Erythematous Eruption With Marked Conjunctival Injection—Quiz Case

Kaminska, Edidiong Celestine Ntuen; Yu, Zoey; Kress, John P.; Petronic‐Rosic, Vesna; Soltani, Keyoumars

doi:10.1001/archderm.148.10.1199-d

Cited by 3 publications

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“…Around 25-30% of T-PLL patients develop cutaneous involvement, typically at presentation [81][82][83][84]. Although the skin lesions mainly present as retiform hyperpigmented macules and patches, they can also be found as skin nodules, erythroderma, symmetrical distributed petechia or purpura, and facial eruptions (Figure 3) [82,83,85,86]. In some cases, conjunctival involvement has been reported with periorbital petechiae (Figure 3) [83,85,87,88].…”

Section: T Cell Prolymphocytic Leukemiamentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.

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Section: T Cell Prolymphocytic Leukemiamentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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“…Cutaneous involvement is a common symptom of T-PLL, and appears in 25-30% of patients, most commonly at presentation [80][81][82][83]. Skin lesions present mainly as retiform hyperpigmented macules and patches; however they can also be found as skin nodules, erythroderma, symmetrical distributed petechia or purpura and facial eruption (Figure 3) [81,82,84,85]. Conjunctival involvement and periorbital petechiae have also been reported in some patients with T-PLL (Figure 3) [82,84,86,87].…”

Section: T Cell Prolymphocytic Leukemiamentioning

confidence: 99%

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

Robak,

Braun,

Robak

2023

Preprint

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Leukemia cutis (LC) is defined as leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and in T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis and treatment of leukemic skin involvement in different types of leukemia

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Pathology of T-Cell Lymphomas: Diagnosis and Biomarker Discovery

Gru

2015

Non-Hodgkin Lymphoma

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T-cell lymphomas are a group of predominantly rare hematologic malignancies that tend to recapitulate different stages of T-cell development, in a similar way that B-cell lymphomas do. As opposed to B-cell lymphomas, the understanding of the biology and the classification of T-cell lymphomas are somewhat rudimentary, and numerous entities are still included as 'provisional categories' in the World Health Classification of hematolopoietic malignancies. A relevant and useful classification of these disorders have been difficult to accomplish because of the rarity nature of them, the relative lack of understanding of the molecular pathogenesis, and their morphological and immunophenotypical complexity. Overall, T-cell lymphomas represent only 15 % of all non-Hodgkin lymphomas. This review is focused on addressing the current status of the categories of mature T-cell leukemias and lymphomas (nodal and extranodal) using an approach that incorporates histopathology, immunophenotype, and molecular understanding of the nature of these disorders, using the same philosophy of the most recent revised WHO classification of hematopoietic malignancies.

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Erythematous Eruption With Marked Conjunctival Injection—Quiz Case

Cited by 3 publications

References 0 publications

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

Pathology of T-Cell Lymphomas: Diagnosis and Biomarker Discovery

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