“…They are thought to develop due to a loss of tolerance to self‐antigens which may consequently lead to organ toxicities (Brahmer et al, ; Chen & Han, ; Topalian et al, ). While all organs may be affected, more commonly reported irAEs include dermatological (lichenoid eruptions, vitiligo), gastrointestinal (diarrhea, hepatitis), endocrine (thyroiditis), pulmonary (pneumonitis), and renal (nephritis) (Belli et al, ; De Velasco et al, ; Hofmann et al, ; Michot et al, ; Ohtsuka, Miura, Mori, Ishikawa, & Yamamoto, ; Tetzlaff et al, ). When sufficiently severe, irAEs may require dose modification or suspension of treatment, which may lead to unfavorable outcomes and a negative impact on survival (Rapoport et al, ; Wang et al, ).…”