Erythematous generalized granuloma annulare

Eng, A. M.

doi:10.1001/archderm.115.10.1210

Cited by 7 publications

(2 citation statements)

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“…Anetoderma has been reported to arise within the site of resolving generalized GA lesions. 5,6,9,18,19,[24][25][26] Deeper tissue involvement of generalized GA can cause severe deformities including destructive arthritis and infiltrative edema of the affected limb, with granulomatous involvement of the deep fascia, tendons, bones, and joints, resulting in progressive joint narrowing, ankylosis, and erosions of bone with resorption. 3 Patients with generalized GA are reported to have an increased incidence of human leukocyte antigen (HLA)-A31 and HLA-Bw35 MHC groups, while patients with localized GA have HLA profiles that are similar to controls.…”

Section: Etiologymentioning

confidence: 99%

Collagenolytic (necrobiotic) granulomas: part 1 – the ‘blue’ granulomas

Lynch

Barrett

2004

J Cutan Pathol

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A collagenolytic or necrobiotic non-infectious granuloma is one in which a granulomatous infiltrate develops around a central area of altered collagen and elastic fibers. The altered fibers lose their distinct boundaries and exhibit new staining patterns, becoming either more basophilic or eosinophilic. Within the area of altered collagen, there may be deposition of acellular substances such as mucin (blue) or fibrin (red), or there may be neutrophils with nuclear dust (blue), eosinophils (red), or flame figures (red). These color distinctions can be used as a simple algorithm for the diagnosis of collagenolytic granulomas, i.e. 'blue' granulomas vs. 'red' granulomas. Eight diagnoses are included within these two groupings, which are discussed in this two-part article. In this first part, the clinical presentation, pathogenesis, and histologic features of the 'blue' collagenolytic granulomas are discussed. These are the lesions of granuloma annulare, Wegener's granulomatosis, and rheumatoid vasculitis. In the subsequent half of this two-part series, the 'red' collagenolytic granulomas will be discussed; these are the lesions of necrobiosis lipoidica, necrobiotic xanthogranuloma, rheumatoid nodules, Churg-Strauss syndrome, and eosinophilic cellulitis (Well's syndrome).Lynch JM, Barrett TL. Collagenolytic (necrobiotic) granulomas: part 1 -the 'blue' granulomas.

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Section: Etiologymentioning

confidence: 99%

Collagenolytic (necrobiotic) granulomas: part 1 – the ‘blue’ granulomas

Lynch

Barrett

2004

J Cutan Pathol

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“…Granuloma anntilare is a disease of unknown etiology and clinically is characterized by erythematous to violaceous dome-shaped papules frequently arranged in annular configurations. Varied clinical varieties have been described including generalized erythematous lesions (5), perforating lesions (6), perforating transfollicular types (7), and nodular subcutaneous varieties (8,9,10). The subcutaneous variety has been reported to occur often in infants and children, and frequently to have been located on the extremities and scalp.…”

Section: Granuloma Annularementioning

confidence: 99%