Erythema Palmare Hereditarium (Red Palms)

Sarcoidosis presenting as palmar erythema

“…This feature is commonly seen in pregnancy and liver disease but may also occur in other diseases, particularly rheumatoid arthritis 9 . Palmar erythema in isolation has also been described, occurring as an inherited disorder with an autosomal dominant pattern, 10 but sarcoidosis presenting in such a way has not to our knowledge been previously reported. We now believe that clinicians should consider sarcoidosis in the differential diagnosis of all patients presenting with palmar erythema, and if clinically indicated, skin biopsy will then help confirm the diagnosis.…”

Lane's Disease (Erythema Palmare Hereditarium): A Report of Five Cases and a Review of the Literature

“…Lane first described EPH in 1929 , reporting two cases, a 51‐year‐old man and a 69‐year‐old man who presented with red palms. A family history of palmar redness was reported in both patients.…”

“…Erythema palmare hereditarium (EPH), also known as Lane's disease (Online Mendelian Inheritance in Man 133000), is a rare, benign condition presenting as persistent erythema involving the palms. EPH can appear at birth or later in life and usually in at least two otherwise healthy members of the same family, although a sporadic case has been reported .…”

Erythema Palmare Hereditarium (‘Red Palms', ‘Lane's Disease')

“…Erythema palmare hereditarium, also known under the names of ‘red palms’ or ‘Lane's disease’, was described for the first time by John E. Lane in 1929 [ 1 ]. In contrast to the cases which have been published up to now, there is no further affected relative in our patient's family, concluding that the mutation has to be spontaneous.…”

“…Further differential diagnoses would have been chronic polyarthritis, collagenosis and endocrine functional pathologies [ 3 ], none of them being identified for the patient given. With the exception of an operated cervical stenosis, the patient does not have any physical complaints and hence can be compared to one of Lane's patients [ 1 ]. The diagnosis of erythema palmare symptomaticum was excluded, despite 30 pack-years of nicotine abuse, because the erythema has been persisting unchanged since the woman's birth, independent of external factors like physical activity [ 4 ].…”