Erythema multiforme (“Minus” and “Maius”) and drug intake

Fabbri, Paolo; Panconesi, E

doi:10.1016/0738-081x(93)90154-5

Cited by 29 publications

(33 citation statements)

References 105 publications

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“…Studies from our and other laboratories have shown that the viral DNA fragments are retained in HAEM lesional skin, which expresses the viral gene Pol. Pol expression and the accumulation of restricted populations of virus-specific Th1 cells are early events in HAEM lesion development [1, 9]. These are followed by a longer and non-virus-specific inflammatory response [4].…”

Section: Discussionmentioning

confidence: 99%

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The Herpes Simplex Virus Gene Pol Expressed in Herpes-Associated Erythema Multiforme Lesions Upregulates/Activates SP1 and Inflammatory Cytokines

et al. 2007

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Background/Aims: Herpes-simplex-virus-associated erythema multiforme (HAEM) is characterized by lesional skin expression of the viral protein Pol and localized inflammation. The objective of this study is to examine the mechanism whereby Pol induces localized inflammation. Methods: A431 cells transfected with Pol or an empty vector and lesional skin from HAEM or drug-induced erythema multiforme patients were examined for expression of the transcription factor SP1 and SP1-regulated genes by immunoblotting, immunohistochemistry and immunofluorescence. Results: SP1, TGF-β, p21^waf1 and Hsp27 were upregulated in A431 cells transfected with Pol but not the empty vector. Expression was further increased by exposure to IFN-γ. Pol+ HAEM lesional skin expressed SP1, Hsp27, TGF-β and p21^waf1. Normal skin and drug-induced erythema multiforme lesional skin were negative. Conclusion: The data indicate that Pol activates SP1, causing upregulation of SP1 target genes (notably TGF-β) involved in localized inflammation. Upregulation is potentiated by IFN-γ.

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Section: Discussionmentioning

confidence: 99%

“…It can follow administration of several drugs [drug-induced erythema multiforme (DIEM)] [1,2,3] or various infections, including recurrent episodes of herpes simplex virus (HSV) [HSV-associated erythema multiforme (HAEM)] [4]. Clinically, HAEM and DIEM overlap.…”

Section: Introductionmentioning

confidence: 99%

The Herpes Simplex Virus Gene Pol Expressed in Herpes-Associated Erythema Multiforme Lesions Upregulates/Activates SP1 and Inflammatory Cytokines

et al. 2007

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“…Less well-documented associations include immunizations, neoplasms, connective tissue disease, physical agents, food and inhalants [2]. The best-documented drug association is the one with sulfonamides.…”

Section: Discussionmentioning

confidence: 99%

“…The great variation in clinical presentation has given rise to several clinical syndromes, such as Stevens-Johnson, Fuchs syndromes or toxic epidermal necrolysis, that probably share a common pathophysiological pathway. Mainly infections with herpes simplex virus and mycoplasma as well as drugs are believed to trigger the typical skin changes [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

Cocaine-Related Stevens-Johnson Syndrome

Hofbauer

Burg

Nestle³

2000

Dermatology

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We report the case of a 26-year-old student with erosive skin changes on his oral and genital mucosa and skin as well as on his thighs twice after cocaine snorting. The second of these two episodes was documented histologically, and other underlying causes of disease were excluded. A diagnosis of recurring Stevens-Johnson syndrome was made. Treatment was initiated with bed rest, systemic prednisone at 1 mg/kg body weight and liquid nutrition. Mucosal changes resolved within 4 days. On follow-up the patient remained free of symptoms while abstaining from the particular cocaine street mix in question. Cocaine has been involved in seizures, headaches, ischemic strokes, intracerebral hemorrhage, cerebral vasculitis, Churg-Strauss vasculitis, palpable purpura and Henoch-Schönlein vasculitis. Bullous skin disease in association with cocaine has been reported in 1 patient. To our knowledge, we report the first case of Stevens-Johnson syndrome associated with cocaine snorting.

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“…s , 6 Most mucocutaneous lesions tend to heal completely in 2 to 6 weeks, and fatal forms are exceptional (1 percent of cases in one series). 5,7 Toxic epidermal necrolysis is the most serious form on this clinical spectrum, the hallmark of which is Nikolsky's sign (epidermal loss with lat-' eral shearing force). Again there tends to be a more serious prodromal syndrome and then a burning or painful eruption, located symmetrically on the face and upper torso.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Erythema Multiforme: Case Report and Discussion

Kroonen

1998

The Journal of the American Board of Family Medicine

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Erythema multiforme (“Minus” and “Maius”) and drug intake

Cited by 29 publications

References 105 publications

The Herpes Simplex Virus Gene Pol Expressed in Herpes-Associated Erythema Multiforme Lesions Upregulates/Activates SP1 and Inflammatory Cytokines

The Herpes Simplex Virus Gene Pol Expressed in Herpes-Associated Erythema Multiforme Lesions Upregulates/Activates SP1 and Inflammatory Cytokines

Cocaine-Related Stevens-Johnson Syndrome

Erythema Multiforme: Case Report and Discussion

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