Erythrocyte as a link between basic and clinical research

Saldanha, Carlota; Almeida, José Pedro

doi:10.3233/ch-2011-1496

Cited by 9 publications

(6 citation statements)

References 47 publications

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“… 9 There are many mechanical and physical factors that can affect the aggregation of red blood cells, and factors such as the inherent shape, deformability, and membrane surface substances of red blood cells are susceptible internal factors. 10 RDW is a measure of size changes (ie, anisocytosis) in circulating red blood cells, and high RDW refers to a great difference in sizes. 11 We detected a significant change in RDW from baseline in the thrombus group, which could be explained by the large variations in red blood cell volumes that increase blood viscosity and accelerate thrombus formation.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Red Cell Distribution Width in the Diagnosis of Peripherally Inserted Central Catheter (PICC)-Related Thrombosis Among Cancer Patients

Zhai¹,

Chen²,

Wang³

et al. 2023

IJGM

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Purpose This study aimed to investigate the predictive value of red cell distribution width (RDW) in patients with peripherally inserted central catheter (PICC)-related thrombosis. Patients and methods This was a case‒control study. A total of 98 cancer patients undergoing PICC placement from January 2017 to December 2019 at the ICU Venous Access Center of Peking University Cancer Hospital were retrospectively analyzed. These included 47 cases in the thrombosis group and 51 cases in the nonthrombosis group according to the occurrence of PICC-related thrombosis within 90 days after the PICC procedure. Results a) RDW was significantly higher in the thrombosis group (15.98±1.93) than in the nonthrombosis group (13.98±1.09). Additionally, the number of smoking histories in the thrombosis group (18, 38.30%) was significantly higher than that in the nonthrombosis group (5, 9.80%). b) Logistic regression analysis indicated that RDW and smoking history were independent risk factors for PICC-related thrombosis (OR: 3.028, P<0.001; OR: 5.640, P=0.023). c) The area under the receiver operating characteristic (ROC) curve of the combination of RDW and smoking history was 86.8%, and the sensitivity and specificity for predicting thrombosis after PICC were 85.1% and 80%, respectively. d) Cox regression analysis revealed that RDW and smoking history were independent risk factors for PICC-related thrombosis (p<0.001). e) Results from Kaplan‒Meier analysis showed that incidence of PICC-related thrombosis in patients with RDW less than 14.75% is significantly lower than those with RDW 14.75% and above (p<0.001). e) Baseline RDW was not different between the two groups (P>0.05), ΔRDW was significantly different between the two groups (p<0.001). Conclusion The combined use of RDW and smoking history has early evaluation and predictive value in the diagnosis of PICC-related thrombosis.

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Section: Discussionmentioning

confidence: 99%

Predictive Value of Red Cell Distribution Width in the Diagnosis of Peripherally Inserted Central Catheter (PICC)-Related Thrombosis Among Cancer Patients

Zhai¹,

Chen²,

Wang³

et al. 2023

IJGM

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“…The essential function of erythrocytes is to deliver O 2 to tissues by being highly deformable in order to pass through capillaries in the microcirculation ( Baskurt and Meiselman, 2003 ; Barshtein et al, 2007 ). Erythrocyte deformability modulated by shear stress serves as a compensating mechanism for maintaining adequate microcirculatory perfusion ( Saldanha and de Almeida, 2011 ). However, shear stress has a biphasic effect on the mechanical properties of erythrocytes depending on the duration and magnitude of the applied shear stress ( Nevaril et al, 1968 ; Meram et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Hsu

Lin

et al. 2022

Front. Physiol.

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Peripheral arterial disease (PAD) results in insufficient flow to lower extremities. Aerobic exercise provides health benefits for individuals with PAD, but basic science behind it is still debated. Twenty-one PAD patients aged about 70 years with female/male as 7/14 were recruited. Among them, 11 were randomized to have supervised cycling training (SCT) and 10 to receive general healthcare (GHC) as controls. SCT participants completed 36 sessions of SCT at the first ventilation threshold within 12 weeks and the controls received GHC for 12 weeks. Ankle-brachial index (ABI), 6-min walk test (6MWT), peak oxygen consumption (V˙O2peak), minute ventilation (V˙E), minute carbon dioxide production (V˙CO2), erythrocyte rheology, including the maximal elongation index (EImax) and shear stress at 50% of maximal elongation (SS1/2), and the Short Form-36 (SF-36) questionnaire for quality of life (QoL) were assessed before and 12 weeks after initial visit. SCT significantly decreased the SS1/2 as well as SS1/2 to EImax ratio (SS1/2/EImax) and increased the erythrocyte osmolality in the hypertonic region as well as the area under EI-osmolality curve. The supervised exercise-induced improvement of erythrocyte deformability could contribute to the increased peripheral tissue O2 delivery and was possibly related with increased V˙O2peak. The physiological benefit was associated with significantly increased ABI, 6-min walking distance, cardiorespiratory fitness, and SF-36 score. However, no significant changes in aerobic capacity and erythrocyte rheological properties were observed after 12-week of GHC. In conclusion, SCT improves aerobic capacity by enhancing erythrocyte membrane deformability and consequently promotes QoL in PAD patients.

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“…Hemorheology is the science which studies blood deformation and its components' interaction with vessel walls, occurring inside blood vessels of macro and microcirculation. In the past, the longitudinal and follow-up clinical studies done, ex vivo, have as an objective the characterization of the intravascular profile of different diseases according to hemorheological parameters and inflammatory factors [41,48,59]. To accomplish this aim, blood samples were taken from patients with acute myocardial infarction, glaucoma, Bechet, renal diseases whether submitted or not to chronic hemodialysis or kidney transplant and diabetic retinopathy degree, and an association between the laboratorial data and the clinical parameter values was observed [41,48,59].…”

Section: Ex Vivomentioning

confidence: 99%

Erythrocyte Nitric Oxide

Saldanha¹,

Silva-Herdade²

2018

Novel Prospects in Oxidative and Nitrosative Stress

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Nitric oxide (NO) is a vasoactive molecule that, by stimulated and functional vascular endothelial cells, is released to the lumen of the vessel and into the surrounding smooth muscle cells. Once in the lumen, NO is captured by red blood cells and scavenged inside through hemoglobin and derived as NO metabolites. The delivery ability of erythrocytes allowing the NO efflux also occurs. Manipulation of NO levels inside the erythrocyte through different external (acetylcholine, acetylcholinesterase inhibitors, fibrinogen and CD47 4N1K peptide) and internal (redox and protein phosphorylation levels) stimuli will be described. The values of NO efflux from the erythrocytes and its association with the data quantified in the hemorheology properties and in clinical parameters obtained from patients with vascular diseases will also be present. The in vivo animal experimental studies highlighting the ability of NO efflux (delivered) from the erythrocytes where is scavenged and its influence in inflammatory and hemorheological responses will be addressed. So, the aim of this chapter is to present the knowledge obtained about the NO signal transduction mechanism in erythrocytes and the association between erythrocyte availability in NO with clinical biomarkers obtained in inflammatory vascular diseases. A final question is raised-namely, could NO be considered a hemorheological parameter?

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Erythrocyte as a link between basic and clinical research

Cited by 9 publications

References 47 publications

Predictive Value of Red Cell Distribution Width in the Diagnosis of Peripherally Inserted Central Catheter (PICC)-Related Thrombosis Among Cancer Patients

Predictive Value of Red Cell Distribution Width in the Diagnosis of Peripherally Inserted Central Catheter (PICC)-Related Thrombosis Among Cancer Patients

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Erythrocyte Nitric Oxide

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