Erythemal Ultraviolet Exposure of Cyclists in Valencia, Spain

Serrano, María-Antonia; Cañada, J.; Moreno, Juan Carlos

doi:10.1111/j.1751-1097.2009.00693.x

Cited by 29 publications

(36 citation statements)

References 20 publications

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“…Direct terrestrial measurements at these latitudes indicate that under summer sunlight conditions on clear days in Northern or Southern Hemisphere between 11 AM and 3 PM one can measure SED’s in the range of 10 to 20 depending on exposure conditions. As an example and as part of a project to estimate the number of SED’s one might receive during the day using, in this case, cyclists training in Spain during summer and winter, a recent paper by Serrano et al shows just such levels in good agreement with our measurements35.…”

Section: Methodssupporting

confidence: 86%

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Zaidi

Davis

Noonan

et al. 2011

Nature

266

299

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Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, whose incidence continues to rise. Epidemiological studies reveal that the major etiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especially during childhood1,2. We have experimentally validated these epidemiological findings using the hepatocyte growth factor/scatter factor (HGF/SF) transgenic mouse model, which develops lesions in stages highly reminiscent of human melanoma with respect to biological, genetic and etiologic criteria, but only when irradiated as neonatal pups with UVB, not UVA3,4. However, mechanisms underlying UVB-initiated, neonatal-specific melanomagenesis remain largely unknown. Here we introduce a mouse model permitting fluorescence-aided melanocyte imaging and isolation following in vivo UV irradiation. We use expression profiling to show that activated neonatal skin melanocytes isolated following a melanomagenic UVB dose bear a distinct, persistent interferon response signature, including genes associated with immunoevasion. UVB-induced melanocyte activation, characterized by aberrant growth and migration, was abolished by antibody-mediated systemic blockade of interferon-γ (IFN-γ), but not type-I interferons. IFN-γ was produced by macrophages recruited to neonatal skin by UVB-induced ligands to the chemokine receptor Ccr2. Admixed recruited skin macrophages enhanced transplanted melanoma growth by inhibiting apoptosis; notably, IFN-γ blockade abolished macrophage-enhanced melanoma growth and survival. IFN-γ-producing macrophages were also identified in 70% of human melanomas examined. Our data reveal an unanticipated role for IFN-γ in promoting melanocytic cell survival/immunoevasion, and suggest that IFN-γ-R signaling represents a novel therapeutic melanoma target.

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Section: Methodssupporting

confidence: 86%

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Zaidi

Davis

Noonan

et al. 2011

Nature

266

299

View full text Add to dashboard Cite

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“…These dosimeters have been used effectively for personal UV measurements in outdoor occupations, 25,33 and in recreational activities. [28][29][30] Details of the production and development of the spore films (containing DNA molecules of Bacillus subtilis) can be found at Furusawa et al 34 and Munakata et al.…”

Section: Personal Uv Dosimetersmentioning

confidence: 99%

“…Mountaineering and cycling are among the outdoor recreational activities with the highest measured UV exposure and the largest number of studies. [25][26][27][28][29][30][31] However, there are few studies on the UV exposure of runners 28 and tennis players 28,31 while performing their sport.…”

mentioning

confidence: 99%

Personal UV exposure for different outdoor sports

Serrano

Cañada

Moreno

et al. 2014

Photochem Photobiol Sci

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The aim of this paper is to measure UV exposure for three groups of amateur athletes in their training/recreational schedules, using VioSpor personal dosimeters and we found that two of these groups exceeded the international UV threshold level for non sun-adapted Mediterranean skin.. . AbstractExposure to ultraviolet (UV) radiation is the major environmental risk factor in the development of skin cancers and it occurs mainly during outdoor activities. The purpose of this study is to quantify the UV exposure suffered by amateur athletes (tennis players, hikers and runners) in their training schedules. The study on tennis player exposure took place at a tennis club in Valencia during the month of June 2011. With respect to the hiking group, the hikes studied took place in several mountainous areas of Spain andFrance from June to August 2011. Finally, the exposure suffered by ten runners, while participating in a running circuit in the province of Valencia, from March to November 2011, was studied. The athletes were monitored using personal dosimeters (VioSpor), with the tennis players and runners wearing them on the wrist, and the hikers on the shoulder. The median daily personal UV exposure for the hikers was 8.1 Standard Erythema Dose (SED), and for the tennis players 7.5 SED, per day of training. The runners received a median of 14.6 SED while participating in the running circuit, and about 2 SED per competition day. Median daily UV exposure of the hikers and tennis players exceeded 5 SED, which means that, in the case of non sun-adapted skin type III and the non-use of sun protection, erythema may be induced in these subjects. However, the exposure suffered by the runners did not exceed the maximum personal exposure of 5 SED. Accordingly, it is necessary to encourage the use of high protection sunscreens and protective clothing, and to avoid UV exposure in the hottest part of the day.

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“…Dosimeters can be used effectively for personal UV measurements in outdoor occupations (Moehrle and Garbe 2000;Serrano et al 2009), recreational activities ( Moehrle and Garbe 2000;Thieden et al 2000;Serrano et al 2010), and school activities (Boldeman et al 2004;Ono et al 2005;Serrano et al 2011). They are easy to place and manage; and have a spectral sensivity profile similar to erythema-weighted data calculated from spectral measurements.…”

Section: Introductionmentioning

confidence: 99%

Solar UV exposure of children in a summer school in Valencia, Spain

2011

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Ultraviolet (UV) exposure is the major environmental factor involved in the development of skin cancers and occurs mainly during outdoor activities. During summer schools, children receive regular and significant solar ultraviolet erythemal radiation (UVER) while practicing outdoor activities. Personal dosimeters (VioSpor) were attached to the shoulders of schoolchildren and used to quantify their exposure to UVER. The study took place in Valencia, Spain, during July 2008, with three age groups (7-8, 9-10 and 11-12 year-olds) and involved about 15 schoolchildren. The median (25, 75 percentile) two-daily UV exposure values for all groups was 5.49 (3.59, 8.00) standard erythemal doses (SEDs), where 1 SED is defined as effective 100 Jm -2 when weighted with the CIE erythemal response function. Exposure ratio (ER) is defined as the ratio between the personal dose on a selected body site and the corresponding ambient dose received on a horizontal plane during the same exposure period.The median (25, 75 percentile) ER value for all groups in the study was 5.9 (4.1, 8.7) %.

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Erythemal Ultraviolet Exposure of Cyclists in Valencia, Spain

Cited by 29 publications

References 20 publications

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Personal UV exposure for different outdoor sports

Solar UV exposure of children in a summer school in Valencia, Spain

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