Erythroblastic Anemia

Abstract

Further observation and experience with erythroblastic anemia have strengthened our conviction that it is a definite clinical entity, and, to judge from our own experience and reports, verbal and published, from other clinics, not rare in children of Mediterranean ancestry, especially the Greeks. We are glad to have our position fortified by the careful studies of Baty, Blackfan and Diamond. Their paper is so complete and so thoroughly in accord with our present ideas that there seems to be no occasion for us to go over the whole ground in presenting at this time a few corrections of our original presentation and some additional observations. NUMBER OF CASES AND RACIAL INCIDENCEOur first report1 comprised seven cases, five of which were from our clinic, one from Abt's and one from Blackfan's. All of the patients were of the Mediterranean races except the patients in cases 4 and 7 from our clinic. These two were the least characteristic of the group,

Malaria: Genetic and Evolutionary Aspects

“…In 1932, when George Whipple suggested the term "thalassemia" Bradford, 1932, 1936), Thomas Cooley noticed that the disease he had clinically defined showed a clear familial incidence (Cooley and Lee, 1932). Later, Heinrich Lehndorf proposed that Cooley's anemia was an inherited disease due to a genetic mutation (Lehndorf, 1936).…”

Observations on Haemolytic Disease

“…During the period of these discoveries Cooley and Lee (1925) described an anaemia characterised by "target" cells in the blood, splenomegaly and skeletal changes. They considered the anaemia to be of haemolytic type (Cooley, Witwer and Lee 1927) but were also concerned with the obvious defects in haemopoiesis (Cooley and Lee 1932) which is now regarded as the more important factor.…”

Erythroblastic anaemia with bone changes in Egyptian children: Possible Cooley's Type

“…Although most of the reported cases occurred in children of Mediterranean stock, Cooley and Lee (1932) believe that no great stress should be laid on the limitation of this or any other similar disease to a particular race. Cases have been reported in an English child by Bywaters (1938), in a Chinese girl by Foster (1940), and in a Hindu child by Mukherji (1938).…”