Erythrocyte and dietary zinc in adolescent females

Kenney, Mary Alice; Ritchey, S. J.; Culley, P; Sandoval, Wendy M.; Moak, S. W.; Schilling, P. E.

doi:10.1093/ajcn/39.3.446

Cited by 15 publications

(8 citation statements)

References 16 publications

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“…Mean RBC zinc was low (58 mg/g of packed cells) in 23.6% girls (Kenney et al, 1984). Prevalence of anemia (hemoglobin 512 g/ dl) was 26.1%.…”

Section: Resultsmentioning

confidence: 93%

“…PZ was estimated by the wet digestion method using three acid mixture (HNO3:HClO4: H2SO4 in 3:2:1 proportion) and deionised distilled water as per the manual of National Institute of Nutrition, India (Raghuramulu et al, 2003) using atomic absorption spectrometer (AAS) (Perkin Elmer Model 3110, Waltham, MA) with a specific cathode lamp. Erythrocyte (RBC) zinc was measured as per the method by Kenney et al (1984). Weighed aliquots of red cells (0.5 to 1 g) were digested with the similar acid mixture and diluted with deionized water to estimate zinc by AAS.…”

Section: Biomarkers Of Zinc and Ironmentioning

confidence: 99%

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Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls

Chiplonkar

Kawade²

2014

International Journal of Food Sciences and Nutrition

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A cross-sectional study (n = 403) was conducted to examine the relationship of plasma zinc (PZ) and erythrocyte zinc (EZ) levels with cognitive performance and taste acuity for salt in Indian adolescent girls. PZ, EZ and hemoglobin were estimated in schoolgirls (10-16 years). Cognitive performance was assessed by simple-reaction-time (SRT), recognition-reaction-time (RRT), visual-memory, Raven's Progressive Matrices (RPM) test. Taste acuity was determined by recognition-thresholds-for-salt (RTS) using 10 different salt concentrations. Low PZ (<0.7 mg/l) and EZ (<8 µg/g of packed cells) were observed in 72% and 23.6% of girls, respectively. PZ and EZ were negatively associated with SRT (r = -0.41, -0.34), RRT (r = -0.49, -0.4), and positively with Memory (r = 0.43, 0.34) and RPM (r = 0.39, 0.31; p < 0.05) and remained significant after adjusting for socio-demographic factors and hemoglobin. RTS was impaired in 18.3% girls and significantly correlated with EZ (r = -0.31, p < 0.05). Zinc deficiency in adolescent girls was associated with poor cognition and taste function implying need for improving their dietary zinc intakes.

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“…Mean RBC zinc was low (58 mg/g of packed cells) in 23.6% girls (Kenney et al, 1984). Prevalence of anemia (hemoglobin 512 g/ dl) was 26.1%.…”

Section: Resultsmentioning

confidence: 93%

Section: Biomarkers Of Zinc and Ironmentioning

confidence: 99%

Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls

Chiplonkar

Kawade²

2014

International Journal of Food Sciences and Nutrition

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“…Plasma zinc levels were low (<0.7 mg/l) (41) in 72.4%, and erythrocyte zinc levels were low (<8 µg/g of packed cells) (56) in 23.6% of the girls. Prevalence of anemia (Hb < 12 g/dl) was 27.2%, and 26.6% girls had low serum ferritin lpar; (<12 µg/l) (67).…”

Section: Resultsmentioning

confidence: 99%

“…Serum ferritin was estimated by Fully Automated Bidirectionally Interfaced Chemi Luminescent Immuno Assay. Plasma levels of zinc, vitamin C, β-carotene and retinol were measured as per the methods in the manual by National Institute of Nutrition, India (55), and erythrocyte zinc was measured as per the method described by Kenny et al (56). Reference serum (RANDOX Laboratories, India) was used as a standard for blood estimations.…”

Section: Methodsmentioning

confidence: 99%

Zinc status and its association with the health of adolescents: a review of studies in India

