many parasitic diseases [18,19].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Damage Inflicted by Theileria equi on Horse Erythrocytes When Cultured In Vitro by Microaerophilous Stationary Phase Technique

Gopalakrishnan

Maji

Dahiya

et al. 2015

Journal of Equine Veterinary Science

View full text Add to dashboard Cite

Erythrocyte associated haemato-biochemical changes in Babesia equi infection experimentally produced in donkeys

Cited by 41 publications

References 6 publications

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Plasma Levels of Zinc, Copper, Copper/Zinc Ratio, and Activity of Carbonic Anhydrase in Equine Piroplasmosis

Oxidative Damage Inflicted by Theileria equi on Horse Erythrocytes When Cultured In Vitro by Microaerophilous Stationary Phase Technique

Contact Info

Product

Resources

About