Erythrocyte antioxidant defense response against cigarette smoking in humans—the glutathione S‐transferase vulnerability

Orhan, Hilmi; Evelo, Chris T.; Şahin, Gönül

doi:10.1002/jbt.20088

Cited by 44 publications

(40 citation statements)

References 33 publications

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“…Guentsch et al (23) and Akalın et al (24) reported that MDA levels increased in the saliva of smokers versus nonsmokers and these findings were in concordance with those reported by some previous studies in venous blood erythrocyte/serum/plasma (22,(25)(26)(27). Our findings support these results.…”

Section: Discussionsupporting

confidence: 93%

A comparison of the generation of free radicals in saliva of active and passive smokers

Demirtaş¹,

Şenel²,

Yüksel³

et al. 2014

Turk J Med Sci

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The erosion/incision patterns of radiometrically well-constrained volcanic rocks provide excellent markers for revealing the landscape evolution. The Central Anatolian High Plateau represents an uplifted area that reaches up to 1500 m above sea level and includes the Cappadocian Volcanic Province (CVP). The CVP is composed of horizontally emplaced Neogene-Quaternary ignimbrites intercalated with lava flows and epiclastic continental sediments. River incision rates have been calculated using the morphological/ paleoaltimetric features of radiometrically well-constrained volcanic units in the area. Starting from 10 Ma until 5 Ma, there was no major erosion or incision. The morphology, uplift rate, and incision rates of the CVP reveal that the onset of uplift is post 8 Ma and incision started after 5 Ma. Between 5 and 2.5 Ma, the incision rate is computed as 0.12 mm/year, whereas, in the last 2.5 Ma, the incision rate slowed down to 0.04 mm/year.

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Section: Discussionsupporting

confidence: 93%

A comparison of the generation of free radicals in saliva of active and passive smokers

Demirtaş¹,

Şenel²,

Yüksel³

et al. 2014

Turk J Med Sci

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“…Among the present controls, catalase activity was significantly higher in ex-smokers than in current smokers. Although healthy smoking controls may also be subjected to oxidative stress, they do not have COPD and might not exhibit the compensatory increase in erythrocyte catalase activity, which is supported by previous reports [27,28].…”

Section: Discussionsupporting

confidence: 80%

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Mak

Ho²,

Yu³

et al. 2007

European Respiratory Journal

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Increased oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the risk of COPD and the substitution of alanine 16 with valine (Ala16Val) polymorphism of manganese-superoxide dismutase (Mn-SOD) and the cytosine to thymidine transition of nucleotide -262 (-262C.T) polymorphism of the catalase gene, and the activity of erythrocyte SOD and catalase.The subjects were stable COPD patient ever smokers (n5165) and healthy controls, matched for age and cigarette consumption. Genotyping of Mn-SOD at Ala16Val and the catalase gene at -262C.T was performed, and the functional activity of SOD and catalase in erythrocytes determined.There were no significant differences in the distribution of the different genotypes or allele frequencies between patients and controls for both the Mn-SOD and catalase genes. Among healthy controls or COPD patients, no differences were observed in erythrocyte SOD and catalase activity, irrespective of genotype. Significantly higher erythrocyte catalase activity was found in COPD patients than in healthy controls. The T/T catalase genotype and Ala/Ala Mn-SOD genotype were uncommon in the present Chinese population.The increase in erythrocyte catalase activity in Chinese patients with chronic obstructive pulmonary disease probably indicates dysfunction of the oxidant/antioxidant defence system, but it is unclear whether this increase is compensatory or a pathogenic factor.

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“…Hence it is suggested that there may be a strong association of GST with lung function at the molecular level [44][45][46][47][48]. Interestingly, in this investigation, we also found GST activity was not only lower in COPD but also progressively decreased with the severity of COPD disease.…”

Section: Discussionsupporting

confidence: 67%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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Background: Oxidative stress has been suggested in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) with an additional burden of diabetes, hypertension and cardiovascular disease. In the present study, we investigated erythrocyte antioxidant enzymes activities in correlation to COPD severity and COPD comorbidities. Methods: One hundred twenty seven subjects with COPD and 59 healthy controls participated in this study. COPD severity was done based on the Global Initiative for Chronic Obstructive Lung Disease criteria. The erythrocytes enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS) were measured with spectrophotometric method. Results: COPD patients showed significant decrease in TAS (p > 0.05), GST (p < 0.001) and GPx (p < 0.01) activities with progression of the disease. In patients, FEV 1 was negatively correlated with SOD, GR and positively correlated with GST and GPx activities. Further, multivariate logistic regression analysis revealed GST (OR = 0.93; 95% CI = -0.10 -0.01; p < 0.01) , GPx (OR = 0.98; 95% CI = -0.03 -0.00; p < 0.05) and TAS (OR = 0.95; 95% CI = -0.08 -0.00; p < 0.05) were independently associated with FEV 1 in GOLD stage IV and GST (OR = 1.11; 95% CI = 0.04-0.18; p < 0.001) in GOLD stage II. Regression analysis confirmed a significant difference in GPx activity in COPD -type 2 diabetes (OR = 0.04; 95% CI = -6.60 -0.53; P = 0.09), and GST activity in COPD -cardiovascular disease (OR = 2.51; 95% CI = 0.00 -1.84; p < 0.05) patients when compared to patients without comorbidities. Conclusion: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between GST and GPx with COPD severity. Our results also indicate that erythrocytes GST and GPX activities are significantly associated with comorbidities, but only in COPD patients with type 2 diabetes and cardiovascular disease.

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Erythrocyte antioxidant defense response against cigarette smoking in humans—the glutathione S‐transferase vulnerability

Cited by 44 publications

References 33 publications

A comparison of the generation of free radicals in saliva of active and passive smokers

A comparison of the generation of free radicals in saliva of active and passive smokers

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

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