Kawade

2012

Global Health Action

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BackgroundZinc is important in adolescence because of its role in growth and sexual maturation. Adolescents from developing countries such as India may be at high risk of zinc deficiency because of unwholesome food habits and poor bioavailability of zinc from plant-based diets.Objective(1) to study zinc status and its association with profile of other micronutrients, (2) to construct a simple tool in the form of Adolescent Micronutrient Quality Index (AMQI) to assess quality of diets of the girls and (3) to examine the effect of zinc supplement on health of adolescent girls.MethodsGirls (10–16 years) from two secondary schools of Pune, Maharashtra state, in Western India were enrolled in a cross-sectional study (n = 630). Data were collected on dietary intake, cognitive performance, taste acuity, haemoglobin, erythrocyte zinc and plasma levels of zinc, vitamin C, β-carotene and retinol. AMQI was developed using age–sex-specific Indian dietary guidelines and healthy foods and habits described in the recent US dietary guidelines. Zinc-rich recipes were developed considering habitual diets of the girls and vegetarian sources of zinc. An intervention trial (n = 180) was conducted to assess the effect of zinc-rich dietary supplements and ayurvedic zinc (Jasad) supplementation.ResultsPrevalence of micronutrient deficiencies was high in these girls. Poor cognitive performance was seen in half of the girls, and salt taste perception was affected in 45%. AMQI was correlated with nutrient intakes and blood micronutrient levels (p < 0.01), indicating the potential of AMQI to measure micronutrient quality of diets of adolescent girls. Results of the intervention trial indicated that supplementation of zinc-rich recipes vis-a-vis ayurvedic Jasad zinc has the potential to improve plasma zinc status, cognitive performance and taste acuity in adolescent girls.ConclusionsReview of the studies on Indian adolescent girls demonstrates the necessity of adopting zinc and micronutrient-rich diets for positive health building in adolescents.

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“…Hemoglobin concentration was measured using the cyanmethhemoglobin method. Erythrocyte lysate was diluted 10 fold with milli-Q water; zinc and copper concentrations were determined by flame atomic absorption spectrophotometry (3110, Perkin Elmer, Waltham, MA, USA) 13,14 and values were expressed as micrograms of zinc per g of hemoglobin. Stool samples of chronic pancreatitis patients were collected and stored at -4°C for less than one week prior to use.…”

Section: Data Recordingmentioning

confidence: 99%

Zinc/copper ratio: a predictor of pancreatic function in chronic pancreatitis?

BN¹

2016

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Background: The role of trace elements in the maintenance of normal pancreatic function is unclear. Aim: To estimate trace elements (zinc and copper) in chronic pancreatitis (CP) patients and study their relationship with exocrine and endocrine insufficiency. Methods: The study involved 101 CP patients and 113 healthy controls. Disease characteristics and imaging features were recorded. Erythrocyte zinc (Zn) and copper (Cu) were estimated by flame atomic absorption spectrophotometry. Fecal pancreatic elastase1 was estimated by polyclonal antibody ELISA method as a marker of pancreatic exocrine function. Results: The mean erythrocyte Zn level and Zn/Cu ratio were significantly lower whereas the copper level was significantly higher in CP patients than controls. The mean Zn level and Zn/Cu ratio was significantly lower in CP patients with diabetes and those with low elastase1 as compared to non-diabetics and those with normal elastase1 respectively. Erythrocyte Cu level was significantly higher in CP patients with diabetes and with low elastase1 than those without diabetes and with normal elastase1 levels respectively. There was a significant positive correlation between elastase1 and Zn/Cu ratio (r = 0.396, p < 0.001). Receiver operating characteristic curve (ROC) analysis was performed to predict the development of exocrine insufficiency and it indicated an area under curve (AUC) of 0.838 ± 0.047 (95% CI: 0.746-0.93). The optimal cutoff value was 9.03 (sensitivity 86.5%, specificity 73.5%). When the same was performed to predict the development of diabetes, the AUC was 0.710 ± 0.05 (95% CI: 0.607-0.812). The optimal cutoff value was 7.2 (sensitivity 69.1%, specificity 69.7%). Conclusion: Low erythrocyte Zn/Cu ratio was found to be associated with exocrine and endocrine insufficiency in CP patients.

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Erythrocyte and dietary zinc in adolescent females

Cited by 15 publications

References 16 publications

Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls

Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls

Zinc status and its association with the health of adolescents: a review of studies in India

Zinc/copper ratio: a predictor of pancreatic function in chronic pancreatitis?

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